Fenclorac

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592535

CAS#: 36616-52-1

Description: Fenclorac has anti-inflammatory properties.

Chemical Structure

img
Fenclorac
CAS# 36616-52-1
Instruction

Theoretical Analysis

MedKoo Cat#: 592535
Name: Fenclorac
CAS#: 36616-52-1
Chemical Formula: C14H16Cl2O2
Exact Mass: 286.05
Molecular Weight: 287.180
Elemental Analysis: C, 58.55; H, 5.62; Cl, 24.69; O, 11.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Fenclorac

IUPAC/Chemical Name: Acetic acid, 2-chloro-2-(3-chloro-4-cyclohexylphenyl)-

InChi Key: GXEUNRBWEAIPCN-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H16Cl2O2/c15-12-8-10(13(16)14(17)18)6-7-11(12)9-4-2-1-3-5-9/h6-9,13H,1-5H2,(H,17,18)

SMILES Code: O=C(O)C(Cl)C1=CC=C(C2CCCCC2)C(Cl)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 287.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Talesnik J, Hsia JC. Coronary flow reactions to arachidonic acid are inhibited by docosahexaenoic acid. Eur J Pharmacol. 1982 May 21;80(2-3):255-8. PubMed PMID: 6213418.

2: Mathur PP, Smyth RD. Physiological disposition and subcellular localization of 14C-fenclorac in the rat. Res Commun Chem Pathol Pharmacol. 1979 Jul;25(1):23-31. PubMed PMID: 451357.

3: DeLong AF, Polk A, Martin G, Smyth RD, Reavey-Cantwell NH. GLC assay of fenclorac in human plasma. J Pharm Sci. 1978 Aug;67(8):1171-3. PubMed PMID: 307596.

4: Mathur PP, Riley RL, Richardson CP, Reavey-Cantwell NH. The inhibition of prostaglandin synthetase in vivo by nonsteroidal anti-inflammatory agents. Agents Actions. 1977 Jul;7(2):283-8. PubMed PMID: 409117.

5: Lee JK, Smyth RD, Polk A, Herczeg T, Tsuei CT, Reavey-Cantwell NH. Quantitative determination of fenclorac in serum. J Pharm Sci. 1977 Jun;66(6):832-4. PubMed PMID: 301563.

6: Procaccini RL, Smyth RD, Reavey-Cantwell NH. Studies on the in vitro inhibition of prostaglandin synthetase by fenclorac (alpha, m-dichloro-p-cyclohexylphenylacetic acid) and indomethacin. Biochem Pharmacol. 1977 Jun 1;26(11):1051-7. PubMed PMID: 18151.

7: DeLong AF, Smyth RD, Polk A, Nayak RK, Martin G, Douglas GH, Reavey-Cantiwell NH. Comparative metabolism of fenclorac in rat, dog, monkey, and man. Drug Metab Dispos. 1977 Mar-Apr;5(2):122-31. PubMed PMID: 15804.

8: Won CM, Zalipsky JJ, Patel DM, Reavey-Cantwell NH. Kinetics of hydrolysis of fenclorac. J Pharm Sci. 1977 Jan;66(1):73-7. PubMed PMID: 13197.

9: Smyth RD, Mathur PP, Procaccini RL, Carr GS, Reavey-Cantwell NH. Comparative effects of fenclorac and indomethacin on gastrointestinal blood loss in the rat. Toxicol Appl Pharmacol. 1976 Dec;38(3):507-15. PubMed PMID: 1087763.

10: Nuss GW, Smyth RD, Breder CH, Hitchings MJ, Mir GN, Reavey-Cantwell NH. The antiphlogistic, antinociceptive and antipyretic properties of fenclorac. Agents Actions. 1976 Nov;6(6):735-47. PubMed PMID: 1008019.

11: Visalli AJ, Patel DM, Reavey-Cantwell NH. GLC assay for fenclorac. J Pharm Sci. 1976 Nov;65(11):1686-8. PubMed PMID: 994003.

12: Yellin TO, Buck SH, Sperow JW. Inhibition of the diarrheal and cardiac actions of arachidonic acid by fenclorac, a new anti-inflammatory agent. Life Sci. 1976 Oct 15;19(8):1211-6. PubMed PMID: 994722.