Lantadene B

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598379

CAS#: 467-82-3

Description: Lantadene B is an active principle of Lantana camara L.


Price and Availability

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Lantadene B is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 598379
Name: Lantadene B
CAS#: 467-82-3
Chemical Formula: C35H52O5
Exact Mass: 552.3815
Molecular Weight: 552.79
Elemental Analysis: C, 76.05; H, 9.48; O, 14.47


Synonym: Lantadene B; HSDB 3504;

IUPAC/Chemical Name: (4R,4aS,6aS,6bR,8aR,12aR,12bR,14bS)-2,2,6a,6b,9,9,12a-heptamethyl-4-((3-methylbut-2-enoyl)oxy)-10-oxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid

InChi Key: VYPAPFHUHDWCBI-QQAPFUPGSA-N

InChi Code: InChI=1S/C35H52O5/c1-21(2)18-28(37)40-27-20-30(3,4)19-23-22-10-11-25-32(7)14-13-26(36)31(5,6)24(32)12-15-34(25,9)33(22,8)16-17-35(23,27)29(38)39/h10,18,23-25,27H,11-17,19-20H2,1-9H3,(H,38,39)/t23-,24-,25+,27+,32-,33+,34+,35-/m0/s1

SMILES Code: CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)C[C@@H](OC(/C=C(C)\C)=O)[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: LOUW PG. Lantadene A, the active principle of Lantana camara L.; isolation of lantadene B, and the oxygen functions of lantadene A and lantadene B. Onderstepoort J Vet Sci Anim Ind. 1948 Mar;23(1-2):233-8. PubMed PMID: 18863442.

2: Dong Y, Zhang M, Ling B. [Antifeeding effects of crude lantadene from Lantana camara on Plutella xylostella and Spodoptera litura larvae]. Ying Yong Sheng Tai Xue Bao. 2005 Dec;16(12):2361-4. Chinese. PubMed PMID: 16515188.

3: Tailor NK, Jaiswal V, Lan SS, Lee HB, Sharma M. Synthesis, selective cancer cytotoxicity and mechanistic studies of novel analogs of lantadenes. Anticancer Agents Med Chem. 2013 Jul 1;13(6):957-66. PubMed PMID: 23293887.

4: Tailor NK, Boon HL, Sharma M. Synthesis and in vitro anticancer studies of novel C-2 arylidene congeners of lantadenes. Eur J Med Chem. 2013 Jun;64:285-91. doi: 10.1016/j.ejmech.2013.04.009. Epub 2013 Apr 10. PubMed PMID: 23644211.

5: Sharma S, Sharma OP, Singh B, Bhat TK. Biotransformation of lantadenes, the pentacyclic triterpenoid hepatotoxins of lantana plant, in guinea pig. Toxicon. 2000 Sep;38(9):1191-202. PubMed PMID: 10736473.

6: Sharma OP, Dawra RK, Makkar HP. Toxicity of isolated Lantana (Lantana camara L) constituents to male and female guinea pigs. Vet Hum Toxicol. 1989 Feb;31(1):10-3. PubMed PMID: 2711601.