Vinleurosine

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598693

CAS#: 23360-92-1

Description: Vinleurosine is an alkaloid originally found in species of Catharanthus that, like other similar alkaloids, may exhibit anticancer chemotherapeutic activity.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-14. Prices are subject to change without notice.

Vinleurosine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 598693
Name: Vinleurosine
CAS#: 23360-92-1
Chemical Formula: C46H56N4O9
Exact Mass: 808.4047
Molecular Weight: 808.97
Elemental Analysis: C, 68.30; H, 6.98; N, 6.93; O, 17.80


Synonym: Vinleurosine; NSC 528004; NSC-528004; NSC528004; Amotin; Leurosine;

IUPAC/Chemical Name: methyl (1aS,3R,11S,13S,13aR)-11-((3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-5-hydroxy-8-methoxy-5-(methoxycarbonyl)-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl)-1a-ethyl-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methanooxireno[2',3':9,10][1]azacycloundecino[5,4-b]indole-11-carboxylate

InChi Key: LPGWZGMPDKDHEP-NVDFJPPOSA-N

InChi Code: 1S/C46H56N4O9/c1-8-42-16-12-18-50-20-17-44(37(42)50)30-21-31(34(55-5)22-33(30)48(4)38(44)46(54,41(53)57-7)39(42)58-26(3)51)45(40(52)56-6)23-27-24-49(25-43(9-2)36(27)59-43)19-15-29-28-13-10-11-14-32(28)47-35(29)45/h10-14,16,21-22,27,36-39,47,54H,8-9,15,17-20,23-25H2,1-7H3/t27-,36+,37-,38+,39+,42+,43-,44+,45-,46-/m0/s1

SMILES Code: CC[C@]12C[N@@]3CCc4c([C@](c5c(OC)cc(N(C)[C@@H]6[C@]78CCN9[C@H]8[C@@]([C@@H](OC(C)=O)[C@]6(O)C(OC)=O)(CC)C=CC9)c7c5)(C(OC)=O)C[C@H]([C@H]1O2)C3)[nH]c%10c4cccc%10


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Chen Q, Zhang W, Zhang Y, Chen J, Chen Z. Identification and quantification of active alkaloids in Catharanthus roseus by liquid chromatography-ion trap mass spectrometry. Food Chem. 2013 Aug 15;139(1-4):845-52. doi: 10.1016/j.foodchem.2013.01.088. Epub 2013 Feb 9. PubMed PMID: 23561180.

2: Creasey WA. Biochemical effects of the Vinca alkaloids. IV. Studies with vinleurosine. Biochem Pharmacol. 1969 Jan;18(1):227-32. PubMed PMID: 5780988.

3: Gailani SD, Armstrong JG, Carbone PP, Tan C, Holland JF. Clinical trial of vinleurosine sulfate (NSC-90636): a new drug derived from Vinca rosea Linn. Cancer Chemother Rep. 1966 Jan-Feb;50(1):95-103. PubMed PMID: 5908742.

4: Zhang L, Gai QH, Zu YG, Yang L, Ma YL, Liu Y. Simultaneous quantitative determination of five alkaloids in Catharanthus roseus by HPLC-ESI-MS/MS. Chin J Nat Med. 2014 Oct;12(10):786-93. doi: 10.1016/S1875-5364(14)60120-5. Epub 2014 Oct 31. PubMed PMID: 25443373.

5: Fyfe MJ, Loftfield S, Goldman ID. A reduction in energy-dependent amino acid transport by microtubular inhibitors in Ehrlich ascites tumor cells. J Cell Physiol. 1975 Oct;86(2 Pt 1):201-11. PubMed PMID: 1194361.