Parkeyl acetate

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MedKoo CAT#: 598348

CAS#: 55570-91-7

Description: Parkeyl acetate is a bioactive chemical.


Price and Availability

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Pricing updated 2020-07-10. Prices are subject to change without notice.

Parkeyl acetate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 598348
Name: Parkeyl acetate
CAS#: 55570-91-7
Chemical Formula: C32H52O2
Exact Mass: 468.3967
Molecular Weight: 468.76
Elemental Analysis: C, 81.99; H, 11.18; O, 6.83


Synonym: Parkeyl acetate;

IUPAC/Chemical Name: (3S,5R,8S,10S,13R,14S,17R)-4,4,10,13,14-pentamethyl-17-((R)-6-methylhept-5-en-2-yl)-2,3,4,5,6,7,8,10,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

InChi Key: LUYVRICDGSTYQC-ALOSQCKVSA-N

InChi Code: InChI=1S/C32H52O2/c1-21(2)11-10-12-22(3)24-15-19-32(9)26-13-14-27-29(5,6)28(34-23(4)33)17-18-30(27,7)25(26)16-20-31(24,32)8/h11,16,22,24,26-28H,10,12-15,17-20H2,1-9H3/t22-,24-,26-,27+,28+,30-,31-,32+/m1/s1

SMILES Code: CC(O[C@H]1CC[C@]2(C)C3=CC[C@]4(C)[C@@H]([C@H](C)CC/C=C(C)\C)CC[C@](C)4[C@]3([H])CC[C@]([H])2C1(C)C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

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2: Ferro S, Azevedo-Silva J, Casal M, Côrte-Real M, Baltazar F, Preto A. Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications. Oncotarget. 2016 Sep 21;7(43):70639-70653. doi: 10.18632/oncotarget.12156. eCollection 2016 Oct 25. PubMed PMID: 28874966; PubMed Central PMCID: PMC5342580.

3: Zeng L, Tang W, Yin J, Feng L, Li Y, Yao X, Zhou B. Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells. Cell Physiol Biochem. 2016;40(3-4):453-464. Epub 2016 Nov 25. PubMed PMID: 27889747.

4: Pfortmueller CA, Fleischmann E. Acetate-buffered crystalloid fluids: Current knowledge, a systematic review. J Crit Care. 2016 Oct;35:96-104. doi: 10.1016/j.jcrc.2016.05.006. Epub 2016 May 12. Review. PubMed PMID: 27481742.

5: Chan SH, Nørregaard L, Solem C, Jensen PR. Acetate kinase isozymes confer robustness in acetate metabolism. PLoS One. 2014 Mar 17;9(3):e92256. doi: 10.1371/journal.pone.0092256. eCollection 2014. PubMed PMID: 24638105; PubMed Central PMCID: PMC3956926.

6: McKeage K. Glatiramer Acetate 40 mg/mL in Relapsing-Remitting Multiple Sclerosis: A Review. CNS Drugs. 2015 May;29(5):425-32. doi: 10.1007/s40263-015-0245-z. Review. PubMed PMID: 25906331.

7: Crowell SR, Smith JN, Creim JA, Faber W, Teeguarden JG. Physiologically based pharmacokinetic modeling of ethyl acetate and ethanol in rodents and humans. Regul Toxicol Pharmacol. 2015 Oct;73(1):452-62. doi: 10.1016/j.yrtph.2015.07.021. Epub 2015 Aug 18. PubMed PMID: 26297692.

8: Sánchez-de la Rosa R, García-Bujalance L, Meca-Lallana J. Cost analysis of glatiramer acetate versus interferon-β for relapsing-remitting multiple sclerosis in patients with spasticity: the Escala study. Health Econ Rev. 2015 Dec;5(1):30. doi: 10.1186/s13561-015-0066-2. Epub 2015 Oct 16. PubMed PMID: 26475277; PubMed Central PMCID: PMC4608957.

9: Keating GM. Eslicarbazepine acetate: a review of its use as adjunctive therapy in refractory partial-onset seizures. CNS Drugs. 2014 Jul;28(7):583-600. doi: 10.1007/s40263-014-0182-2. Review. PubMed PMID: 24972948.

