Benactyzine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592680

CAS#: 302-40-9

Description: Benactyzine is a centrally acting muscarinic antagonist.


Chemical Structure

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Benactyzine
CAS# 302-40-9

Theoretical Analysis

MedKoo Cat#: 592680
Name: Benactyzine
CAS#: 302-40-9
Chemical Formula: C20H25NO3
Exact Mass: 327.18
Molecular Weight: 327.420
Elemental Analysis: C, 73.37; H, 7.70; N, 4.28; O, 14.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Benactyzine

IUPAC/Chemical Name: 2-Diethylaminoethyl benzilate

InChi Key: IVQOFBKHQCTVQV-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3

SMILES Code: OC(C1=CC=CC=C1)(C2=CC=CC=C2)C(OCCN(CC)CC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 327.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Petkov V, Donev N, Todorov S. Effect of acute radiation sickness on the reactivity of guinea-pig colon and rabbit duodenum to acetylcholine, histamine and serotonin, and to their combinations with benactyzine and pyrimetine. Acta Physiol Pharmacol Bulg. 1978;4(3):21-8. PubMed PMID: 751448.

2: NATHAN PW. Benactyzine in patients with violent tempers and patients with Parkinsonism. Br Med J. 1958 Apr 19;1(5076):926-8. PubMed PMID: 13523231; PubMed Central PMCID: PMC2028375.

3: BATEMAN JC, CARLTON HM. Meprobamate and benactyzine hydrochloride (deprol) as adjunctive therapy for patients with advanced cancer. Antibiotic Med Clin Ther (New York). 1959 Nov;6:648-52. PubMed PMID: 13797484.

4: Montoliu García A, Escudero JJ, Fabuel Deltoro M, Serrano de la Cruz Torrijos F, Alvarez Barrera A, Amorós Torres A, Ramos de Campos M, Marqués Vidal E. [Tolerance of prostate biopsy with use of local anesthesia and benzodiazepines: a randomized, prospective study]. Actas Urol Esp. 2010 Jan;34(1):43-50. Spanish. PubMed PMID: 20223132.

5: Vovin RIa, Fakturovich AIa, Golenkov AV, Lukin VO. [Correction of apathetic-abulic manifestations of schizophrenia with cholinotropic drugs]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(2):111-5. Russian. PubMed PMID: 1647606.

6: Richter W. Estimation of anticholinergic drug effects in mice by antagonism against pilocarpine-induced salivation. Acta Pharmacol Toxicol (Copenh). 1966;24(2):243-54. PubMed PMID: 6013093.

7: Anisimov VN. Pharmacological study of cholinergic mechanisms of compensatory ovarian hypertrophy in rats. Endokrinologie. 1978 Apr;71(2):149-53. PubMed PMID: 27348.

8: Nezhentsev MV, Aleksandrov SI. [Evaluation of the antipyretic action of psychotropic drugs and their effect on the antipyretic effect of acupuncture therapy]. Biull Eksp Biol Med. 1993 Mar;115(3):262-4. Russian. PubMed PMID: 8054614.

9: Chesnokova NP. [Role of disorders in biogenic amine metabolism in the pathogenesis of botulin poisoning]. Vopr Med Khim. 1977 Mar-Apr;23(2):261-6. Russian. PubMed PMID: 883162.

10: Witkin JM, Gordon RK, Chiang PK. Comparison of in vitro actions with behavioral effects of antimuscarinic agents. J Pharmacol Exp Ther. 1987 Sep;242(3):796-803. PubMed PMID: 3498817.

11: Deprol advertising. Med Lett Drugs Ther. 1967 Feb 24;9(4):13-5. PubMed PMID: 6045226.

12: HUKUHARA T. [The effect of tranquilizers on the electrical activity of cortical and subcortical structures in the cat]. Arzneimittelforschung. 1962 Dec;12:1133-43. German. PubMed PMID: 13955625.

13: Nikitina GV. [Various findings on the mechanism of action of the contraceptive drug megestranol]. Akush Ginekol (Mosk). 1971 Feb;47(2):22-4. Russian. PubMed PMID: 4399100.

14: MCCANCE I. STUDIES OF POTENTIATION OF HEXOBARBITONE INFUSED INTRAVENOUSLY. Arch Int Pharmacodyn Ther. 1964 Mar 1;148:270-86. PubMed PMID: 14171755.

15: Shvyrkova NA. [Changes in the impulse activity of cortical neurons during pharmacological blockade of ascending activating influences]. Dokl Akad Nauk SSSR. 1970;192(5):1178-80. Russian. PubMed PMID: 4319615.

16: Koluch J, Tabarka K. [Effect of various psychopharmacological agents on ultraviolet erythemic reaction]. Fysiatr Revmatol Vestn. 1969 Feb;47(1):43-6. Czech. PubMed PMID: 5816163.

17: Kanzawa F, Hoshi A, Kuretani K. Relationship between antitumor activity and chemical structure in psychotropic agents. Gan. 1970 Dec;61(6):529-34. PubMed PMID: 5499680.

18: BERMUDEZ DN, MEIER GN, BRIEVA AJ. [APPLICATION OF THE CHEMICAL METHODS OF EVALUATION OF MEPROBAMATE TO ITS ASSOCIATED COMPOUNDS]. An Real Acad Farm. 1963;29:35-49. Spanish. PubMed PMID: 14106727.

19: Poskalenko AN, Savchenko ON, Nikitina GV, Sokolov EG. [Change in the gonadotropic function in rats during the use of the new Soviet contraceptive megestranol]. Probl Endokrinol (Mosk). 1973 Mar-Apr;19(2):87-93. Russian. PubMed PMID: 4145396.

20: RYZHENKOV VE, PAVLYSH VV. [INHIBITING ACTION OF METAMIZIL ON THE GONADOTROPIC FUNCTION OF THE PITUITARY GLAND]. Probl Endokrinol Gormonoter. 1964 May-Jun;10:102-4. Russian. PubMed PMID: 14210096.