Dalvastatin

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MedKoo CAT#: 461274

CAS#: 132100-55-1

Description: Dalvastatin is a prodrug which converts to its open hydroxyacid form in the body. It acts as a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-10. Prices are subject to change without notice.

Dalvastatin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 461274
Name: Dalvastatin
CAS#: 132100-55-1
Chemical Formula: C24H31FO3
Exact Mass: 386.2257
Molecular Weight: 386.5
Elemental Analysis: C, 74.58; H, 8.08; F, 4.92; O, 12.42


Synonym: Dalvastatin; RG 12561; RG-12561; RG12561;

IUPAC/Chemical Name: (4S,6R)-6-((E)-2-(4'-fluoro-3,3,3',5,5-pentamethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one

InChi Key: VDSBXXDKCUBMQC-VUOWKATKSA-N

InChi Code: InChI=1S/C24H31FO3/c1-15-10-16(6-9-21(15)25)19-13-23(2,3)14-24(4,5)20(19)8-7-18-11-17(26)12-22(27)28-18/h6-10,17-18,26H,11-14H2,1-5H3/b8-7+/t17-,18-/m0/s1

SMILES Code: O=C1C[C@@H](O)C[C@H](/C=C/C2=C(C3=CC=C(F)C(C)=C3)CC(C)(C)CC2(C)C)O1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Won CM. Epimerization and hydrolysis of dalvastatin, a new hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Pharm Res. 1994 Jan;11(1):165-70. PubMed PMID: 8140049.

2: Amin D, Gustafson SK, Weinacht JM, Cornell SA, Neuenschwander K, Kosmider B, Scotese AC, Regan JR, Perrone MH. RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent. Pharmacology. 1993;46(1):13-22. PubMed PMID: 8434028.

3: Khetarpal VK, Storbeck LS, Wells D, Meacham RH Jr. Method for separation and determination of lactone and hydroxy acid forms of a new HMG CoA reductase inhibitor (RG 12561) in plasma. J Chromatogr. 1991 Jul 5;567(2):491-7. PubMed PMID: 1939482.

4: Ammon HL, Prasad SM, Kumar N. Structure of RG-12561 dichloromethane solvate and a diastereomer. Acta Crystallogr C. 1992 Apr 15;48 ( Pt 4):669-75. PubMed PMID: 1515102.