WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555285

CAS#: 2036082-79-6

Description: JNJ-56022486 is an AMPA receptor modulator which is selective for TARP γ‑8.

Chemical Structure

CAS# 2036082-79-6

Theoretical Analysis

MedKoo Cat#: 555285
Name: JNJ-56022486
CAS#: 2036082-79-6
Chemical Formula: C15H10ClN3O
Exact Mass: 283.0512
Molecular Weight: 283.72
Elemental Analysis: C, 63.50; H, 3.55; Cl, 12.49; N, 14.81; O, 5.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JNJ-56022486; JNJ 56022486; JNJ56022486.

IUPAC/Chemical Name: 2-(3-chloro-2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)phenyl)acetonitrile


InChi Code: InChI=1S/C15H10ClN3O/c16-11-3-1-2-9(6-7-17)14(11)10-4-5-12-13(8-10)19-15(20)18-12/h1-5,8H,6H2,(H2,18,19,20)

SMILES Code: N#CCC1=CC=CC(Cl)=C1C2=CC=C(C(N3)=C2)NC3=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 283.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Maher MP, Ameriks MK, Savall BM, Carruthers NI, Lovenberg TW. Reply to "A Comment on 'Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8'". J Pharmacol Exp Ther. 2016 Sep;358(3):527. doi: 10.1124/jpet.116.234815. PubMed PMID: 27528545.

2: Witkin JM, Gardinier KM. A Comment on "Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8". J Pharmacol Exp Ther. 2016 Sep;358(3):502-3. doi: 10.1124/jpet.116.234419. PubMed PMID: 27528544.

3: Maher MP, Wu N, Ravula S, Ameriks MK, Savall BM, Liu C, Lord B, Wyatt RM, Matta JA, Dugovic C, Yun S, Ver Donck L, Steckler T, Wickenden AD, Carruthers NI, Lovenberg TW. Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8. J Pharmacol Exp Ther. 2016 May;357(2):394-414. doi: 10.1124/jpet.115.231712. Epub 2016 Mar 17. PubMed PMID: 26989142.