BW723C86
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563427

CAS#: 160521-72-2

Description: BW723C86 is a 5-HT2B serotonin receptor agonist.


Price and Availability

Size
Price

Size
Price

Size
Price

BW723C86, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 563427
Name: BW723C86
CAS#: 160521-72-2
Chemical Formula: C16H19ClN2OS
Exact Mass: 322.0907
Molecular Weight: 322.85
Elemental Analysis: C, 59.52; H, 5.93; Cl, 10.98; N, 8.68; O, 4.96; S, 9.93


Synonym: BW723C86; BW-723-C-86; BW 723 C 86; BW-723C86; BW 723C86;

IUPAC/Chemical Name: alpha-Methyl-5-(2-thienylmethoxy)-1H-Indole-3-ethanamine monohydrochloride

InChi Key: PYJBJMIBANAOFJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H18N2OS.ClH/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14;/h2-6,8-9,11,18H,7,10,17H2,1H3;1H

SMILES Code: NC(C)CC1=CNC2=C1C=C(OCC3=CC=CS3)C=C2.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Agosto-Marlin IM, Nichols NL, Mitchell GS. Systemic inflammation inhibits serotonin receptor 2-induced phrenic motor facilitation upstream from BDNF/TrkB signaling. J Neurophysiol. 2018 Jun 1;119(6):2176-2185. doi: 10.1152/jn.00378.2017. Epub 2018 Mar 7. PubMed PMID: 29513151; PubMed Central PMCID: PMC6032128.

2: Belmer A, Quentin E, Diaz SL, Guiard BP, Fernandez SP, Doly S, Banas SM, Pitychoutis PM, Moutkine I, Muzerelle A, Tchenio A, Roumier A, Mameli M, Maroteaux L. Positive regulation of raphe serotonin neurons by serotonin 2B receptors. Neuropsychopharmacology. 2018 Jun;43(7):1623-1632. doi: 10.1038/s41386-018-0013-0. Epub 2018 Feb 5. PubMed PMID: 29453444; PubMed Central PMCID: PMC5983540.

3: Liu Y, Wang Z, Li J, Ban Y, Mao G, Zhang M, Wang M, Liu Y, Zhao B, Shen Q, Xu Q, Wang N. Inhibition of 5-Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β-Arrestin2-Mammalian Target of Rapamycin/p70S6K Pathway. J Am Heart Assoc. 2018 Jan 30;7(3). pii: e006810. doi: 10.1161/JAHA.117.006810. PubMed PMID: 29382665; PubMed Central PMCID: PMC5850233.

4: Njie-Mbye YF, Robinson J, Mitchell-Bush L, Mckoy M, Opere CA, Ohia SE, Sharif N. Pharmacology of Serotonin Receptors Causing Contraction of Isolated Bovine Posterior Ciliary Arteries: Role in Ocular Blood Flow. J Ocul Pharmacol Ther. 2018 Jan/Feb;34(1-2):134-140. doi: 10.1089/jop.2017.0124. Epub 2018 Jan 25. PubMed PMID: 29369737.

5: Ohia SE, Njie-Mbye YF, Robinson J, Mitchell L, Mckoy M, Opere CA, Sharif NA. Serotonin-2B/2C Receptors Mediate Bovine Ciliary Muscle Contraction: Role in Intraocular Pressure Regulation. J Ocul Pharmacol Ther. 2018 Jan/Feb;34(1-2):70-75. doi: 10.1089/jop.2017.0123. Epub 2018 Jan 24. PubMed PMID: 29364761.

6: Dahan D, Hien TT, Tannenberg P, Ekman M, Rippe C, Boettger T, Braun T, Tran-Lundmark K, Tran PK, Swärd K, Albinsson S. MicroRNA-Dependent Control of Serotonin-Induced Pulmonary Arterial Contraction. J Vasc Res. 2017;54(4):246-256. doi: 10.1159/000478013. Epub 2017 Aug 11. PubMed PMID: 28796998.

7: Cataldo LR, Mizgier ML, Bravo Sagua R, Jaña F, Cárdenas C, Llanos P, Busso D, Olmos P, Galgani JE, Santos JL, Cortés VA. Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and Mitochondrial Function in MIN6 Cells. PLoS One. 2017 Jan 27;12(1):e0170213. doi: 10.1371/journal.pone.0170213. eCollection 2017. PubMed PMID: 28129327; PubMed Central PMCID: PMC5271329.

8: Mironova GY, Avdonin PP, Goncharov NV, Jenkins RO, Avdonin PV. Inhibition of protein tyrosine phosphatases unmasks vasoconstriction and potentiates calcium signaling in rat aorta smooth muscle cells in response to an agonist of 5-HT2B receptors BW723C86. Biochem Biophys Res Commun. 2017 Jan 29;483(1):700-705. doi: 10.1016/j.bbrc.2016.12.079. Epub 2016 Dec 13. PubMed PMID: 27986565.

