A-130A

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598568

CAS#: 51257-84-2

Description: A-130A is apolycyclic, polyether cpd belonging to nigericin group of antibiotics produced by Streptomyces hygroscopicus strain.


Price and Availability

Size
Price

Size
Price

Size
Price

A-130A is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 598568
Name: A-130A
CAS#: 51257-84-2
Chemical Formula: C47H78O13
Exact Mass: 850.5442
Molecular Weight: 851.12
Elemental Analysis: C, 66.33; H, 9.24; O, 24.44


Synonym: A-130A; A 130A; A130A; Antibiotic Ro 21 6150; Lenoremycin; Antibiotic A 130A;

IUPAC/Chemical Name: (2S,4R,8S,E)-8-((2S,2'R,4'S,5R,5'R,7S,7'R,9R,10R,10'R)-2'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-9-(((2R,5S,6R)-5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2,4',10,10'-tetramethyl-1,1',6,6'-tetraoxa[2,7'-bispiro[4.5]decan]-7-yl)-2,4,6-trimethyl-5-oxonon-6-enoic acid

InChi Key: LQFPDTISEHAMNQ-JRSQRZRGSA-N

InChi Code: InChI=1S/C47H78O13/c1-25(19-26(2)41(49)27(3)20-29(5)43(50)51)36-23-37(55-40-16-14-35(53-12)34(10)54-40)33(9)46(56-36)18-17-44(11,60-46)39-15-13-30(6)47(58-39)32(8)22-38(57-47)42-28(4)21-31(7)45(52,24-48)59-42/h19,25,27-40,42,48,52H,13-18,20-24H2,1-12H3,(H,50,51)/b26-19+/t25-,27+,28-,29-,30+,31+,32-,33+,34+,35-,36-,37+,38+,39+,40-,42-,44-,45-,46+,47+/m0/s1

SMILES Code: C[C@H]([C@H](O[C@H]1CC[C@H](OC)[C@@H](C)O1)C[C@@H]([C@@H](C)/C=C(C)/C([C@H](C)C[C@@H](C(O)=O)C)=O)O2)[C@]2(O3)CC[C@@]3(C)[C@H]4CC[C@@H](C)[C@]5([C@@H](C)C[C@H]([C@@H]6[C@@H](C)C[C@@H](C)[C@](O)(CO)O6)O5)O4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Mizoue K, Seto H, Mizutani T, Yamagishi M, Kawashima A, Omura S, Ozeki M, Otake N. Studies on the ionophorous antibiotics. XXV. The assignments of the 13C-NMR spectra of dianemycin and lenoremycin. J Antibiot (Tokyo). 1980 Feb;33(2):144-56. PubMed PMID: 7380725.

2: Shaaban KA, Saunders MA, Zhang Y, Tran T, Elshahawi SI, Ponomareva LV, Wang X, Zhang J, Copley GC, Sunkara M, Kharel MK, Morris AJ, Hower JC, Tremblay MS, Prendergast MA, Thorson JS. Spoxazomicin D and Oxachelin C, Potent Neuroprotective Carboxamides from the Appalachian Coal Fire-Associated Isolate Streptomyces sp. RM-14-6. J Nat Prod. 2017 Jan 27;80(1):2-11. doi: 10.1021/acs.jnatprod.6b00948. Epub 2016 Dec 28. PubMed PMID: 28029795; PubMed Central PMCID: PMC5337259.