Carbetamide | CAS#16118-49-3 | mitosis inhibitor

Carbetamide
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598207

CAS#: 16118-49-3

Description: Carbetamide is a mitosis inhibitor.

Chemical Structure

Carbetamide

CAS# 16118-49-3

Instruction

Theoretical Analysis

MedKoo Cat#: 598207
Name: Carbetamide
CAS#: 16118-49-3
Chemical Formula: C12H16N2O3
Exact Mass: 236.12
Molecular Weight: 236.270
Elemental Analysis: C, 61.00; H, 6.83; N, 11.86; O, 20.31

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 300	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Carbetamide; EPA Pesticide Chemical Code 259200; 11,561 RP; Caswell No. 159B;

IUPAC/Chemical Name: (R)-1-(ethylamino)-1-oxopropan-2-yl phenylcarbamate

InChi Key: AMRQXHFXNZFDCH-SECBINFHSA-N

InChi Code: InChI=1S/C12H16N2O3/c1-3-13-11(15)9(2)17-12(16)14-10-7-5-4-6-8-10/h4-9H,3H2,1-2H3,(H,13,15)(H,14,16)/t9-/m1/s1

SMILES Code: C[C@@H](OC(NC1=CC=CC=C1)=O)C(NCC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 236.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Crovetto G, Navalón A, Ballesteros O, Vílchez JL, García-Herruzo F, Rodríguez-Maroto JM. Mobility and fate of carbetamide in an agricultural soil. J Environ Sci Health B. 2009 Nov;44(8):764-71. doi: 10.1080/03601230903238301. PubMed PMID: 20183088.

2: Lagator M, Vogwill T, Colegrave N, Neve P. Herbicide cycling has diverse effects on evolution of resistance in Chlamydomonas reinhardtii. Evol Appl. 2013 Feb;6(2):197-206. doi: 10.1111/j.1752-4571.2012.00276.x. Epub 2012 Jun 11. PubMed PMID: 23467494; PubMed Central PMCID: PMC3586617.

3: Guardigli A, Chow W, Lefar MS. Determination of carbetamide residues and its aniline metabolite. J Agric Food Chem. 1972 Mar-Apr;20(2):348-50. PubMed PMID: 5016617.

4: Tediosi A, Whelan MJ, Rushton KR, Thompson TR, Gandolfi C, Pullan SP. Measurement and conceptual modelling of herbicide transport to field drains in a heavy clay soil with implications for catchment-scale water quality management. Sci Total Environ. 2012 Nov 1;438:103-12. doi: 10.1016/j.scitotenv.2012.08.042. Epub 2012 Sep 11. PubMed PMID: 22982449.

5: Lagator M, Colegrave N, Neve P. Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses. Proc Biol Sci. 2014 Nov 7;281(1794):20141679. doi: 10.1098/rspb.2014.1679. PubMed PMID: 25232137; PubMed Central PMCID: PMC4211454.

6: Lagator M, Vogwill T, Mead A, Colegrave N, Neve P. Herbicide mixtures at high doses slow the evolution of resistance in experimentally evolving populations of Chlamydomonas reinhardtii. New Phytol. 2013 May;198(3):938-45. doi: 10.1111/nph.12195. Epub 2013 Feb 25. PubMed PMID: 23432427.

7: Hidalgo C, Sancho JV, López FJ, Hernández F. Automated determination of phenylcarbamate herbicides in environmental waters by on-line trace enrichment and reversed-phase liquid chromatography-diode array detection. J Chromatogr A. 1998 Oct 9;823(1-2):121-8. PubMed PMID: 9818399.

8: Carabias-Martínez R, García-Hermida C, Rodríguez-Gonzalo E, Ruano-Miguel L. Behaviour of carbamate pesticides in gas chromatography and their determination with solid-phase extraction and solid-phase microextraction as preconcentration steps. J Sep Sci. 2005 Nov;28(16):2130-8. PubMed PMID: 16318209.

9: Tediosi A, Whelan MJ, Rushton KR, Gandolfi C. Predicting rapid herbicide leaching to surface waters from an artificially drained headwater catchment using a one dimensional two-domain model coupled with a simple groundwater model. J Contam Hydrol. 2013 Feb;145:67-81. doi: 10.1016/j.jconhyd.2012.12.003. Epub 2012 Dec 20. PubMed PMID: 23313906.

10: Rodríguez-Gonzalo E, Ruano-Miguel L, Carabias-Martínez R. In-capillary microextraction using monolithic polymers: application to preconcentration of carbamate pesticides prior to their separation by MEKC. Electrophoresis. 2009 Jun;30(11):1913-22. doi: 10.1002/elps.200800699. PubMed PMID: 19517433.

11: Panzera F, Giménez-Abián MI, López-Sáez JF, Giménez-Martín G, Cuadrado A, Cánovas JL, De la Torre C. Competence for nuclear replication and the NOR-chromosomes of Allium cepa L. Eur J Cell Biol. 1997 Jan;72(1):9-12. PubMed PMID: 9013720.

12: Giménez-Martín G, Panzera F, Cánovas JL, de la Torre C, López-Sáez JF. A limited number of chromosomes makes a nucleus competent to respond to inducers of replication and mitosis in a plant. Eur J Cell Biol. 1992 Jun;58(1):163-71. PubMed PMID: 1644061.

13: Geerdink RB, Kooistra-Sijpersma A, Tiesnitsch J, Kienhuis PG, Brinkman UA. Determination of polar pesticides with atmospheric pressure chemical ionisation mass spectrometry-mass spectrometry using methanol and/or acetonitrile for solid-phase desorption and gradient liquid chromatography. J Chromatogr A. 1999 Nov 26;863(2):147-55. PubMed PMID: 10593495.

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