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MedKoo CAT#: 598693

CAS#: 23360-92-1

Description: Vinleurosine is an alkaloid originally found in species of Catharanthus that, like other similar alkaloids, may exhibit anticancer chemotherapeutic activity.

Price and Availability

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Pricing updated 2020-07-14. Prices are subject to change without notice.

Vinleurosine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 598693
Name: Vinleurosine
CAS#: 23360-92-1
Chemical Formula: C46H56N4O9
Exact Mass: 808.4047
Molecular Weight: 808.97
Elemental Analysis: C, 68.30; H, 6.98; N, 6.93; O, 17.80

Synonym: Vinleurosine; NSC 528004; NSC-528004; NSC528004; Amotin; Leurosine;

IUPAC/Chemical Name: methyl (1aS,3R,11S,13S,13aR)-11-((3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-5-hydroxy-8-methoxy-5-(methoxycarbonyl)-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl)-1a-ethyl-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methanooxireno[2',3':9,10][1]azacycloundecino[5,4-b]indole-11-carboxylate


InChi Code: 1S/C46H56N4O9/c1-8-42-16-12-18-50-20-17-44(37(42)50)30-21-31(34(55-5)22-33(30)48(4)38(44)46(54,41(53)57-7)39(42)58-26(3)51)45(40(52)56-6)23-27-24-49(25-43(9-2)36(27)59-43)19-15-29-28-13-10-11-14-32(28)47-35(29)45/h10-14,16,21-22,27,36-39,47,54H,8-9,15,17-20,23-25H2,1-7H3/t27-,36+,37-,38+,39+,42+,43-,44+,45-,46-/m0/s1

SMILES Code: CC[C@]12C[N@@]3CCc4c([C@](c5c(OC)cc(N(C)[C@@H]6[C@]78CCN9[C@H]8[C@@]([C@@H](OC(C)=O)[C@]6(O)C(OC)=O)(CC)C=CC9)c7c5)(C(OC)=O)C[C@H]([C@H]1O2)C3)[nH]c%10c4cccc%10

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Chen Q, Zhang W, Zhang Y, Chen J, Chen Z. Identification and quantification of active alkaloids in Catharanthus roseus by liquid chromatography-ion trap mass spectrometry. Food Chem. 2013 Aug 15;139(1-4):845-52. doi: 10.1016/j.foodchem.2013.01.088. Epub 2013 Feb 9. PubMed PMID: 23561180.

2: Creasey WA. Biochemical effects of the Vinca alkaloids. IV. Studies with vinleurosine. Biochem Pharmacol. 1969 Jan;18(1):227-32. PubMed PMID: 5780988.

3: Gailani SD, Armstrong JG, Carbone PP, Tan C, Holland JF. Clinical trial of vinleurosine sulfate (NSC-90636): a new drug derived from Vinca rosea Linn. Cancer Chemother Rep. 1966 Jan-Feb;50(1):95-103. PubMed PMID: 5908742.

4: Zhang L, Gai QH, Zu YG, Yang L, Ma YL, Liu Y. Simultaneous quantitative determination of five alkaloids in Catharanthus roseus by HPLC-ESI-MS/MS. Chin J Nat Med. 2014 Oct;12(10):786-93. doi: 10.1016/S1875-5364(14)60120-5. Epub 2014 Oct 31. PubMed PMID: 25443373.

5: Fyfe MJ, Loftfield S, Goldman ID. A reduction in energy-dependent amino acid transport by microtubular inhibitors in Ehrlich ascites tumor cells. J Cell Physiol. 1975 Oct;86(2 Pt 1):201-11. PubMed PMID: 1194361.