WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598965
CAS#: 11075-87-9
Description: U-26146D is a novel antifungal antibiotic.
MedKoo Cat#: 598965
Name: U-26146D
CAS#: 11075-87-9
Chemical Formula: C38H74N4O14S
Exact Mass:
Molecular Weight: 843.08
Elemental Analysis: C, 54.14; H, 8.85; N, 6.65; O, 26.57; S, 3.80
This product is not in stock, which may be available by custom synthesis.
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Synonym: Lipoxamycin; U-26146D; U 26146D; U26146D;
IUPAC/Chemical Name: (S)-2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)propanamide hemisulfate
InChi Key: LQVOFMWEPHCSIY-IJBYHFJWSA-N
InChi Code: InChI=1S/2C19H36N2O5.H2O4S/c2*1-15(2)8-7-11-16(23)9-5-3-4-6-10-17(24)12-13-21(26)19(25)18(20)14-22;1-5(2,3)4/h2*15,18,22,26H,3-14,20H2,1-2H3;(H2,1,2,3,4)/t2*18-;/m00./s1
SMILES Code: OC[C@@H](C(N(CCC(CCCCCCC(CCCC(C)C)=O)=O)O)=O)N.OC[C@H](N)C(N(CCC(CCCCCCC(CCCC(C)C)=O)=O)O)=O.OS(O)(=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 843.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mandala SM, Frommer BR, Thornton RA, Kurtz MB, Young NM, Cabello MA, Genilloud O, Liesch JM, Smith JL, Horn WS. Inhibition of serine palmitoyl-transferase activity by lipoxamycin. J Antibiot (Tokyo). 1994 Mar;47(3):376-9. PubMed PMID: 8175492.
2: Whaley HA. The structure of lipoxamycin, a novel antifungal antibiotic. J Am Chem Soc. 1971 Jul 28;93(15):3767-9. PubMed PMID: 5091204.
3: Roy SK, Inouye Y, Nakamura S, Furukawa J, Okuda S. Isolation, structural elucidation and biological properties of neoenactins B1, B2, M1 and M2, neoenactin congeners. J Antibiot (Tokyo). 1987 Mar;40(3):266-74. PubMed PMID: 3570978.
4: Whaley HA, Sebek OK, Lewis C. Production, isolation, characterization, and evaluation of lipoxamycin, a new antifungal agent. Antimicrob Agents Chemother (Bethesda). 1970;10:455-61. PubMed PMID: 5521367.
