WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558464

CAS#: 1701-69-5

Description: 1-(4-Pyridinyl)-1-propanone is chemical for drug synthesis

Chemical Structure

CAS# 1701-69-5

Theoretical Analysis

MedKoo Cat#: 558464
Name: 1-(4-Pyridinyl)-1-propanone
CAS#: 1701-69-5
Chemical Formula: C8H9NO
Exact Mass: 135.07
Molecular Weight: 135.17
Elemental Analysis: C, 71.09; H, 6.71; N, 10.36; O, 11.84

Price and Availability

Size Price Availability Quantity
1.0g USD 250.0 2 Weeks
5.0g USD 750.0 2 Weeks
10.0g USD 1250.0 2 Weeks
Bulk inquiry

Synonym: 1-(4-Pyridinyl)-1-propanone; 1-4-Pyridinyl-1-propanone; 1(4Pyridinyl)1propanone; Ketone, ethyl 4-pyridyl; Pyridine, 4-propionyl-;

IUPAC/Chemical Name: 1-Propanone, 1-(4-pyridinyl)- (9CI)


InChi Code: InChI=1S/C8H9NO/c1-2-8(10)7-3-5-9-6-4-7/h3-6H,2H2,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 135.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Kurumurthy C, Veeraswamy B, Sambasiva Rao P, Santhosh Kumar G, Shanthan Rao P, Loka Reddy V, Venkateswara Rao J, Narsaiah B. Synthesis of novel 1,2,3-triazole tagged pyrazolo[3,4-b]pyridine derivatives and their cytotoxic activity. Bioorg Med Chem Lett. 2014 Feb 1;24(3):746-9. doi: 10.1016/j.bmcl.2013.12.107. Epub 2014 Jan 3. PubMed PMID: 24424132.

2: Nowicka A, Liszkiewicz H, Nawrocka WP, Wietrzyk J, Zubiak A, Kołodziejczyk W. Synthesis and antiproliferative activity in vitro of new 2-thioxoimidazo[4,5-B]pyridine derivatives. Acta Pol Pharm. 2015 Jan-Feb;72(1):101-11. PubMed PMID: 25850205.

3: Riaz S, Khan IU, Yar M, Ashraf M, Rehman TU, Shaukat A, Jamal SB, Duarte VC, Alves MJ. Novel pyridine-2,4,6-tricarbohydrazide derivatives: design, synthesis, characterization and in vitro biological evaluation as α- and β-glucosidase inhibitors. Bioorg Chem. 2014 Dec;57:148-54. doi: 10.1016/j.bioorg.2014.10.007. Epub 2014 Nov 6. PubMed PMID: 25462991.

4: Sharath Kumar KS, Hanumappa A, Hegde M, Narasimhamurthy KH, Raghavan SC, Rangappa KS. Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells. Eur J Med Chem. 2014 Jun 23;81:341-9. doi: 10.1016/j.ejmech.2014.05.009. Epub 2014 May 4. PubMed PMID: 24852281.

5: Liu H, Li FX, Pi Y, Wang DJ, Hu YJ, Zheng J. Fluorescence quenching study of 2,6-bis(5-(4-methylphenyl)-1-H-pyrazol-3-yl)pyridine with metal ions. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jun 15;145:588-593. doi: 10.1016/j.saa.2015.03.049. Epub 2015 Mar 9. PubMed PMID: 25818306.

6: Adhami F, Safavi M, Ehsani M, Ardestani SK, Emmerling F, Simyari F. Synthesis, crystal structure, and cytotoxic activity of novel cyclic systems in [1,2,4]thiadiazolo[2,3-a]pyridine benzamide derivatives and their copper(II) complexes. Dalton Trans. 2014 Jun 7;43(21):7945-57. doi: 10.1039/c3dt52905c. Epub 2014 Apr 9. PubMed PMID: 24715093.

7: Lach F, Koza P. Practical way to imidazo[4,5-b] and [4,5-c]pyridine-2-ones via cascade ureidation/palladium-catalyzed cyclization. ACS Comb Sci. 2012 Sep 10;14(9):491-5. doi: 10.1021/co300078f. Epub 2012 Aug 10. PubMed PMID: 22873837.

8: Jun KY, Kwon H, Park SE, Lee E, Karki R, Thapa P, Lee JH, Lee ES, Kwon Y. Discovery of dihydroxylated 2,4-diphenyl-6-thiophen-2-yl-pyridine as a non-intercalative DNA-binding topoisomerase II-specific catalytic inhibitor. Eur J Med Chem. 2014 Jun 10;80:428-38. doi: 10.1016/j.ejmech.2014.04.066. Epub 2014 Apr 24. PubMed PMID: 24796883.

