WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 592687
CAS#: 528-71-2
Description: Hemipyocyanine is the virulence factor of Pseudomonas aeruginosa.
MedKoo Cat#: 592687
Name: Hemipyocyanine
CAS#: 528-71-2
Chemical Formula: C12H8N2O
Exact Mass: 196.0637
Molecular Weight: 196.209
Elemental Analysis: C, 73.46; H, 4.11; N, 14.28; O, 8.15
Synonym: Hemipyocyanine, NSC 88882
IUPAC/Chemical Name: 1-Phenazinol
InChi Key: SVRNCBGWUMMBQB-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H8N2O/c15-11-7-3-6-10-12(11)14-9-5-2-1-4-8(9)13-10/h1-7,15H
SMILES Code: OC1=CC=CC2=NC3=CC=CC=C3N=C21
Appearance: A crystalline solid
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 196.209 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Ramafi, G., Anderson, R., Theron, A., et al. Exposure of N-formyl-L-methionyl-L-leucyl-L-phenylalanine-activated human neutrophils to the Pseudomonas aeruginosa-derived pigment 1-hydroxyphenazine is associated with impaired calcium efflux and potentiation of primary granule enzyme release. Infect. Immun. 67(10), 5157-5162 (1999).
2. Sinha, S., Shen, X., Gallazzi, F., et al. Generation of reactive oxygen species mediated by 1‑hydroxyphenazine, a virulence factor of Pseudomonas aeruginosa. Chem. Res. Toxicol. 28(2), 175-181 (2015).
3. Munro, N.C., Barker, A., Rutman, A., et al. Effect of pyocyanin and 1-hydroxyphenazine on in vivo tracheal mucus velocity. J. Appl. Physiol. 67(1), 316-323 (1985).
4. Luo, Q., Hu, H., Peng, H., et al. Isolation and structural identification of two bioactive phenazines from Streptomyces griseoluteus P510. Chin. J. Chem. Eng. 23(4), 699-703 (2015).
