Benoxinate HCl
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MedKoo CAT#: 598205

CAS#: 5987-82-6

Description: Benoxinate HCl is a local anesthetic used in ophthalmology to numb the surface of the eye for a variety of procedures.


Price and Availability

Size Price Shipping out time Quantity
1g USD 290 2 weeks
5g USD 440 2 weeks
50g USD 1650 2 weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-15. Prices are subject to change without notice.

Benoxinate HCl purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 598205
Name: Benoxinate HCl
CAS#: 5987-82-6
Chemical Formula: C17H29ClN2O3
Exact Mass:
Molecular Weight: 344.88
Elemental Analysis: C, 59.21; H, 8.48; Cl, 10.28; N, 8.12; O, 13.92


Synonym: Benoxinate hydrochloride; Benoxinate HCl; Lacrimin; Novesin; Minims Benoxinate; Oxbarukain;

IUPAC/Chemical Name: 2-(diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride

InChi Key: PRGUDWLMFLCODA-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H28N2O3.ClH/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3;/h8-9,13H,4-7,10-12,18H2,1-3H3;1H

SMILES Code: O=C(OCCN(CC)CC)C1=CC=C(N)C(OCCCC)=C1.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Bentley CR, Larke JR. Apparent respiration rate of the human corneal epithelium with tetracaine HCl and benoxinate HCl. Am J Optom Physiol Opt. 1983 Dec;60(12):960-3. PubMed PMID: 6660279.

2: El-Gindy A. First derivative spectrophotometric and LC determination of benoxinate hydrochloride and its degradation products. J Pharm Biomed Anal. 2000 Mar;22(2):215-34. PubMed PMID: 10719904.

3: Carney LG, O'Leary DJ, Millodot M. Effect of topical anaesthesia on corneal epithelial fragility. Int Ophthalmol. 1984 Jun;7(2):71-3. PubMed PMID: 6480223.

4: Kleinfeld J, Ellis PP. Inhibition of microorganisms by topical anesthetics. Appl Microbiol. 1967 Nov;15(6):1296-8. PubMed PMID: 16349737; PubMed Central PMCID: PMC547186.

5: Almubrad TM, Alshehri FH, Ogbuehi KC, Osuagwu UL. Comparison of the influence of nonpreserved oxybuprocaine and a preserved artificial tear (thera tears) on human corneal thickness measured by two pachymeters. J Ocul Pharmacol Ther. 2013 Jun;29(5):462-8. doi: 10.1089/jop.2012.0215. Epub 2013 Jan 18. PubMed PMID: 23331053.

6: Ogbuehi KC, Chijuka JC, Osuagwu UL. Changes in central corneal thickness values after instillation of oxybuprocaine hydrochloride 0.4%. Cont Lens Anterior Eye. 2012 Oct;35(5):199-202. doi: 10.1016/j.clae.2012.05.004. Epub 2012 Jun 15. PubMed PMID: 22704944.

7: Alani SD. The ophthalmic rod: a new ophthalmic drug delivery system I. Graefes Arch Clin Exp Ophthalmol. 1990;228(4):297-301. PubMed PMID: 2205544.

8: Lipshitz I, Loewenstein A, Lazar M. [Excimer laser correction of myopia]. Harefuah. 1993 Jul;125(1-2):4-6, 64. Hebrew. PubMed PMID: 8225068.