Benactyzine

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MedKoo CAT#: 592680

CAS#: 302-40-9

Description: Benactyzine is a centrally acting muscarinic antagonist.


Price and Availability

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Pricing updated 2020-08-10. Prices are subject to change without notice.

Benactyzine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 592680
Name: Benactyzine
CAS#: 302-40-9
Chemical Formula: C20H25NO3
Exact Mass: 327.1834
Molecular Weight: 327.42
Elemental Analysis: C, 73.37; H, 7.70; N, 4.28; O, 14.66


Synonym: Benactyzine

IUPAC/Chemical Name: 2-Diethylaminoethyl benzilate

InChi Key: IVQOFBKHQCTVQV-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H25NO3/c1-3-21(4-2)15-16-24-19(22)20(23,17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,23H,3-4,15-16H2,1-2H3

SMILES Code: OC(C1=CC=CC=C1)(C2=CC=CC=C2)C(OCCN(CC)CC)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Petkov V, Donev N, Todorov S. Effect of acute radiation sickness on the reactivity of guinea-pig colon and rabbit duodenum to acetylcholine, histamine and serotonin, and to their combinations with benactyzine and pyrimetine. Acta Physiol Pharmacol Bulg. 1978;4(3):21-8. PubMed PMID: 751448.

2: NATHAN PW. Benactyzine in patients with violent tempers and patients with Parkinsonism. Br Med J. 1958 Apr 19;1(5076):926-8. PubMed PMID: 13523231; PubMed Central PMCID: PMC2028375.

3: BATEMAN JC, CARLTON HM. Meprobamate and benactyzine hydrochloride (deprol) as adjunctive therapy for patients with advanced cancer. Antibiotic Med Clin Ther (New York). 1959 Nov;6:648-52. PubMed PMID: 13797484.

4: Montoliu García A, Escudero JJ, Fabuel Deltoro M, Serrano de la Cruz Torrijos F, Alvarez Barrera A, Amorós Torres A, Ramos de Campos M, Marqués Vidal E. [Tolerance of prostate biopsy with use of local anesthesia and benzodiazepines: a randomized, prospective study]. Actas Urol Esp. 2010 Jan;34(1):43-50. Spanish. PubMed PMID: 20223132.

5: Vovin RIa, Fakturovich AIa, Golenkov AV, Lukin VO. [Correction of apathetic-abulic manifestations of schizophrenia with cholinotropic drugs]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(2):111-5. Russian. PubMed PMID: 1647606.

6: Richter W. Estimation of anticholinergic drug effects in mice by antagonism against pilocarpine-induced salivation. Acta Pharmacol Toxicol (Copenh). 1966;24(2):243-54. PubMed PMID: 6013093.

7: Anisimov VN. Pharmacological study of cholinergic mechanisms of compensatory ovarian hypertrophy in rats. Endokrinologie. 1978 Apr;71(2):149-53. PubMed PMID: 27348.

8: Nezhentsev MV, Aleksandrov SI. [Evaluation of the antipyretic action of psychotropic drugs and their effect on the antipyretic effect of acupuncture therapy]. Biull Eksp Biol Med. 1993 Mar;115(3):262-4. Russian. PubMed PMID: 8054614.

9: Chesnokova NP. [Role of disorders in biogenic amine metabolism in the pathogenesis of botulin poisoning]. Vopr Med Khim. 1977 Mar-Apr;23(2):261-6. Russian. PubMed PMID: 883162.

10: Witkin JM, Gordon RK, Chiang PK. Comparison of in vitro actions with behavioral effects of antimuscarinic agents. J Pharmacol Exp Ther. 1987 Sep;242(3):796-803. PubMed PMID: 3498817.

11: Deprol advertising. Med Lett Drugs Ther. 1967 Feb 24;9(4):13-5. PubMed PMID: 6045226.

12: HUKUHARA T. [The effect of tranquilizers on the electrical activity of cortical and subcortical structures in the cat]. Arzneimittelforschung. 1962 Dec;12:1133-43. German. PubMed PMID: 13955625.

13: Nikitina GV. [Various findings on the mechanism of action of the contraceptive drug megestranol]. Akush Ginekol (Mosk). 1971 Feb;47(2):22-4. Russian. PubMed PMID: 4399100.

14: MCCANCE I. STUDIES OF POTENTIATION OF HEXOBARBITONE INFUSED INTRAVENOUSLY. Arch Int Pharmacodyn Ther. 1964 Mar 1;148:270-86. PubMed PMID: 14171755.

15: Shvyrkova NA. [Changes in the impulse activity of cortical neurons during pharmacological blockade of ascending activating influences]. Dokl Akad Nauk SSSR. 1970;192(5):1178-80. Russian. PubMed PMID: 4319615.

16: Koluch J, Tabarka K. [Effect of various psychopharmacological agents on ultraviolet erythemic reaction]. Fysiatr Revmatol Vestn. 1969 Feb;47(1):43-6. Czech. PubMed PMID: 5816163.

17: Kanzawa F, Hoshi A, Kuretani K. Relationship between antitumor activity and chemical structure in psychotropic agents. Gan. 1970 Dec;61(6):529-34. PubMed PMID: 5499680.

18: BERMUDEZ DN, MEIER GN, BRIEVA AJ. [APPLICATION OF THE CHEMICAL METHODS OF EVALUATION OF MEPROBAMATE TO ITS ASSOCIATED COMPOUNDS]. An Real Acad Farm. 1963;29:35-49. Spanish. PubMed PMID: 14106727.

19: Poskalenko AN, Savchenko ON, Nikitina GV, Sokolov EG. [Change in the gonadotropic function in rats during the use of the new Soviet contraceptive megestranol]. Probl Endokrinol (Mosk). 1973 Mar-Apr;19(2):87-93. Russian. PubMed PMID: 4145396.

20: RYZHENKOV VE, PAVLYSH VV. [INHIBITING ACTION OF METAMIZIL ON THE GONADOTROPIC FUNCTION OF THE PITUITARY GLAND]. Probl Endokrinol Gormonoter. 1964 May-Jun;10:102-4. Russian. PubMed PMID: 14210096.