AC-93253 iodide

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MedKoo CAT#: 563464

CAS#: 108527-83-9 (iodide)

Description: AC-93253 iodide is a SIRT2 selective inhibitor. It acts by significantly enhancing acetylation of tubulin, p53, and histone H4.

Chemical Structure

AC-93253 iodide
CAS# 108527-83-9 (iodide)

Theoretical Analysis

MedKoo Cat#: 563464
Name: AC-93253 iodide
CAS#: 108527-83-9 (iodide)
Chemical Formula: C23H25IN2S
Exact Mass: 488.0783
Molecular Weight: 488.43
Elemental Analysis: C, 56.56; H, 5.16; I, 25.98; N, 5.74; S, 6.56

Price and Availability

Size Price Availability Quantity
10.0mg USD 325.0 2 Weeks
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Related CAS #: 61173-17-9 (cation)   108527-83-9 (iodide)    

Synonym: AC-93253 iodide; AC 93253 iodide; AC93253 iodide;

IUPAC/Chemical Name: 3-ethyl-2-((E)-3-((E)-1,3,3-trimethylindolin-2-ylidene)prop-1-en-1-yl)benzo[d]thiazol-3-ium iodide


InChi Code: InChI=1S/C23H25N2S.HI/c1-5-25-19-13-8-9-14-20(19)26-22(25)16-10-15-21-23(2,3)17-11-6-7-12-18(17)24(21)4;/h6-16H,5H2,1-4H3;1H/q+1;/p-1

SMILES Code: CC[N+]1=C(/C=C/C=C2N(C)C3=C(C=CC=C3)C/2(C)C)SC4=CC=CC=C14.[I-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 488.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lai YH, Lin SY, Wu YS, Chen HW, Chen JJW. AC-93253 iodide, a novel Src inhibitor, suppresses NSCLC progression by modulating multiple Src-related signaling pathways. J Hematol Oncol. 2017 Nov 13;10(1):172. doi: 10.1186/s13045-017-0539-3. PubMed PMID: 29132432; PubMed Central PMCID: PMC5683468.