UNC0224
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555287

CAS#: 1197196-48-7

Description: NC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM.4 Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM.


Chemical Structure

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UNC0224
CAS# 1197196-48-7

Theoretical Analysis

MedKoo Cat#: 555287
Name: UNC0224
CAS#: 1197196-48-7
Chemical Formula: C26H43N7O2
Exact Mass: 485.3478
Molecular Weight: 485.677
Elemental Analysis: C, 64.30; H, 8.92; N, 20.19; O, 6.59

Price and Availability

Size Price Availability Quantity
10.0mg USD 365.0 2 Weeks
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Synonym: UNC0224; UNC-0224; UNC 0224;

IUPAC/Chemical Name: 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine

InChi Key: XIVUGRBSBIXXJE-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H43N7O2/c1-30(2)10-7-17-35-24-19-22-21(18-23(24)34-5)25(27-20-8-13-32(4)14-9-20)29-26(28-22)33-12-6-11-31(3)15-16-33/h18-20H,6-17H2,1-5H3,(H,27,28,29)

SMILES Code: CN1CCC(NC2=C3C=C(OC)C(OCCCN(C)C)=CC3=NC(N4CCN(C)CCC4)=N2)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 485.677 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu F, Chen X, Allali-Hassani A, Quinn AM, Wigle TJ, Wasney GA, Dong A,
Senisterra G, Chau I, Siarheyeva A, Norris JL, Kireev DB, Jadhav A, Herold JM,
Janzen WP, Arrowsmith CH, Frye SV, Brown PJ, Simeonov A, Vedadi M, Jin J. Protein
lysine methyltransferase G9a inhibitors: design, synthesis, and structure
activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem.
2010 Aug 12;53(15):5844-57. doi: 10.1021/jm100478y. PubMed PMID: 20614940; PubMed
Central PMCID: PMC2920043.

2: Liu F, Chen X, Allali-Hassani A, Quinn AM, Wasney GA, Dong A, Barsyte D,
Kozieradzki I, Senisterra G, Chau I, Siarheyeva A, Kireev DB, Jadhav A, Herold
JM, Frye SV, Arrowsmith CH, Brown PJ, Simeonov A, Vedadi M, Jin J. Discovery of a
2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of
histone lysine methyltransferase G9a. J Med Chem. 2009 Dec 24;52(24):7950-3. doi:
10.1021/jm901543m. PubMed PMID: 19891491; PubMed Central PMCID: PMC2825141.

UNC0224

10.0mg / USD 365.0