9: Park SW, Noh HJ, Kim JM, Kim B, Cho SI, Kim YS, Woo NS, Kim SH, Bae YM. Facilitation of serotonin-induced contraction of rat mesenteric artery by ketamine. Korean J Physiol Pharmacol. 2016 Nov;20(6):605-611. Epub 2016 Oct 28. PubMed PMID: 27847437; PubMed Central PMCID: PMC5106394.

10: Pratt WE, Clissold KA, Lin P, Cain AE, Ciesinski AF, Hopkins TR, Ilesanmi AO, Kelly EA, Pierce-Messick Z, Powell DS, Rosner IA. A systematic investigation of the differential roles for ventral tegmentum serotonin 1- and 2-type receptors on food intake in the rat. Brain Res. 2016 Oct 1;1648(Pt A):54-68. doi: 10.1016/j.brainres.2016.07.016. Epub 2016 Jul 16. PubMed PMID: 27431937; PubMed Central PMCID: PMC5018453.

11: Oh EJ, Park JI, Lee JE, Myung CH, Kim SY, Chang SE, Hwang JS. A Novel Role of Serotonin Receptor 2B Agonist as an Anti-Melanogenesis Agent. Int J Mol Sci. 2016 Apr 12;17(4):546. doi: 10.3390/ijms17040546. PubMed PMID: 27077852; PubMed Central PMCID: PMC4849002.

12: Miwa H, Koseki J, Oshima T, Hattori T, Kase Y, Kondo T, Fukui H, Tomita T, Ohda Y, Watari J. Impairment of gastric accommodation induced by water-avoidance stress is mediated by 5-HT2B receptors. Neurogastroenterol Motil. 2016 May;28(5):765-78. doi: 10.1111/nmo.12775. Epub 2016 Feb 2. PubMed PMID: 26833428.

13: Naito K, Moteki H, Kimura M, Natsume H, Ogihara M. Serotonin 5-HT2B Receptor-Stimulated DNA Synthesis and Proliferation Are Mediated by Autocrine Secretion of Transforming Growth Factor-α in Primary Cultures of Adult Rat Hepatocytes. Biol Pharm Bull. 2016;39(4):570-7. doi: 10.1248/bpb.b15-00923. Epub 2016 Jan 23. PubMed PMID: 26804134.

14: Naito K, Tanaka C, Mitsuhashi M, Moteki H, Kimura M, Natsume H, Ogihara M. Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Biol Pharm Bull. 2016;39(1):121-9. doi: 10.1248/bpb.b15-00735. Epub 2015 Nov 14. PubMed PMID: 26567725.

15: Watts SW, Darios ES, Seitz BM, Thompson JM. 5-HT is a potent relaxant in rat superior mesenteric veins. Pharmacol Res Perspect. 2015 Feb;3(1):e00103. doi: 10.1002/prp2.103. Epub 2015 Jan 5. PubMed PMID: 25692021; PubMed Central PMCID: PMC4317234.

16: Schmitz B, Ullmer C, Segelcke D, Gwarek M, Zhu XR, Lübbert H. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80. doi: 10.1016/j.ejphar.2015.01.043. Epub 2015 Feb 7. PubMed PMID: 25666387.

17: Nadeev AD, Kudryavtsev IV, Serebriakova MK, Avdonin PV, Zinchenko VP, Goncharov NV. [DUAL PROAPOPTOTIC AND PRONECROTIC EFFECT OF HYDROGEN PEROXIDE ON HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS]. Tsitologiia. 2015;57(12):909-16. Russian. PubMed PMID: 26995970.

18: Matsumoto T, Watanabe S, Taguchi K, Kobayashi T. Mechanisms underlying increased serotonin-induced contraction in carotid arteries from chronic type 2 diabetic Goto-Kakizaki rats. Pharmacol Res. 2014 Sep;87:123-32. doi: 10.1016/j.phrs.2014.07.001. Epub 2014 Jul 15. PubMed PMID: 25034165.

19: Pérez Maceira JJ, Mancebo MJ, Aldegunde M. The involvement of 5-HT-like receptors in the regulation of food intake in rainbow trout (Oncorhynchus mykiss). Comp Biochem Physiol C Toxicol Pharmacol. 2014 Apr;161:1-6. doi: 10.1016/j.cbpc.2013.12.003. Epub 2013 Dec 21. PubMed PMID: 24365333.

20: Aira Z, Buesa I, García del Caño G, Bilbao J, Doñate F, Zimmermann M, Azkue JJ. Transient, 5-HT2B receptor-mediated facilitation in neuropathic pain: Up-regulation of PKCγ and engagement of the NMDA receptor in dorsal horn neurons. Pain. 2013 Sep;154(9):1865-77. doi: 10.1016/j.pain.2013.06.009. Epub 2013 Jun 12. PubMed PMID: 23769718.