Quinacainol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461451

CAS#: 86073-85-0

Description: Quinacainol is a Class I antiarrhythmic drug.


Chemical Structure

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Quinacainol
CAS# 86073-85-0

Theoretical Analysis

MedKoo Cat#: 461451
Name: Quinacainol
CAS#: 86073-85-0
Chemical Formula: C21H30N2O
Exact Mass: 326.24
Molecular Weight: 326.480
Elemental Analysis: C, 77.26; H, 9.26; N, 8.58; O, 4.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Quinacainol; PK 10139; PK-10139; PK10139; RP 54272; RP-54272; RP54272;

IUPAC/Chemical Name: 1-(2-(tert-butyl)quinolin-4-yl)-3-(piperidin-4-yl)propan-1-ol

InChi Key: OPNPUTUBENWDBA-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H30N2O/c1-21(2,3)20-14-17(16-6-4-5-7-18(16)23-20)19(24)9-8-15-10-12-22-13-11-15/h4-7,14-15,19,22,24H,8-13H2,1-3H3

SMILES Code: OC(CCC1CCNCC1)C2=CC(C(C)(C)C)=NC3=CC=CC=C23

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 326.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Pugsley MK, Walker MJ, Saint DA. Block of NA+ and K+ currents in rat ventricular myocytes by quinacainol and quinidine. Clin Exp Pharmacol Physiol. 2005 Jan-Feb;32(1-2):60-5. PubMed PMID: 15730436.

2: Howard PG, MacLeod BA, Walker MJ. Quinacainol, a new antiarrhythmic with class I antiarrhythmic actions in the rat. Eur J Pharmacol. 1992 Aug 14;219(1):1-8. PubMed PMID: 1397036.

3: Penz W, Pugsley M, Hsieh MZ, Walker MJ. A new ECG measure (RSh) for detecting possible sodium channel blockade in vivo in rats. J Pharmacol Toxicol Methods. 1992 Mar;27(1):51-8. PubMed PMID: 1316193.

4: Drobinski G, Montalescot G, Krumenacker M, Moussallem N, Grosgogeat Y. Haemodynamic effects of intravenous quinacainol with and without autonomic nervous system blockade. Int J Cardiol. 1991 Mar;30(3):341-7. PubMed PMID: 1676019.

5: Drobinski G, Montalescot G, Moussallem N, Krumenacker M, Grosgogeat Y. [Hemodynamic effects of quinacainol administered via an intravenous route. Study in patients with normal left ventricular function]. Therapie. 1990 Mar-Apr;45(2):119-23. French. PubMed PMID: 2191468.

6: Howard PG, Walker MJ. Electrical stimulation studies with quinacainol, a putative 1C agent, in the anaesthetised rat. Proc West Pharmacol Soc. 1990;33:123-7. PubMed PMID: 2274522.

7: Jaillon P, Drici M. Recent antiarrhythmic drugs. Am J Cardiol. 1989 Dec 5;64(20):65J-69J. Review. PubMed PMID: 2688391.

8: Voigt W, Mannhold R, Limberg J, Blaschke G. Interactions of antiarrhythmics with artificial phospholipid membranes. J Pharm Sci. 1988 Dec;77(12):1018-20. PubMed PMID: 3244104.