10: Bhatt DP, Rosenberger TA. Acetate treatment increases fatty acid content in LPS-stimulated BV2 microglia. Lipids. 2014 Jul;49(7):621-31. doi: 10.1007/s11745-014-3911-x. Epub 2014 May 23. PubMed PMID: 24852320.

11: Atci E, Babauta JT, Sultana ST, Beyenal H. Microbiosensor for the detection of acetate in electrode-respiring biofilms. Biosens Bioelectron. 2016 Jul 15;81:517-523. doi: 10.1016/j.bios.2016.03.027. Epub 2016 Mar 15. PubMed PMID: 27016913; PubMed Central PMCID: PMC5108365.

12: Moriyama M, Kurebayashi R, Kawabe K, Takano K, Nakamura Y. Acetate Attenuates Lipopolysaccharide-Induced Nitric Oxide Production Through an Anti-Oxidative Mechanism in Cultured Primary Rat Astrocytes. Neurochem Res. 2016 Nov;41(11):3138-3146. Epub 2016 Aug 20. PubMed PMID: 27542961.

13: Ying H, Jiang H, Liu H, Chen F, Du Q. Ethyl acetate-n-butanol gradient solvent system for high-speed countercurrent chromatography to screen bioactive substances in okra. J Chromatogr A. 2014 Sep 12;1359:117-23. doi: 10.1016/j.chroma.2014.07.029. Epub 2014 Jul 18. PubMed PMID: 25069743.

14: Bergman JM, Wrande M, Hughes D. Acetate availability and utilization supports the growth of mutant sub-populations on aging bacterial colonies. PLoS One. 2014 Oct 2;9(10):e109255. doi: 10.1371/journal.pone.0109255. eCollection 2014. PubMed PMID: 25275605; PubMed Central PMCID: PMC4183559.

15: Dengler F, Rackwitz R, Benesch F, Pfannkuche H, Gäbel G. Bicarbonate-dependent transport of acetate and butyrate across the basolateral membrane of sheep rumen epithelium. Acta Physiol (Oxf). 2014 Feb;210(2):403-14. doi: 10.1111/apha.12155. Epub 2013 Aug 28. PubMed PMID: 23927569.

16: Zhang J, Zhang C, Qi Y, Dai L, Ma H, Guo X, Xiao D. Acetate ester production by Chinese yellow rice wine yeast overexpressing the alcohol acetyltransferase-encoding gene ATF2. Genet Mol Res. 2014 Nov 27;13(4):9735-46. doi: 10.4238/2014.November.27.1. PubMed PMID: 25501183.

17: Martynova J, Kokina A, Kibilds J, Liepins J, Scerbaka R, Vigants A. Effects of acetate on Kluyveromyces marxianus DSM 5422 growth and metabolism. Appl Microbiol Biotechnol. 2016 May;100(10):4585-94. doi: 10.1007/s00253-016-7392-0. Epub 2016 Feb 24. PubMed PMID: 26910042.

18: Amabebe E, Reynolds S, Stern V, Stafford G, Paley M, Anumba DO. Cervicovaginal Fluid Acetate: A Metabolite Marker of Preterm Birth in Symptomatic Pregnant Women. Front Med (Lausanne). 2016 Oct 10;3:48. eCollection 2016. PubMed PMID: 27777928; PubMed Central PMCID: PMC5056530.

19: Ando H, Kurata A, Kishimoto N. Antimicrobial properties and mechanism of volatile isoamyl acetate, a main flavour component of Japanese sake (Ginjo-shu). J Appl Microbiol. 2015 Apr;118(4):873-80. doi: 10.1111/jam.12764. Epub 2015 Feb 12. PubMed PMID: 25626919.

20: Unarokov ZM, Mukhoedova TV, Shuvaeva OV. Comparison of sustained low-efficiency dialysis with acetate-free and acetate-containing bicarbonate dialysate in unstable patients. Artif Organs. 2014 Oct;38(10):883-8. doi: 10.1111/aor.12251. Epub 2014 Jan 7. PubMed PMID: 24393008.