Valecobulin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 572154

CAS#: 1188371-47-2

Description: Valecobulin is an anti-neoplastic beta-tubulin polymerization inhibitor. Tubulin polymerization inhibitors may be useful in inducing cancer cell apoptosis.


Price and Availability

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Valecobulin, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 572154
Name: Valecobulin
CAS#: 1188371-47-2
Chemical Formula: C26H28N6O5S
Exact Mass: 536.1842
Molecular Weight: 536.61
Elemental Analysis: C, 58.20; H, 5.26; N, 15.66; O, 14.91; S, 5.97


Synonym: Valecobulin

IUPAC/Chemical Name: (2S)-2-amino-3-methyl-N-{4-[3-(1H-1,2,4-triazol-1-yl)- 4-(3,4,5-trimethoxybenzoyl)phenyl]-1,3-thiazol- 2-yl}butanamide

InChi Key: UKKRUIXIDCWALA-QFIPXVFZSA-N

InChi Code: InChI=1S/C26H28N6O5S/c1-14(2)22(27)25(34)31-26-30-18(11-38-26)15-6-7-17(19(8-15)32-13-28-12-29-32)23(33)16-9-20(35-3)24(37-5)21(10-16)36-4/h6-14,22H,27H2,1-5H3,(H,30,31,34)/t22-/m0/s1

SMILES Code: CC(C)[C@H](N)C(NC1=NC(C2=CC=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C(N4N=CN=C4)=C2)=CS1)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Mahale S, Bharate SB, Manda S, Joshi P, Jenkins PR, Vishwakarma RA, Chaudhuri B. Antitumour potential of BPT: a dual inhibitor of cdk4 and tubulin polymerization. Cell Death Dis. 2015 May 7;6:e1743. doi: 10.1038/cddis.2015.96. PubMed PMID: 25950473; PubMed Central PMCID: PMC4669722.

2: Saha A, Mohapatra S, Kurkute P, Jana B, Mondal P, Bhunia D, Ghosh S, Ghosh S. Interaction of Aβ peptide with tubulin causes an inhibition of tubulin polymerization and the apoptotic death of cancer cells. Chem Commun (Camb). 2015 Feb 11;51(12):2249-52. doi: 10.1039/c4cc09390a. PubMed PMID: 25567764.