t-Boc-N-Amido-PEG2-propargyl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 572142

CAS#: 869310-84-9

Description: t-Boc-N-Amido-PEG2-propargyl is a PEG derivative containing a propargyl group and Boc-protected amino group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Structure

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t-Boc-N-Amido-PEG2-propargyl
CAS# 869310-84-9
Instruction

Theoretical Analysis

MedKoo Cat#: 572142
Name: t-Boc-N-Amido-PEG2-propargyl
CAS#: 869310-84-9
Chemical Formula: C12H21NO4
Exact Mass: 243.15
Molecular Weight: 243.300
Elemental Analysis: C, 59.24; H, 8.70; N, 5.76; O, 26.30

Price and Availability

Size Price Availability Quantity
250mg USD 560
500mg USD 830
1g USD 1200
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Synonym: t-Boc-N-Amido-PEG2-propargyl

IUPAC/Chemical Name: tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate

InChi Key: WBOOWEAGRWGHMV-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H21NO4/c1-5-7-15-9-10-16-8-6-13-11(14)17-12(2,3)4/h1H,6-10H2,2-4H3,(H,13,14)

SMILES Code: O=C(OC(C)(C)C)NCCOCCOCC#C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info: The hydrophilic PEG spacer increases solubility in aqueous media.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 243.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. Epub 2014 May 22. PubMed PMID: 24856103; PubMed Central PMCID: PMC4102141.

2: Salmaso S, Bersani S, Scomparin A, Mastrotto F, Scherpfer R, Tonon G, Caliceti P. Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjug Chem. 2009 Jun;20(6):1179-85. doi: 10.1021/bc9000432. PubMed PMID: 19469471.