Zilpaterol hydrochloride
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461120

CAS#: 119520-06-8

Description: Zilpaterol hydrochloride isa β-adrenergic receptor (AR) agonist. It is used to increase the size of cattle and the efficiency of feeding them.


Chemical Structure

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Zilpaterol hydrochloride
CAS# 119520-06-8

Theoretical Analysis

MedKoo Cat#: 461120
Name: Zilpaterol hydrochloride
CAS#: 119520-06-8
Chemical Formula: C14H20ClN3O2
Exact Mass: 297.1244
Molecular Weight: 297.78
Elemental Analysis: C, 56.47; H, 6.77; Cl, 11.90; N, 14.11; O, 10.75

Price and Availability

Size Price Availability Quantity
10.0mg USD 880.0 2 Weeks
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Synonym: Zilpaterol hydrochloride;

IUPAC/Chemical Name: 6-hydroxy-7-(isopropylamino)-6,7,8,9-tetrahydro-2,9a-diazabenzo[cd]azulen-1(2H)-one hydrochloride

InChi Key: GIEFXLLRTJNFGT-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19N3O2.ClH/c1-8(2)15-11-6-7-17-12-9(13(11)18)4-3-5-10(12)16-14(17)19;/h3-5,8,11,13,15,18H,6-7H2,1-2H3,(H,16,19);1H

SMILES Code: O=C1NC2=C(N1CCC(NC(C)C)C3O)C3=CC=C2.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 297.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Frese DA, Reinhardt CD, Bartle SJ, Rethorst DN, Bawa B, Thomason JD, Loneragan GH, Thomson DU. Effect of ractopamine hydrochloride and zilpaterol hydrochloride on cardiac electrophysiologic and hematologic variables in finishing steers. J Am Vet Med Assoc. 2016 Sep 15;249(6):668-77. doi: 10.2460/javma.249.6.668. PubMed PMID: 27585105.

2: Brown TR, Sexten AK, Lawrence TE, Miller MF, Thomas CL, Yates DA, Hutcheson JP, Hodgen JM, Brooks JC. Comparative effects of zilpaterol hydrochloride and ractopamine hydrochloride on live performance and carcass characteristics of calf-fed Holstein steers. J Anim Sci. 2014 Sep;92(9):4217-22. doi: 10.2527/jas.2014-7754. Epub 2014 Jul 8. PubMed PMID: 25006068.

3: Van Bibber-Krueger CL, Miller KA, Parsons GL, Thompson LK, Drouillard JS. Effects of zilpaterol hydrochloride on growth performance, blood metabolites, and fatty acid profiles of plasma and adipose tissue in finishing steers. J Anim Sci. 2015 May;93(5):2419-27. doi: 10.2527/jas.2014-8771. PubMed PMID: 26020337.

4: Macías-Cruz U, Álvarez-Valenzuela FD, Soto-Navarro SA, Aguila-Tepato E, Avendaño-Reyes L. Effect of zilpaterol hydrochloride on feedlot performance, nutrient intake, and digestibility in hair-breed sheep. J Anim Sci. 2013 Apr;91(4):1844-9. doi: 10.2527/jas.2011-4911. Epub 2013 Jan 23. PubMed PMID: 23345549.

5: Parr SL, Brown TR, Ribeiro FR, Chung KY, Hutcheson JP, Blackwell BR, Smith PN, Johnson BJ. Biological responses of beef steers to steroidal implants and zilpaterol hydrochloride. J Anim Sci. 2014 Aug;92(8):3348-63. doi: 10.2527/jas.2013-7221. Epub 2014 Jul 1. PubMed PMID: 24987078.

6: Miller EK, Chung KY, Hutcheson JP, Yates DA, Smith SB, Johnson BJ. Zilpaterol hydrochloride alters abundance of β-adrenergic receptors in bovine muscle cells but has little effect on de novo fatty acid biosynthesis in bovine subcutaneous adipose tissue explants. J Anim Sci. 2012 Apr;90(4):1317-27. doi: 10.2527/jas.2011-4589. Epub 2011 Nov 11. PubMed PMID: 22079997.

7: Garmyn AJ, Brooks JC, Hodgen JM, Nichols WT, Hutcheson JP, Rathmann RJ, Miller MF. Comparative effects of supplementing beef steers with zilpaterol hydrochloride, ractopamine hydrochloride, or no beta agonist on strip loin composition, raw and cooked color properties, shear force, and consumer assessment of steaks aged for fourteen or twenty-one days postmortem. J Anim Sci. 2014 Aug;92(8):3670-84. doi: 10.2527/jas.2014-7840. Epub 2014 May 30. PubMed PMID: 24879757.

8: Van Bibber-Krueger CL, Miller KA, Drouillard JS. Manipulation of dietary calcium concentration to potentiate changes in tenderness of beef from heifers supplemented with zilpaterol hydrochloride. J Anim Sci. 2015 Apr;93(4):1962-6. doi: 10.2527/jas.2014-8749. PubMed PMID: 26020219.

