WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592540

CAS#: 99-20-7

Description: Trehalose prevents sciatic nerve damage to and apoptosis of Schwann cells of streptozotocin-induced diabetic C57BL/6J mice.

Chemical Structure

CAS# 99-20-7

Theoretical Analysis

MedKoo Cat#: 592540
Name: Trehalose
CAS#: 99-20-7
Chemical Formula: C12H22O11
Exact Mass: 342.12
Molecular Weight: 342.297
Elemental Analysis: C, 42.11; H, 6.48; O, 51.41

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Trehalose; NSC 2093; NSC-2093; NSC2093

IUPAC/Chemical Name: alpha-D-Glucopyranoside, alpha-D-glucopyranosyl


InChi Code: InChI=1S/C12H22O11/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-/m1/s1

SMILES Code: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 342.297000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ngamcherdtrakul W, Sangvanich T, Reda M, Gu S, Bejan D, Yantasee W. Lyophilization and stability of antibody-conjugated mesoporous silica nanoparticle with cationic polymer and PEG for siRNA delivery. Int J Nanomedicine. 2018 Jul 10;13:4015-4027. doi: 10.2147/IJN.S164393. eCollection 2018. PubMed PMID: 30022824; PubMed Central PMCID: PMC6045907. 2: Pan H, Ding Y, Yan N, Nie Y, Li M, Tong L. Trehalose prevents sciatic nerve damage to and apoptosis of Schwann cells of streptozotocin-induced diabetic C57BL/6J mice. Biomed Pharmacother. 2018 Sep;105:907-914. doi: 10.1016/j.biopha.2018.06.069. Epub 2018 Jun 19. PubMed PMID: 30021384. 3: Shen T, Cai LD, Liu YH, Li S, Gan WJ, Li XM, Wang JR, Guo PD, Zhou Q, Lu XX, Sun LN, Li JM. Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy. J Hematol Oncol. 2018 Jul 17;11(1):95. doi: 10.1186/s13045-018-0638-9. PubMed PMID: 30016968; PubMed Central PMCID: PMC6050692. 4: Magrì A, Grasso G, Corti F, Finetti F, Greco V, Santoro AM, Sciuto S, La Mendola D, Morbidelli L, Rizzarelli E. Peptides derived from the histidine-proline rich glycoprotein bind copper ions and exhibit anti-angiogenic properties. Dalton Trans. 2018 Jul 17;47(28):9492-9503. doi: 10.1039/c8dt01560k. PubMed PMID: 29963662. 5: Kim JH, Shin DH, Kim JS. Preparation, characterization, and pharmacokinetics of liposomal docetaxel for oral administration. Arch Pharm Res. 2018 Jun 30. doi: 10.1007/s12272-018-1046-y. [Epub ahead of print] PubMed PMID: 29961194. 6: Li H, Bian YL, Schreurs N, Zhang XG, Raza SHA, Fang Q, Wang LQ, Hu JH. Effects of five cryoprotectants on proliferation and differentiation-related gene expression of frozen-thawed bovine calf testicular tissue. Reprod Domest Anim. 2018 Jun 28. doi: 10.1111/rda.13228. [Epub ahead of print] PubMed PMID: 29956384. 7: Mosaiab T, Boiteux S, Zulfiker AHM, Wei MQ, Kiefel MJ, Houston TA. A Simple Glycolipid Mimic of the Phosphatidylinositol Mannoside Core from Mycobacterium tuberculosis Inhibits Macrophage Cytokine Production. Chembiochem. 2018 Apr 25. doi: 10.1002/cbic.201800150. [Epub ahead of print] PubMed PMID: 29693771. 8: Hosseinpour-Moghaddam K, Caraglia M, Sahebkar A. Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts. J Cell Physiol. 2018 Sep;233(9):6524-6543. doi: 10.1002/jcp.26583. Epub 2018 Apr 16. Review. PubMed PMID: 29663416. 9: Gan Q, Zhang X, Zhang D, Shi L, Zhou Y, Sun T, Jiang S, Gao J, Meng Y. BmSUC1 is essential for glycometabolism modulation in the silkworm, Bombyx mori. Biochim Biophys Acta. 2018 Jun;1861(6):543-553. doi: 10.1016/j.bbagrm.2018.04.002. Epub 2018 Apr 14. PubMed PMID: 29660529. 