Pachymic acid
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598316

CAS#: 29070-92-6

Description: Pachymic acid is a phospholipase A2 inibitor isolated from Poria cocos.


Price and Availability

Size
Price

10mg
USD 330
Size
Price

50mg
USD 990
Size
Price

100mg
USD 1650

Pachymic acid purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 598316
Name: Pachymic acid
CAS#: 29070-92-6
Chemical Formula: C33H52O5
Exact Mass: 528.3815
Molecular Weight: 528.77
Elemental Analysis: C, 74.96; H, 9.91; O, 15.13


Synonym: Pachymic acid; CCRIS 7792;

IUPAC/Chemical Name: (R)-2-((3S,5R,10S,13R,14R,16R,17R)-3-acetoxy-16-hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-methyl-5-methyleneheptanoic acid

InChi Key: VDYCLYGKCGVBHN-DRCQUEPLSA-N

InChi Code: InChI=1S/C33H52O5/c1-19(2)20(3)10-11-22(29(36)37)28-25(35)18-33(9)24-12-13-26-30(5,6)27(38-21(4)34)15-16-31(26,7)23(24)14-17-32(28,33)8/h19,22,25-28,35H,3,10-18H2,1-2,4-9H3,(H,36,37)/t22-,25-,26+,27+,28+,31-,32-,33+/m1/s1

SMILES Code: CC1(C)[C@@H](OC(C)=O)CC[C@]2(C)C3=C([C@@]4(C[C@@H](O)[C@@H]([C@]4(CC3)C)[C@H](C(O)=O)CCC(C(C)C)=C)C)CC[C@@]12[H]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Lee YH, Lee NH, Bhattarai G, Kim GE, Lee IK, Yun BS, Hwang PH, Yi HK. Anti-inflammatory effect of pachymic acid promotes odontoblastic differentiation via HO-1 in dental pulp cells. Oral Dis. 2013 Mar;19(2):193-9. doi: 10.1111/j.1601-0825.2012.01970.x. Epub 2012 Jul 31. PubMed PMID: 22849812.

2: Cheng S, Swanson K, Eliaz I, McClintick JN, Sandusky GE, Sliva D. Pachymic acid inhibits growth and induces apoptosis of pancreatic cancer in vitro and in vivo by targeting ER stress. PLoS One. 2015 Apr 27;10(4):e0122270. doi: 10.1371/journal.pone.0122270. eCollection 2015. PubMed PMID: 25915041; PubMed Central PMCID: PMC4411097.

3: Ma J, Liu J, Lu CW, Cai DF. Pachymic acid modified carbon nanoparticles reduced angiogenesis via inhibition of MMP-3. Int J Clin Exp Pathol. 2015 May 1;8(5):5464-70. eCollection 2015. PubMed PMID: 26191251; PubMed Central PMCID: PMC4503122.

4: Chen Y, Lian P, Liu Y, Xu K. Pachymic acid inhibits tumorigenesis in gallbladder carcinoma cells. Int J Clin Exp Med. 2015 Oct 15;8(10):17781-8. eCollection 2015. PubMed PMID: 26770369; PubMed Central PMCID: PMC4694269.

5: Kim TG, Lee YH, Lee NH, Bhattarai G, Lee IK, Yun BS, Yi HK. The antioxidant property of pachymic acid improves bone disturbance against AH plus-induced inflammation in MC-3T3 E1 cells. J Endod. 2013 Apr;39(4):461-6. doi: 10.1016/j.joen.2012.11.022. Epub 2013 Jan 16. PubMed PMID: 23522537.

6: Gao AH, Zhang L, Chen X, Chen Y, Xu ZZ, Liu YN, Zhang H. Inhibition of ovarian cancer proliferation and invasion by pachymic acid. Int J Clin Exp Pathol. 2015 Feb 1;8(2):2235-41. eCollection 2015. PubMed PMID: 25973134; PubMed Central PMCID: PMC4396302.

7: Wang FY, Lv WS, Han L. Determination and Pharmacokinetic Study of Pachymic Acid by LC-MS/MS. Biol Pharm Bull. 2015;38(9):1337-44. doi: 10.1248/bpb.b15-00121. PubMed PMID: 26328488.

8: Shah VK, Choi JJ, Han JY, Lee MK, Hong JT, Oh KW. Pachymic Acid Enhances Pentobarbital-Induced Sleeping Behaviors via GABAA-ergic Systems in Mice. Biomol Ther (Seoul). 2014 Jul;22(4):314-20. doi: 10.4062/biomolther.2014.045. PubMed PMID: 25143810; PubMed Central PMCID: PMC4131518.

