Bromazine HCl| CAS#1808-12-4 | Antihistaminic

Bromazine HCl
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592774

CAS#: 1808-12-4 (HCl)

Description: Bromazine (trade names Ambodryl, Ambrodil and others), also known as bromodiphenhydramine, is an antihistamine and anticholinergic. It is a brominated form of diphenhydramine.

Chemical Structure

Bromazine HCl

CAS# 1808-12-4 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 592774
Name: Bromazine HCl
CAS#: 1808-12-4 (HCl)
Chemical Formula: C17H21BrClNO
Exact Mass: 0.00
Molecular Weight: 370.715
Elemental Analysis: C, 55.08; H, 5.71; Br, 21.55; Cl, 9.56; N, 3.78; O, 4.32

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 450
200mg	USD 750
500mg	USD 1650
1g	USD 2950
2g	USD 4250
5g	USD 6950
10g	USD 8950
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 118-23-0 (free base) 1808-12-4 (HCl)

Synonym: Bromodiphenhydramine hydrochloride; Bromazine HCl; Bromazine hydrohloride

IUPAC/Chemical Name: 2-((4-Bromophenyl)phenylmethoxy)ethyl(dimethyl)ammonium chloride

InChi Key: ZQDJSWUEGOYDGT-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H

SMILES Code: C[NH+](CCOC(C1=CC=C(Br)C=C1)C2=CC=CC=C2)C.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 370.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: MACLAREN WR, BRUFF WC, EISENBERG BC, WEINER H, MARTIN WH. A clinical comparison of carbinoxamine maleate, tripelennamine hydrochloride, and bromodiphenhydramine hydrochloride in treating allergic symptoms. Ann Allergy. 1955 May-Jun;13(3):307-12. PubMed PMID: 14377226.

2: MOLINA EB. [A new antihistaminic, bromodiphenhydramine hydrochloride, in the control of cutaneous allergies]. Sem Med. 1960 Jul 11;117:151-2. Spanish. PubMed PMID: 13771809.

3: Attwood D, Udeala OK. Aggregation of antihistamines in aqueous solution. The effect of electrolyte on the miscellar properties of some diphenylmethane derivatives. J Pharm Pharmacol. 1975 Jun;27(6):395-9. PubMed PMID: 237086.

4: Ray S, Chattopadhyay D, Dastidar SG, Chakrabarty AN. Studies on synergism between penicillins and ambodryl (bromodiphenhydramine HCl), an antihistamine with antimicrobial property. Indian J Exp Biol. 1990 Mar;28(3):253-8. PubMed PMID: 1973150.

5: DE MATTEIS M, RIMOLDI R. [Clinico-statistical research on a hypnotic & sedative drug (bromodiphenhydramine ethinamate)]. Minerva Med. 1959 Mar 21;50(23):823-7. Italian. PubMed PMID: 13656702.

6: Ahmadi A, Khalili M, Nafarie A, Yazdani A, Nahri-Niknafs B. Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs. Mini Rev Med Chem. 2012 Oct;12(12):1282-92. PubMed PMID: 22876948.

7: Fusari SA, Terhalle M, Holcomb IJ, Alix EC. Reverse phase thin-layer chromatographic separation of bromodiphenhydramine and diphenhydramine. J Chromatogr Sci. 1975 Dec;13(12):563-4. PubMed PMID: 1194397.

8: Chakrabarty AN, Acharya DP, Neogi D, Dastidar SG. Drug interaction of promethazine & other non-conventional antimicrobial chemotherapeutic agents. Indian J Med Res. 1989 Jul;89:233-7. PubMed PMID: 2807428.

9: Atherton AD, Barry BW. Photon correlation spectroscopy of surface active cationic drugs. J Pharm Pharmacol. 1985 Dec;37(12):854-62. PubMed PMID: 2868091.

10: BAIRD JA, BOYD EM. Bromazine hydrochloride and complex coordinated reflex activity. J Pharm Pharmacol. 1954 Jan;6(1):38-42. PubMed PMID: 13118513.

11: THOMAS JW, KELLY FR Jr. Further notes on the clinical use of ambodryl hydrochloride. Ann Allergy. 1952 Nov-Dec;10(6):725-6. PubMed PMID: 13017403.

12: BOYD EM, HICKS RN. The failure of bromazine hydrochloride to affect the output and composition of respiratory tract fluid. J Pharm Pharmacol. 1954 Jan;6(1):43-9. PubMed PMID: 13118514.

13: THOMAS JW, KELLY FR Jr. The clinical evaluation of ambodryl hydrochloride; a report of 100 cases. Ann Allergy. 1951 Jul-Aug;9(4):481-6. PubMed PMID: 14847432.

14: DORSCH W. [Research on the effects of the new antihistaminic Ambodryl on driving fitness]. Munch Med Wochenschr. 1961 May 12;103:1014-7. German. PubMed PMID: 13723965.

15: Ray S, Dastidar SG, Chakrabarty AN. Antibiotic cross-resistance patterns of ambodryl and promazine resistant mutants. Br J Exp Pathol. 1980 Oct;61(5):465-70. PubMed PMID: 6108782; PubMed Central PMCID: PMC2041529.

16: Chattopadhyay D, Dastidar SG, Chakrabarty AN. Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents. Arzneimittelforschung. 1988 Jul;38(7):869-72. PubMed PMID: 2905130.

17: Ullrich KJ, Rumrich G, David C, Fritzsch G. Bisubstrates: substances that interact with renal contraluminal organic anion and organic cation transport systems. I. Amines, piperidines, piperazines, azepines, pyridines, quinolines, imidazoles, thiazoles, guanidines and hydrazines. Pflugers Arch. 1993 Nov;425(3-4):280-99. PubMed PMID: 8309790.

18: Parry R, Calvert RT. The disposition of diphenhydramine and four of its analogues in rabbits and implication for structure-activity relationship studies in drug design. Biopharm Drug Dispos. 1982 Jul-Sep;3(3):255-65. PubMed PMID: 7139065.

19: McGAVACK TH, WEISSBERG J, SHEARMAN AM. Newer antihistamines; effectiveness and side effects of long-continued use of ambodryl. Ann Allergy. 1952 Mar-Apr;10(2):172-8. PubMed PMID: 14915362.

20: DESHMANKER BS, AGARWAL SL. The action of three recent antihistaminic drugs--ambodryl, sandosten and synopen on bronchial muscle. Indian J Med Sci. 1959 Sep;13:762-6. PubMed PMID: 13816133.

Your view history

Bromazine HCl featured