10: Jafarpour SM, Safaei M, Mohseni M, Salimian M, Aliasgharzadeh A, Fahood B. The Radioprotective Effects of Curcumin and Trehalose Against Genetic Damage Caused By I-131. Indian J Nucl Med. 2018 Apr-Jun;33(2):99-104. doi: 10.4103/ijnm.IJNM_158_17. Erratum in: Indian J Nucl Med. 2018 Jul-Sep;33(3):268. PubMed PMID: 29643668; PubMed Central PMCID: PMC5883450. 11: Liu D, Chan BC, Cheng L, Tsang MS, Zhu J, Wong CW, Jiao D, Chan HY, Leung PC, Lam CW, Wong CK. Sophora flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages. Sci Rep. 2018 Mar 2;8(1):3903. doi: 10.1038/s41598-018-22286-w. PubMed PMID: 29500453; PubMed Central PMCID: PMC5834626. 12: Chen S, Zhou Y, Zhou L, Guan Y, Zhang Y, Han X. Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway. Mol Cell Biochem. 2018 Feb 14. doi: 10.1007/s11010-018-3328-6. [Epub ahead of print] PubMed PMID: 29446046. 13: Mizunoe Y, Kobayashi M, Sudo Y, Watanabe S, Yasukawa H, Natori D, Hoshino A, Negishi A, Okita N, Komatsu M, Higami Y. Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways. Redox Biol. 2018 May;15:115-124. doi: 10.1016/j.redox.2017.09.007. Epub 2017 Sep 20. PubMed PMID: 29241092; PubMed Central PMCID: PMC5730428. 14: Acar D, Molina-Martínez IT, Gómez-Ballesteros M, Guzmán-Navarro M, Benítez-Del-Castillo JM, Herrero-Vanrell R. Novel liposome-based and in situ gelling artificial tear formulation for dry eye disease treatment. Cont Lens Anterior Eye. 2018 Feb;41(1):93-96. doi: 10.1016/j.clae.2017.11.004. Epub 2017 Dec 6. PubMed PMID: 29223649. 15: Hurwitz SN, Cheerathodi MR, Nkosi D, York SB, Meckes DG Jr. Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1. J Virol. 2018 Feb 12;92(5). pii: e01969-17. doi: 10.1128/JVI.01969-17. Print 2018 Mar 1. PubMed PMID: 29212935; PubMed Central PMCID: PMC5809724. 16: Li S, Zhang Q, Zhou L, Guan Y, Chen S, Zhang Y, Han X. Inhibitory effects of compound DMBT on hypoxia-induced vasculogenic mimicry in human breast cancer. Biomed Pharmacother. 2017 Dec;96:982-992. doi: 10.1016/j.biopha.2017.11.137. Epub 2017 Dec 6. PubMed PMID: 29208325. 17: Neo SH, Chung KY, Quek JM, Too HP. Trehalose significantly enhances the recovery of serum and serum exosomal miRNA from a paper-based matrix. Sci Rep. 2017 Nov 30;7(1):16686. doi: 10.1038/s41598-017-16960-8. PubMed PMID: 29192155; PubMed Central PMCID: PMC5709463. 18: Mollaev M, Gorokhovets N, Nikolskaya E, Faustova M, Zabolotsky A, Sokol M, Tereshenko O, Zhunina O, Shvets V, Severin E, Yabbarov N. Recombinant alpha-fetoprotein receptor-binding domain co-expression with polyglutamate tags facilitates in vivo folding in E. coli. Protein Expr Purif. 2018 Mar;143:77-82. doi: 10.1016/j.pep.2017.11.001. Epub 2017 Nov 7. PubMed PMID: 29127003. 19: Bínová E, Bína D, Ashford DA, Thomas-Oates J, Nohýnková E. Trehalose During Two Stress Responses in Acanthamoeba: Differentiation Between Encystation and Pseudocyst Formation. Protist. 2017 Dec;168(6):649-662. doi: 10.1016/j.protis.2017.09.001. Epub 2017 Sep 14. PubMed PMID: 29100111. 20: Ichihara H, Kuwabara K, Matsumoto Y. Trehalose Liposomes Suppress the Growth of Tumors on Human Lung Carcinoma-bearing Mice by Induction of Apoptosis In Vivo. Anticancer Res. 2017 Nov;37(11):6133-6139. PubMed PMID: 29061794.