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MedKoo CAT#: 598418

CAS#: 121650-80-4

Description: Pancopride is a selective 5-HT3 receptor antagonist; effective against anticancer drug-evoked emesis.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-15. Prices are subject to change without notice.

Pancopride is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 598418
Name: Pancopride
CAS#: 121650-80-4
Chemical Formula: C18H24ClN3O2
Exact Mass: 349.1557
Molecular Weight: 349.85
Elemental Analysis: C, 61.80; H, 6.91; Cl, 10.13; N, 12.01; O, 9.15

Synonym: Pancopride; Pancopridum; LAS 30451; LAS-30451; LAS30451;

IUPAC/Chemical Name: 4-amino-5-chloro-2-(cyclopropylmethoxy)-N-(quinuclidin-3-yl)benzamide


InChi Code: InChI=1S/C18H24ClN3O2/c19-14-7-13(17(8-15(14)20)24-10-11-1-2-11)18(23)21-16-9-22-5-3-12(16)4-6-22/h7-8,11-12,16H,1-6,9-10,20H2,(H,21,23)


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Dewland P, Pérez Campos A, Martinez-Tobed A. Single dose pharmacokinetics and tolerance of pancopride in healthy volunteers. Arzneimittelforschung. 1995 Feb;45(2):177-83. PubMed PMID: 7710444.

2: Grande L, Lacima G, Pérez A, Zayas JM. Lack of effect of a 5-HT3 antagonist, pancopride, on lower oesophageal sphincter pressure in volunteers. Br J Clin Pharmacol. 1995 Oct;40(4):401-3. PubMed PMID: 8554943; PubMed Central PMCID: PMC1365160.

3: Fernández AG, Puig J, Beleta J, Doménech T, Bou J, Berga P, Gristwood RW, Roberts DJ. Pancopride, a potent and long-acting 5-HT3 receptor antagonist, is orally effective against anticancer drug-evoked emesis. Eur J Pharmacol. 1992 Nov 10;222(2-3):257-64. PubMed PMID: 1451737.

4: Salva P, Costa J, Pérez-Campos A, Martínez-Tobed A. Repeated dose pharmacokinetics of pancopride in human volunteers. Biopharm Drug Dispos. 1994 Nov;15(8):643-51. PubMed PMID: 7888596.

5: Aranda E, Barneto IC, Rubio MJ, Gonzalez R, Garcia A, Perez A. Prevention of highly emetogenic chemotherapy-induced vomiting: a double blind, randomized crossover study to compare pancopride (LAS 30451) and pancopride plus dexamethasone. Tumori. 1995 Nov-Dec;81(6):432-4. PubMed PMID: 8804470.

6: Pérez Campos A. [The clinical development of an antiemetic in oncology. A meta-analysis]. Med Clin (Barc). 1994 Sep 17;103(8):281-6. Spanish. PubMed PMID: 7967877.

7: Martin M, Rosell R, Guillem V, Díaz-Rubio E, Moreno I, Soriano V, Fernández A, Pérez A. LAS 30451: a novel 5-HT3 antagonist. Eur J Cancer. 1993;29A Suppl 1:S33-4. PubMed PMID: 8427723.