Ganodermic acid S

We are open as normal during COVID-19 pandemic. Order online, same day shipping out.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598363

CAS#: 112430-63-4

Description: Ganodermic acid S, a membrane acting agent, exerts multiple effects on human platelet function. Ganodermic acid S is isolated from the Chinese medicinal fungus Ganoderma lucidum.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-03-29. Prices are subject to change without notice.

Ganodermic acid S is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 598363
Name: Ganodermic acid S
CAS#: 112430-63-4
Chemical Formula: C34H50O6
Exact Mass: 554.3607
Molecular Weight: 554.76
Elemental Analysis: C, 73.61; H, 9.08; O, 17.30


Synonym: Ganodermic acid S; Ganoderic acid R;

IUPAC/Chemical Name: (R,E)-6-((3S,5R,10S,13R,14R,15S,17R)-3,15-diacetoxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylhept-2-enoic acid

InChi Key: OTUZGGSAOMCYNC-CRTLAZRUSA-N

InChi Code: InChI=1S/C34H50O6/c1-20(11-10-12-21(2)30(37)38)26-19-29(40-23(4)36)34(9)25-13-14-27-31(5,6)28(39-22(3)35)16-17-32(27,7)24(25)15-18-33(26,34)8/h12-13,15,20,26-29H,10-11,14,16-19H2,1-9H3,(H,37,38)/b21-12+/t20-,26-,27+,28+,29+,32-,33-,34-/m1/s1

SMILES Code: CC1(C)[C@@H](OC(C)=O)CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC/C=C(C)/C(O)=O)C[C@H](OC(C)=O)[C@](C)4C3=CC[C@@]12[H]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Su CY, Shiao MS, Wang CT. Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets. Biochem Pharmacol. 1999 Aug 15;58(4):587-95. PubMed PMID: 10413295.

2: Su C, Shiao M, Wang C. Potentiation of ganodermic acid S on prostaglandin E(1)-induced cyclic AMP elevation in human platelets. Thromb Res. 2000 Jul 15;99(2):135-45. PubMed PMID: 10946087.

3: Wang CN, Chen JC, Shiao MS, Wang CT. The effect of ganodermic acid S on human platelets. Adv Exp Med Biol. 1990;281:265-9. PubMed PMID: 1966354.

4: Wang CN, Chen JC, Shiao MS, Wang CT. The aggregation of human platelet induced by ganodermic acid S. Biochim Biophys Acta. 1989 Nov 17;986(1):151-60. PubMed PMID: 2819092.

5: Su CY, Shiao MS, Wang CT. Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen. Biochim Biophys Acta. 1999 Feb 25;1437(2):223-34. PubMed PMID: 10064905.

6: Wang CN, Chen JC, Shiao MS, Wang CT. The inhibition of human platelet function by ganodermic acids. Biochem J. 1991 Jul 1;277 ( Pt 1):189-97. PubMed PMID: 1649599; PubMed Central PMCID: PMC1151209.

7: Wang FS, Cai H, Yang JS, Zhang YM, Hou CY, Liu JQ, Zhao MJ. [Studies on the ganoderic acid, a new constituents from the fruiting body of Ganoderma lucidum (Fr.) Karst]. Yao Xue Xue Bao. 1997 Jun;32(6):447-50. Chinese. PubMed PMID: 11596326.

8: Tang YJ, Zhong JJ. Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum. Biotechnol Prog. 2003 Nov-Dec;19(6):1842-6. PubMed PMID: 14656165.

9: Fang QH, Zhong JJ. Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum. Biotechnol Prog. 2002 Jan-Feb;18(1):51-4. PubMed PMID: 11822899.

10: Chen RY, Yu DQ. [Progress of studies on the chemical constituents of Ganoderma triterpene]. Yao Xue Xue Bao. 1990;25(12):940-53. Review. Chinese. PubMed PMID: 2104477.

11: Kwok Y, Ng KF, Li CC, Lam CC, Man RY. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg. 2005 Aug;101(2):423-6, table of contents. PubMed PMID: 16037156.