Galactose
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592646

CAS#: 3646-73-9

Description: Galactose prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin.


Price and Availability

Size
Price

200mg
USD 1500
Size
Price

Size
Price

Galactose purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

No image available

Theoretical Analysis

MedKoo Cat#: 592646
Name: Galactose
CAS#: 3646-73-9
Chemical Formula: C6H12O6
Exact Mass: 180.0634
Molecular Weight: 180.16
Elemental Analysis: C, 40.00; H, 6.71; O, 53.28


Synonym: alpha-D-Galactose; Galactose

IUPAC/Chemical Name: Systematic Name alpha-D-Galactopyranose

InChi Key: WQZGKKKJIJFFOK-PHYPRBDBSA-N

InChi Code: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6+/m1/s1

SMILES Code: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Coelho AI, Berry GT, Rubio-Gozalbo ME. Galactose metabolism and health. Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):422-7. doi: 10.1097/MCO.0000000000000189. Review. PubMed PMID: 26001656.

2: Schadewaldt P, Kamalanathan L, Hammen HW, Kotzka J, Wendel U. Endogenous galactose formation in galactose-1-phosphate uridyltransferase deficiency. Arch Physiol Biochem. 2014 Dec;120(5):228-39. doi: 10.3109/13813455.2014.962547. Epub 2014 Sep 30. PubMed PMID: 25268296.

3: Salkovic-Petrisic M, Osmanovic-Barilar J, Knezovic A, Hoyer S, Mosetter K, Reutter W. Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin. Neuropharmacology. 2014 Feb;77:68-80. doi: 10.1016/j.neuropharm.2013.09.002. Epub 2013 Sep 18. PubMed PMID: 24055495.

4: Hobbs ME, Williams HJ, Hillerich B, Almo SC, Raushel FM. l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota. Biochemistry. 2014 Jul 22;53(28):4661-70. doi: 10.1021/bi500656m. Epub 2014 Jul 7. PubMed PMID: 24963813; PubMed Central PMCID: PMC4108180.

5: Kamthan M, Kamthan A, Ruhela D, Maiti P, Bhavesh NS, Datta A. Upregulation of galactose metabolic pathway by N-acetylglucosamine induced endogenous synthesis of galactose in Candida albicans. Fungal Genet Biol. 2013 May;54:15-24. doi: 10.1016/j.fgb.2013.02.006. Epub 2013 Feb 27. PubMed PMID: 23454545.

6: Bisha I, Rodriguez A, Laio A, Magistrato A. Metadynamics simulations reveal a Na+ independent exiting path of galactose for the inward-facing conformation of vSGLT. PLoS Comput Biol. 2014 Dec 18;10(12):e1004017. doi: 10.1371/journal.pcbi.1004017. eCollection 2014 Dec. PubMed PMID: 25522004; PubMed Central PMCID: PMC4270436.

7: Wang R, Wu XZ. Roles of galactose 3'-O- sulfation in signaling. Glycoconj J. 2014 Nov;31(8):549-54. doi: 10.1007/s10719-014-9558-2. Epub 2014 Oct 8. Review. PubMed PMID: 25294496.

8: Asano M. [Galactose-containing carbohydrates in the inflammation, development and nervous system]. Seikagaku. 2014 Jun;86(3):382-90. Review. Japanese. PubMed PMID: 25073377.

9: Nagy T, Frank D, Kátai E, Yahiro RK, Poór VS, Montskó G, Zrínyi Z, Kovács GL, Miseta A. Lithium induces ER stress and N-glycan modification in galactose-grown Jurkat cells. PLoS One. 2013 Jul 22;8(7):e70410. doi: 10.1371/journal.pone.0070410. Print 2013. PubMed PMID: 23894652; PubMed Central PMCID: PMC3718757.

10: Sakamoto Y, Ohta T, Ito Y. Stereoselective synthesis of UDP-2-(2-ketopropyl)galactose aided by di-tert-butylsilylene protecting group. Glycoconj J. 2015 Oct;32(7):541-8. doi: 10.1007/s10719-015-9581-y. Epub 2015 Mar 24. PubMed PMID: 25800650.

