Ganodermic acid S

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MedKoo CAT#: 598363

CAS#: 112430-63-4

Description: Ganodermic acid S, a membrane acting agent, exerts multiple effects on human platelet function. Ganodermic acid S is isolated from the Chinese medicinal fungus Ganoderma lucidum.

Chemical Structure

Ganodermic acid S
CAS# 112430-63-4

Theoretical Analysis

MedKoo Cat#: 598363
Name: Ganodermic acid S
CAS#: 112430-63-4
Chemical Formula: C34H50O6
Exact Mass: 554.3607
Molecular Weight: 554.76
Elemental Analysis: C, 73.61; H, 9.08; O, 17.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Ganodermic acid S; Ganoderic acid R;

IUPAC/Chemical Name: (R,E)-6-((3S,5R,10S,13R,14R,15S,17R)-3,15-diacetoxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylhept-2-enoic acid


InChi Code: InChI=1S/C34H50O6/c1-20(11-10-12-21(2)30(37)38)26-19-29(40-23(4)36)34(9)25-13-14-27-31(5,6)28(39-22(3)35)16-17-32(27,7)24(25)15-18-33(26,34)8/h12-13,15,20,26-29H,10-11,14,16-19H2,1-9H3,(H,37,38)/b21-12+/t20-,26-,27+,28+,29+,32-,33-,34-/m1/s1

SMILES Code: CC1(C)[C@@H](OC(C)=O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC/C=C(C)/C(O)=O)C[C@H](OC(C)=O)[C@](C)4C3=CC[C@@]12[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 554.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Su CY, Shiao MS, Wang CT. Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets. Biochem Pharmacol. 1999 Aug 15;58(4):587-95. PubMed PMID: 10413295.

2: Su C, Shiao M, Wang C. Potentiation of ganodermic acid S on prostaglandin E(1)-induced cyclic AMP elevation in human platelets. Thromb Res. 2000 Jul 15;99(2):135-45. PubMed PMID: 10946087.

3: Wang CN, Chen JC, Shiao MS, Wang CT. The effect of ganodermic acid S on human platelets. Adv Exp Med Biol. 1990;281:265-9. PubMed PMID: 1966354.

4: Wang CN, Chen JC, Shiao MS, Wang CT. The aggregation of human platelet induced by ganodermic acid S. Biochim Biophys Acta. 1989 Nov 17;986(1):151-60. PubMed PMID: 2819092.

5: Su CY, Shiao MS, Wang CT. Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen. Biochim Biophys Acta. 1999 Feb 25;1437(2):223-34. PubMed PMID: 10064905.

6: Wang CN, Chen JC, Shiao MS, Wang CT. The inhibition of human platelet function by ganodermic acids. Biochem J. 1991 Jul 1;277 ( Pt 1):189-97. PubMed PMID: 1649599; PubMed Central PMCID: PMC1151209.

7: Wang FS, Cai H, Yang JS, Zhang YM, Hou CY, Liu JQ, Zhao MJ. [Studies on the ganoderic acid, a new constituents from the fruiting body of Ganoderma lucidum (Fr.) Karst]. Yao Xue Xue Bao. 1997 Jun;32(6):447-50. Chinese. PubMed PMID: 11596326.

8: Tang YJ, Zhong JJ. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnol Prog. 2003 Nov-Dec;19(6):1842-6. PubMed PMID: 14656165.

9: Fang QH, Zhong JJ. Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum. Biotechnol Prog. 2002 Jan-Feb;18(1):51-4. PubMed PMID: 11822899.

10: Chen RY, Yu DQ. [Progress of studies on the chemical constituents of Ganoderma triterpene]. Yao Xue Xue Bao. 1990;25(12):940-53. Review. Chinese. PubMed PMID: 2104477.

11: Kwok Y, Ng KF, Li CC, Lam CC, Man RY. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg. 2005 Aug;101(2):423-6, table of contents. PubMed PMID: 16037156.