WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 592749
CAS#: 84777-85-5
Description: Virustomycin A is a macrolide antibiotic active against infectious and plant pathogenic fungi. It decreases plaque formation by RNA and DNA viruses.
MedKoo Cat#: 592749
Name: Virustomycin A
CAS#: 84777-85-5
Chemical Formula: C48H71NO14
Exact Mass: 885.4875
Molecular Weight: 886.089
Elemental Analysis: C, 65.06; H, 8.08; N, 1.58; O, 25.28
Synonym: Virustomycin A; Antibiotic AM-2604 A
IUPAC/Chemical Name: Concanamycin A, 23-O-de(4-O-(aminocarbonyl)-2,6-dideoxy-beta-D-arabino-hexopyranosyl)-23-O-(4-((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)-1,4-dioxo-2-butenyl)-
InChi Key: YIKWIQAIKGWYCF-QTAFVZCYSA-N
InChi Code: InChI=1S/C48H71NO14/c1-12-15-36-30(7)39(61-41(53)21-20-40(52)49-42-34(50)18-19-35(42)51)25-48(58,63-36)32(9)45(56)31(8)46-37(59-10)17-14-16-26(3)22-28(5)43(54)33(13-2)44(55)29(6)23-27(4)24-38(60-11)47(57)62-46/h12,14-17,20-21,23-24,28-33,36-37,39,43-46,50,54-56,58H,13,18-19,22,25H2,1-11H3,(H,49,52)/b15-12-,17-14+,21-20+,26-16+,27-23-,38-24-/t28-,29-,30-,31+,32+,33+,36-,37+,39-,43+,44-,45-,46+,48-/m1/s1
SMILES Code: C(\C=C\C(=O)NC1=C(CCC1=O)O)(=O)O[C@@H]1C[C@](O[C@@H]([C@H]1C)\C=C/C)(O)[C@H]([C@@H]([C@H](C)[C@@H]1OC(C(=CC(=C[C@H]([C@H]([C@H]([C@H]([C@@H](CC(=CC=C[C@@H]1OC)C)C)O)CC)O)C)C)OC)=O)O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 886.089 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Otoguro K, Ishiyama A, Namatame M, Nishihara A, Furusawa T, Masuma R, Shiomi K, Takahashi Y, Yamada H, Omura S. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J Antibiot (Tokyo). 2008 Jun;61(6):372-8. doi: 10.1038/ja.2008.52. PubMed PMID: 18667785.
2: Hayakawa Y, Takaku K, Furihata K, Nagai K, Seto H. Isolation and structural elucidation of new 18-membered macrolide antibiotics, viranamycins A and B. J Antibiot (Tokyo). 1991 Dec;44(12):1294-9. PubMed PMID: 1778781.
3: Omura S, Imamura N, Hinotozawa K, Otoguro K, Lukacs G, Faghih R, Tolmann R, Arison BH, Smith JL. The structure of virustomycin A. J Antibiot (Tokyo). 1983 Dec;36(12):1783-6. PubMed PMID: 6662820.
4: Omura S, Otoguro K, Tanaka H. The mode of action of a novel 18-membered macrolide, virustomycin A (AM-2604 A), on Trichomonas foetus. J Antibiot (Tokyo). 1983 Dec;36(12):1755-61. PubMed PMID: 6662816.
5: Omura S, Shimizu H, Iwai Y, Hinotozawa K, Otoguro K, Hashimoto H, Nakagawa A. AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces. J Antibiot (Tokyo). 1982 Dec;35(12):1632-7. PubMed PMID: 7166528.
