WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555293
Description: E17110 is a LXRβ agonist. E17110 showed a significant activation effect on LXRβ with an EC50 value of 0.72 μmol/L. E17110 also increased the expression of ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 macrophages. Moreover, E17110 significantly reduced cellular lipid accumulation and promoted cholesterol efflux in RAW264.7 macrophages.
MedKoo Cat#: 555293
Chemical Formula: C16H15FN2O5
Exact Mass: 334.0965
Molecular Weight: 334.3034
Elemental Analysis: C, 57.49; H, 4.52; F, 5.68; N, 8.38; O, 23.93
This product is not in stock, which may be available by custom synthesis.
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Synonym: E17110; E-17110; E 17110.
IUPAC/Chemical Name: 1-oxo-1-(2-oxoimidazolidin-1-yl)propan-2-yl 6-fluoro-3-methylbenzofuran-2-carboxylate
InChi Key: SMRPARLQNTVFLB-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H15FN2O5/c1-8-11-4-3-10(17)7-12(11)24-13(8)15(21)23-9(2)14(20)19-6-5-18-16(19)22/h3-4,7,9H,5-6H2,1-2H3,(H,18,22)
SMILES Code: FC1=CC=C2C(OC(C(OC(C(N3C(NCC3)=O)=O)C)=O)=C2C)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 334.3034 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Li N, Wang X, Liu P, Lu D, Jiang W, Xu Y, Si S. E17110 promotes reverse
cholesterol transport with liver X receptor β agonist activity in vitro. Acta
Pharm Sin B. 2016 May;6(3):198-204. doi: 10.1016/j.apsb.2016.03.005. Epub 2016
Apr 5. PubMed PMID: 27175330; PubMed Central PMCID: PMC4856951.
2: Pandit B, Gartel AL. Thiazole antibiotic thiostrepton synergize with
bortezomib to induce apoptosis in cancer cells. PLoS One. 2011 Feb
18;6(2):e17110. doi: 10.1371/journal.pone.0017110. PubMed PMID: 21365012; PubMed
Central PMCID: PMC3041825.