WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461450
CAS#: 3639-19-8
Description: Difetarsone is an antiprotozoal agent. Various studies have shown it to be particularly effective against Trichuris trichiura, commonly known as the whipworm. It has also been used to treat Entamoeba histolytica infections. Prior to the drugs use in the early 1970s, there were few effective treatments for this infection. Difetarsone often has minor side effects, which include rashes, nausea and vomiting. It has also resulted in angioedema in at least one known case.
MedKoo Cat#: 461450
Name: Difetarsone
CAS#: 3639-19-8
Chemical Formula: C14H18As2N2O6
Exact Mass: 459.9597
Molecular Weight: 460.14
Elemental Analysis: C, 36.54; H, 3.94; As, 32.56; N, 6.09; O, 20.86
Synonym: Difetarsone; Difetarsonum; Diphetarson; RP 4763; RP-4763; RP4763; Benarsal;
IUPAC/Chemical Name: ((ethane-1,2-diylbis(azanediyl))bis(4,1-phenylene))diarsonic acid
InChi Key: YQVALJGIKVYRNI-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H18As2N2O6/c19-15(20,21)11-1-5-13(6-2-11)17-9-10-18-14-7-3-12(4-8-14)16(22,23)24/h1-8,17-18H,9-10H2,(H2,19,20,21)(H2,22,23,24)
SMILES Code: O=[As](C1=CC=C(NCCNC2=CC=C([As](O)(O)=O)C=C2)C=C1)(O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
| Biological target: | Difetarsone is an antiprotozoal agent. |
| In vitro activity: | TBD |
| In vivo activity: | TBD |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 0.0 | 0.0 |
The following data is based on the product molecular weight 460.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | TBD |
| In vitro protocol: | TBD |
| In vivo protocol: | TBD |
1: Vandepitte J, Thienpont D. Trichuris infestations and difetarsone. Br Med J. 1972 Dec 2;4(5839):549. PubMed PMID: 4642803; PubMed Central PMCID: PMC1788733.
2: Leary PM, Jones C, Douglas F, Boyd ST. Difetarsone in outpatient treatment of Trichuris trichiura infestation. Arch Dis Child. 1974 Jun;49(6):486-8. PubMed PMID: 4851370; PubMed Central PMCID: PMC1648795.
3: Leary PM, Elsworth M, Maytham D, Jones C, Douglas F, Boyd S. Difetarsone in the treatment of Trichuris trichiura. S Afr Med J. 1973 Aug 11;47(31):1389. PubMed PMID: 4578732.
4: Boyce JM, Fitzgerald TC, Gregg R. Difetarsone ('Bemarsal') and other anthelminthic drugs in the treatment of Trichuris trichiura (whipworm) infestation in a subnormality hospital. Br J Psychiatry. 1974 Feb;124(579):160-5. PubMed PMID: 4825661.
5: Vandepitte J, Gatti F, Krubwa F, Thienpont D. Letter: Difetarsone in the treatment of Trichuris trichiura. S Afr Med J. 1973 Nov 24;47(46):2205. PubMed PMID: 4760912.
6: Rubidge CJ, O'Dowd PB, Powell SJ. Difetarsone in the treatment of Trichuris trichiura infections. S Afr Med J. 1973 Jun 16;47(23):991-2. PubMed PMID: 4714286.
7: Lynch DM, Green EA, McFadzean JA, Pugh IM. Trichuris trichiura infestations in the United Kingdom and treatment with difetarsone. Br Med J. 1972 Oct 14;4(5832):73-6. PubMed PMID: 5077469; PubMed Central PMCID: PMC1786249.
8: Vetter D, Arpin MP, Doffoël M, Charrault A, Biour M, Bockel R. [Prolonged hepatitis after ingestion of diphetarsone]. Gastroenterol Clin Biol. 1988 Feb;12(2):173-4. French. PubMed PMID: 3366319.
9: Labadie H, Dyan S, Novello P, Pouteau M, Licht H. [Diphetarsone-induced hepatitis. A second case]. Presse Med. 1992 Jun 6;21(21):996. French. PubMed PMID: 1386461.