9: Zhang Y, Chang L, Yan N, Tang Y, Liu R, Rittmann BE. UV photolysis for accelerating pyridine biodegradation. Environ Sci Technol. 2014;48(1):649-55. doi: 10.1021/es404399t. Epub 2013 Dec 23. PubMed PMID: 24364496.

10: Sun GX, Yang MY, Shi YX, Sun ZH, Liu XH, Wu HK, Li BJ, Zhang YG. Microwave assistant synthesis, antifungal activity and DFT theoretical study of some novel 1,2,4-triazole derivatives containing pyridine moiety. Int J Mol Sci. 2014 May 8;15(5):8075-90. doi: 10.3390/ijms15058075. PubMed PMID: 24815069; PubMed Central PMCID: PMC4057720.

11: Krzyżak E, Śliwińska M, Malinka W. Synthesis and fluorescence properties of new ester derivatives of isothiazolo [4,5-b] pyridine. J Fluoresc. 2015 Mar;25(2):277-82. doi: 10.1007/s10895-015-1504-6. Epub 2015 Jan 23. PubMed PMID: 25612854; PubMed Central PMCID: PMC4361752.

12: Doshi H, Thakkar S, Khirsariya P, Thakur MC, Ray A. 6-Tosyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide analogues: synthesis, characterization, MO calculation, and antibacterial activity. Appl Biochem Biotechnol. 2015 Feb;175(3):1700-9. doi: 10.1007/s12010-014-1399-8. Epub 2014 Nov 26. PubMed PMID: 25422060.

13: Bourget P, Amin A, Dupont C, Abely M, Desmazes-Dufeu N, Dubus JC, Jouani BL, Merlette C, Nové-Josserand R, Pages J, Panzo R, Vidal F, Voge F, Hubert D. How to minimize toxic exposure to pyridine during continuous infusion of ceftazidime in patients with cystic fibrosis? Antimicrob Agents Chemother. 2014 May;58(5):2849-55. doi: 10.1128/AAC.02637-13. Epub 2014 Mar 10. PubMed PMID: 24614367; PubMed Central PMCID: PMC3993216.

14: Bakhite EA, Abd-Ella AA, El-Sayed ME, Abdel-Raheem SA. Pyridine derivatives as insecticides. Part 1: synthesis and toxicity of some pyridine derivatives against cowpea aphid, Aphis craccivora Koch (Homoptera: Aphididae). J Agric Food Chem. 2014 Oct 15;62(41):9982-6. doi: 10.1021/jf503992y. Epub 2014 Oct 2. PubMed PMID: 25226271.

15: Khojasteh SC, Yue Q, Ma S, Castanedo G, Chen JZ, Lyssikatos J, Mulder T, Takahashi R, Ly J, Messick K, Jia W, Liu L, Hop CE, Wong H. Investigations into the mechanisms of pyridine ring cleavage in vismodegib. Drug Metab Dispos. 2014 Mar;42(3):343-51. doi: 10.1124/dmd.113.055715. Epub 2014 Jan 3. PubMed PMID: 24389420.

16: Tang Y, Zhang Y, Yan N, Liu R, Rittmann BE. The role of electron donors generated from UV photolysis for accelerating pyridine biodegradation. Biotechnol Bioeng. 2015 Sep;112(9):1792-800. doi: 10.1002/bit.25605. Epub 2015 Jun 30. PubMed PMID: 25854706.

17: Pham TH, Hovhannisyan A, Bouvier D, Tian L, Reboud-Ravaux M, Melikyan G, Bouvier-Durand M. A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3822-7. doi: 10.1016/j.bmcl.2012.03.105. Epub 2012 Apr 13. PubMed PMID: 22560566.

18: Wakabayashi S, Kuse M, Kida A, Komeda S, Tatsumi K, Sugihara Y. The structure of 3-(diethylborylethynyl)pyridine: a nonplanarly arranged cyclic trimer. Org Biomol Chem. 2014 Aug 7;12(29):5382-7. doi: 10.1039/c4ob00849a. PubMed PMID: 24927393.

19: Usuki T, Sugimura T, Komatsu A, Koseki Y. Biomimetic Chichibabin pyridine synthesis of the COPD biomarkers and elastin cross-linkers isodesmosine and desmosine. Org Lett. 2014 Mar 21;16(6):1672-5. doi: 10.1021/ol500333t. Epub 2014 Mar 5. PubMed PMID: 24597689.

20: Arjomandi-Behzad L, Yamini Y, Rezazadeh M. Extraction of pyridine derivatives from human urine using electromembrane extraction coupled to dispersive liquid-liquid microextraction followed by gas chromatography determination. Talanta. 2014 Aug;126:73-81. doi: 10.1016/j.talanta.2014.02.066. Epub 2014 Mar 24. PubMed PMID: 24881536.