WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563491
CAS#: 351520-91-7
Description: 2002-H20 is an inhibitior of Aβ42-induced cytotoxicity. It acts by binding the Alzheimer's Aβ peptide and reducing its cytotoxicity.
MedKoo Cat#: 563491
Name: 2002-H20
CAS#: 351520-91-7
Chemical Formula: C20H15N3O3
Exact Mass: 345.1113
Molecular Weight: 345.35
Elemental Analysis: C, 69.56; H, 4.38; N, 12.17; O, 13.90
Synonym: 2002-H20; 2002 H20; 2002H20;
IUPAC/Chemical Name: 4-amino-N-(3-(benzo[d]oxazol-2-yl)-4-hydroxyphenyl)benzamide
InChi Key: NVVIQGMTHCUMFT-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H15N3O3/c21-13-7-5-12(6-8-13)19(25)22-14-9-10-17(24)15(11-14)20-23-16-3-1-2-4-18(16)26-20/h1-11,24H,21H2,(H,22,25)
SMILES Code: O=C(NC1=CC=C(O)C(C2=NC3=CC=CC=C3O2)=C1)C4=CC=C(N)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 345.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Chebaro Y, Jiang P, Zang T, Mu Y, Nguyen PH, Mousseau N, Derreumaux P. Structures of Aβ17-42 trimers in isolation and with five small-molecule drugs using a hierarchical computational procedure. J Phys Chem B. 2012 Jul 26;116(29):8412-22. doi: 10.1021/jp2118778. Epub 2012 Feb 10. PubMed PMID: 22283547.