9: Jeong JW, Lee WS, Go SI, Nagappan A, Baek JY, Lee JD, Lee SJ, Park C, Kim GY, Kim HJ, Kim GS, Kwon TK, Ryu CH, Shin SC, Choi YH. Pachymic Acid Induces Apoptosis of EJ Bladder Cancer Cells by DR5 Up-Regulation, ROS Generation, Modulation of Bcl-2 and IAP Family Members. Phytother Res. 2015 Oct;29(10):1516-24. doi: 10.1002/ptr.5402. Epub 2015 Jul 7. PubMed PMID: 26148472.

10: Li FF, Yuan Y, Liu Y, Wu QQ, Jiao R, Yang Z, Zhou MQ, Tang QZ. Pachymic acid protects H9c2 cardiomyocytes from lipopolysaccharide-induced inflammation and apoptosis by inhibiting the extracellular signal-regulated kinase 1/2 and p38 pathways. Mol Med Rep. 2015 Aug;12(2):2807-13. doi: 10.3892/mmr.2015.3712. Epub 2015 Apr 30. PubMed PMID: 25936656.

11: Ma J, Liu J, Lu C, Cai D. Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells. Cancer Cell Int. 2015 Aug 5;15:78. doi: 10.1186/s12935-015-0230-0. eCollection 2015. PubMed PMID: 26244039; PubMed Central PMCID: PMC4524283.

12: Hong R, Shen MH, Xie XH, Ruan SM. Inhibition of breast cancer metastasis via PITPNM3 by pachymic acid. Asian Pac J Cancer Prev. 2012;13(5):1877-80. PubMed PMID: 22901140.

13: Ling H, Jia X, Zhang Y, Gapter LA, Lim YS, Agarwal R, Ng KY. Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells. Mol Carcinog. 2010 Mar;49(3):271-82. doi: 10.1002/mc.20597. PubMed PMID: 19918789.

14: Huang YC, Chang WL, Huang SF, Lin CY, Lin HC, Chang TC. Pachymic acid stimulates glucose uptake through enhanced GLUT4 expression and translocation. Eur J Pharmacol. 2010 Dec 1;648(1-3):39-49. doi: 10.1016/j.ejphar.2010.08.021. Epub 2010 Sep 9. PubMed PMID: 20816811.

15: Ling H, Zhang Y, Ng KY, Chew EH. Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression. Breast Cancer Res Treat. 2011 Apr;126(3):609-20. doi: 10.1007/s10549-010-0929-5. Epub 2010 Jun 3. PubMed PMID: 20521099.

16: Gapter L, Wang Z, Glinski J, Ng KY. Induction of apoptosis in prostate cancer cells by pachymic acid from Poria cocos. Biochem Biophys Res Commun. 2005 Jul 15;332(4):1153-61. Erratum in: Biochem Biophys Res Commun. 2006 Jan 6;339(1):457. PubMed PMID: 15913545.

17: Zheng Y, Yang XW. Absorption and transport of pachymic acid in the human intestinal cell line Caco-2 monolayers. Zhong Xi Yi Jie He Xue Bao. 2008 Jul;6(7):704-10. doi: 10.3736/jcim20080709. PubMed PMID: 18601852.

18: Giner EM, Máñez S, Recio MC, Giner RM, Cerdá-Nicolás M, Ríos JL. In vivo studies on the anti-inflammatory activity of pachymic and dehydrotumulosic acids. Planta Med. 2000 Apr;66(3):221-7. PubMed PMID: 10821046.

19: Zhang F, Zhang XF, Wang BC, Liu HY, Li CY, Liu ZH, Zhang GW, Lü H, Chi C, Wang F. Pachymic acid, a novel compound for anti-rejection: effect in rats following cardiac allograft transplantation. Chin Med J (Engl). 2009 Dec 5;122(23):2898-902. PubMed PMID: 20092798.

20: Kitagawa H, Munekage M, Matsumoto T, Sadakane C, Fukutake M, Aoki K, Watanabe J, Maemura K, Hattori T, Kase Y, Uezono Y, Inui A, Hanazaki K. Pharmacokinetic Profiles of Active Ingredients and Its Metabolites Derived from Rikkunshito, a Ghrelin Enhancer, in Healthy Japanese Volunteers: A Cross-Over, Randomized Study. PLoS One. 2015 Jul 17;10(7):e0133159. doi: 10.1371/journal.pone.0133159. eCollection 2015. PubMed PMID: 26186592; PubMed Central PMCID: PMC4506051.