9: Loneragan GH, Thomson DU, Scott HM. Increased mortality in groups of cattle administered the β-adrenergic agonists ractopamine hydrochloride and zilpaterol hydrochloride. PLoS One. 2014 Mar 12;9(3):e91177. doi: 10.1371/journal.pone.0091177. eCollection 2014. PubMed PMID: 24621596; PubMed Central PMCID: PMC3951294.

10: Hosford AD, Hergenreder JE, Kim JK, Baggerman JO, Ribeiro FR, Anderson MJ, Spivey KS, Rounds W, Johnson BJ. Effects of supplemental lysine and methionine with zilpaterol hydrochloride on feedlot performance, carcass merit, and skeletal muscle fiber characteristics in finishing feedlot cattle. J Anim Sci. 2015 Sep;93(9):4532-44. doi: 10.2527/jas.2015-9047. PubMed PMID: 26440352.

11: Rodas-González A, Pflanzer SB, Garmyn AJ, Martin JN, Brooks JC, Knobel SM, Johnson BJ, Starkey JD, Rathmann RJ, de Felicio PE, Streeter MN, Yates DA, Hodgen JM, Hutcheson JP, Miller MF. Effects of postmortem calcium chloride injection on meat palatability traits of strip loin steaks from cattle supplemented with or without zilpaterol hydrochloride. J Anim Sci. 2012 Oct;90(10):3584-95. doi: 10.2527/jas.2012-5159. Epub 2012 Jul 31. PubMed PMID: 22851240.

12: Korn KT, Lemenager RP, Claeys MC, Engstrom M, Schoonmaker JP. Supplemental vitamin D3 and zilpaterol hydrochloride. I. Effect on performance, carcass traits, tenderness, and vitamin D metabolites of feedlot steers. J Anim Sci. 2013 Jul;91(7):3322-31. doi: 10.2527/jas.2012-5960. PubMed PMID: 23798522.

13: Howard ST, Woerner DR, Vote DJ, Scanga JA, Chapman PL, Bryant TC, Acheson RJ, Tatum JD, Belk KE. Effects of ractopamine hydrochloride and zilpaterol hydrochloride supplementation on longissimus muscle shear force and sensory attributes of calf-fed Holstein steers. J Anim Sci. 2014 Jan;92(1):376-83. doi: 10.2527/jas.2013-7041. Epub 2013 Nov 15. PubMed PMID: 24243905.

14: Reinhardt CD, Vahl CI, Depenbusch BE, Hutcheson JP, Thomson DU. Feeding zilpaterol hydrochloride is associated with decreased dry matter intake shortly after initiation of feeding dependent on season and previous intake. J Anim Sci. 2014 Oct;92(10):4751-60. doi: 10.2527/jas.2014-7562. Epub 2014 Sep 2. PubMed PMID: 25184840.

15: Cônsolo NRB, Ferrari VB, Mesquita LG, Goulart RS, Silva LFPE. Zilpaterol hydrochloride improves beef yield, changes palatability traits, and increases calpain-calpastatin gene expression in Nellore heifers. Meat Sci. 2016 Nov;121:375-381. doi: 10.1016/j.meatsci.2016.07.005. Epub 2016 Jul 11. PubMed PMID: 27427783.

16: Cônsolo NR, Rodriguez FD, Goulart RS, Frasseto MO, Ferrari VB, Silva LF. Zilpaterol hydrochloride improves feed efficiency and changes body composition in nonimplanted Nellore heifers. J Anim Sci. 2015 Oct;93(10):4948-55. doi: 10.2527/jas.2015-9291. PubMed PMID: 26523587.

17: Dávila-Ramírez JL, Macías-Cruz U, Torrentera-Olivera NG, González-Ríos H, Soto-Navarro SA, Rojo-Rubio R, Avendaño-Reyes L. Effects of zilpaterol hydrochloride and soybean oil supplementation on feedlot performance and carcass characteristics of hair-breed ram lambs under heat stress conditions. J Anim Sci. 2014 Mar;92(3):1184-92. doi: 10.2527/jas.2012-6214. Epub 2014 Feb 4. PubMed PMID: 24496845.

18: Hales KE, Foote AP, Jones SA, Shackelford SD, Boyd BM, Erickson GE. The effects of zilpaterol hydrochloride and shade on blood metabolites of finishing beef steers. J Anim Sci. 2016 Jul;94(7):2937-41. doi: 10.2527/jas.2015-9967. PubMed PMID: 27482680.

19: McEvers TJ, Nichols WT, Hutcheson JP, Edmonds MD, Lawrence TE. Feeding performance, carcass characteristics, and tenderness attributes of steers sorted by the Igenity tenderness panel and fed zilpaterol hydrochloride. J Anim Sci. 2012 Nov;90(11):4140-7. doi: 10.2527/jas.2012-5120. Epub 2012 Aug 2. PubMed PMID: 22859750.

20: McEvers TJ, Walter LJ, Defoor PJ, Swingle RS, Hutcheson JP, Lawrence TE. The effect of supplementing zilpaterol hydrochloride on feeding performance and carcass characteristics of steers sorted by leptin genotype. J Anim Sci. 2014 Jan;92(1):332-8. doi: 10.2527/jas.2013-6736. Epub 2013 Dec 4. PubMed PMID: 24305868.