11: Phongsisay V, Iizasa E, Hara H, Yamasaki S. 3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5. Mol Immunol. 2015 Feb;63(2):595-9. doi: 10.1016/j.molimm.2014.07.023. Epub 2014 Aug 27. PubMed PMID: 25172093.

12: Mullins RJ, James H, Platts-Mills TA, Commins S. Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose. J Allergy Clin Immunol. 2012 May;129(5):1334-1342.e1. doi: 10.1016/j.jaci.2012.02.038. Epub 2012 Apr 3. PubMed PMID: 22480538; PubMed Central PMCID: PMC3340561.

13: Wang HW, Jiang PL, Lin SF, Lin HJ, Ou KL, Deng WP, Lee LW, Huang YY, Liang PH, Liu DZ. Application of galactose-modified liposomes as a potent antigen presenting cell targeted carrier for intranasal immunization. Acta Biomater. 2013 Mar;9(3):5681-8. doi: 10.1016/j.actbio.2012.11.007. Epub 2012 Nov 14. PubMed PMID: 23159567.

14: Yun EJ, Lee S, Kim JH, Kim BB, Kim HT, Lee SH, Pelton JG, Kang NJ, Choi IG, Kim KH. Enzymatic production of 3,6-anhydro-L-galactose from agarose and its purification and in vitro skin whitening and anti-inflammatory activities. Appl Microbiol Biotechnol. 2013 Apr;97(7):2961-70. doi: 10.1007/s00253-012-4184-z. Epub 2012 Jun 8. PubMed PMID: 22678025.

15: Dalkıran B, Erden PE, Kılıç E. Electrochemical biosensing of galactose based on carbon materials: graphene versus multi-walled carbon nanotubes. Anal Bioanal Chem. 2016 Jun;408(16):4329-39. doi: 10.1007/s00216-016-9532-x. Epub 2016 Apr 13. PubMed PMID: 27074783.

16: Ficicioglu C, Hussa C, Gallagher PR, Thomas N, Yager C. Monitoring of biochemical status in children with Duarte galactosemia: utility of galactose, galactitol, galactonate, and galactose 1-phosphate. Clin Chem. 2010 Jul;56(7):1177-82. doi: 10.1373/clinchem.2010.144097. Epub 2010 May 20. PubMed PMID: 20489133.

17: Fukasawa T, Abe A, Nakamura A, Horigome M, Naito A. Solid-state NMR spectroscopy reveals anomer specific transport of galactose in the milk yeast Kluyveromyces lactis. FEMS Yeast Res. 2012 Jun;12(4):415-22. doi: 10.1111/j.1567-1364.2012.00788.x. Epub 2012 Feb 13. PubMed PMID: 22239854.

18: Ioannou A, Cini E, Timofte RS, Flitsch SL, Turner NJ, Linclau B. Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase. Chem Commun (Camb). 2011 Oct 28;47(40):11228-30. doi: 10.1039/c1cc13956h. Epub 2011 Sep 13. PubMed PMID: 21915393.

19: Godoy AS, Camilo CM, Kadowaki MA, Muniz HD, Espirito Santo M, Murakami MT, Nascimento AS, Polikarpov I. Crystal structure of β1→6-galactosidase from Bifidobacterium bifidum S17: trimeric architecture, molecular determinants of the enzymatic activity and its inhibition by α-galactose. FEBS J. 2016 Nov;283(22):4097-4112. doi: 10.1111/febs.13908. Epub 2016 Oct 18. PubMed PMID: 27685756.

20: Liu N, Yang M, Mao X, Mu B, Wei D. Molecular cloning and expression of a new α-neoagarobiose hydrolase from Agarivorans gilvus WH0801 and enzymatic production of 3,6-anhydro-l-galactose. Biotechnol Appl Biochem. 2016 Mar-Apr;63(2):230-7. doi: 10.1002/bab.1363. Epub 2015 May 24. PubMed PMID: 25676340. H