Laurifoline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598453

CAS#: 7224-61-5

Description: Laurifoline is a potential NF-κB inhibitor.

Chemical Structure

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Laurifoline
CAS# 7224-61-5
Instruction

Theoretical Analysis

MedKoo Cat#: 598453
Name: Laurifoline
CAS#: 7224-61-5
Chemical Formula: C20H24NO4
Exact Mass: 342.17
Molecular Weight: 342.410
Elemental Analysis: C, 70.15; H, 7.07; N, 4.09; O, 18.69

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Laurifoline;

IUPAC/Chemical Name: (S)-1,9-dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium

InChi Key: ZDVDVLRYVOZWMP-AWEZNQCLSA-O

InChi Code: InChI=1S/C20H23NO4/c1-21(2)6-5-11-9-17(25-4)20(23)19-13-10-16(24-3)15(22)8-12(13)7-14(21)18(11)19/h8-10,14H,5-7H2,1-4H3,(H-,22,23)/p+1/t14-/m0/s1

SMILES Code: C[N+]1(C)CCC2=CC(OC)=C(O)C3=C2[C@]1([H])CC4=CC(O)=C(OC)C=C34

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 342.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sun D, Han Y, Wang W, Wang Z, Ma X, Hou Y, Bai G. Screening and identification of Caulis Sinomenii bioactive ingredients with dual-target NF-κB inhibition and β(2-) AR agonizing activities. Biomed Chromatogr. 2016 Nov;30(11):1843-1853. doi: 10.1002/bmc.3761. Epub 2016 Jun 16. PubMed PMID: 27187693.

2: KIKKAWA I, TOMITA M. Studies on the alkaloids of menispermaceous plants. CXXXIV. Alkaloids of Cocculus laurifolius DC. (suppl. 8), syntheses of di-coclanoline and di-laurifoline. Pharm Bull. 1956 Aug;4(4):230-6. PubMed PMID: 13378942.

3: Tomko J, Awad AT, Beal JL, Doskotch RW. Isolation of candicine chloride, laurifoline chloride, and xanthoxyletin from the bark of Zanthoxylum elephantiasis. J Pharm Sci. 1968 Feb;57(2):329-30. PubMed PMID: 5641685.

4: Yi L, Liang ZT, Peng Y, Yao X, Chen HB, Zhao ZZ. Tissue-specific metabolite profiling of alkaloids in Sinomenii Caulis using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry. J Chromatogr A. 2012 Jul 27;1248:93-103. doi: 10.1016/j.chroma.2012.05.058. Epub 2012 May 24. PubMed PMID: 22721764.

5: Cheng P, Ma YB, Yao SY, Zhang Q, Wang EJ, Yan MH, Zhang XM, Zhang FX, Chen JJ. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5316-20. Epub 2007 Aug 16. PubMed PMID: 17723297.