Laudexium methylsulfate

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MedKoo CAT#: 598439

CAS#: 3253-60-9

Description: Laudexium methylsulfate is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in surgical anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.


Chemical Structure

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Laudexium methylsulfate
CAS# 3253-60-9

Theoretical Analysis

MedKoo Cat#: 598439
Name: Laudexium methylsulfate
CAS#: 3253-60-9
Chemical Formula: C54H80N2O16S2
Exact Mass: 0.00
Molecular Weight: 1,077.350
Elemental Analysis: C, 60.20; H, 7.49; N, 2.60; O, 23.76; S, 5.95

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Laudexium methylsulfate; Laudexium; Laudolissin methosulphate;

IUPAC/Chemical Name: 2,2'-(decane-1,10-diyl)bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) methyl sulfate

InChi Key: LADQAYSLFLCKOD-UHFFFAOYSA-L

InChi Code: InChI=1S/C52H74N2O8.2CH4O4S/c1-53(27-23-39-33-49(59-7)51(61-9)35-41(39)43(53)29-37-19-21-45(55-3)47(31-37)57-5)25-17-15-13-11-12-14-16-18-26-54(2)28-24-40-34-50(60-8)52(62-10)36-42(40)44(54)30-38-20-22-46(56-4)48(32-38)58-6;2*1-5-6(2,3)4/h19-22,31-36,43-44H,11-18,23-30H2,1-10H3;2*1H3,(H,2,3,4)/q+2;;/p-2

SMILES Code: COC1=CC(CC2[N+](CCCCCCCCCC[N+]3(C)C(CC4=CC=C(OC)C(OC)=C4)C5=C(C=C(OC)C(OC)=C5)CC3)(C)CCC6=C2C=C(OC)C(OC)=C6)=CC=C1OC.O=S(OC)([O-])=O.O=S(OC)([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,077.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: BRITTAIN RT, CHESHER BG, COLLIER HO, GRIMSHAW JJ. Assay of suxamethonium and laudexium on the frog rectus abdominis. Br J Pharmacol Chemother. 1959 Jun;14(2):158-63. PubMed PMID: 13662566; PubMed Central PMCID: PMC1481804.

2: COLLIER HO, MACAULEY B. The effects on animals of large doses of laudexium methylsulphate. Br J Anaesth. 1954 Jul;26(4):237-44. PubMed PMID: 13172370.

3: BROWN LH. Failure to detect anticholinesterase activity in laudexium methylsulphate. Br J Anaesth. 1954 Jul;26(4):244-5. PubMed PMID: 13172371.

4: HUNTER AR. The action of laudexium in man and experimental animals. Br J Anaesth. 1955 Feb;27(2):73-9. PubMed PMID: 13230365.

5: STEAD AL, ANDREWS WH. The role of the canine liver in the detoxication of d-tubocurarine chloride, gallamine triethiodide and laudexium. Br J Anaesth. 1957 Apr;29(4):151-5. PubMed PMID: 13426356.