Papaveraldine

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MedKoo CAT#: 558453

CAS#: 522-57-6

Description: Papaveraldine is a degradation product of papaverine and known benzylisoquinoline alkaloid.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

Papaveraldine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 558453
Name: Papaveraldine
CAS#: 522-57-6
Chemical Formula: C20H19NO5
Exact Mass: 353.13
Molecular Weight: 353.37
Elemental Analysis: C, 67.98; H, 5.42; N, 3.96; O, 22.64


Synonym: Papaveraldine; Papaveraldine; Xanthaline;

IUPAC/Chemical Name: (6,7-Dimethoxy-1-isoquinolyl) (3,4-dimethoxyphenyl) ketone

InChi Key: QJTBIAMBPGGIGI-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19NO5/c1-23-15-6-5-13(10-16(15)24-2)20(22)19-14-11-18(26-4)17(25-3)9-12(14)7-8-21-19/h5-11H,1-4H3

SMILES Code: O=C(C1=NC=CC2=C1C=C(OC)C(OC)=C2)C3=CC=C(OC)C(OC)=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Piotrowska K, Hermann TW, Augustyniak W. Photooxidation of papaverine, papaverinol and papaveraldine in their chloroform solutions. Acta Pol Pharm. 2002 Sep-Oct;59(5):359-64. PubMed PMID: 12602797.

2: Colautti A, Fontani F, Maurich V. HPLC determination of papaveraldine and papaverinol in papaverine injection. J Pharm Biomed Anal. 1987;5(5):493-9. PubMed PMID: 16867493.

3: MACHOVICOVA F, PARRAK V. [Paper chromatographic separation of papaverine, papaverinol & papaveraldine]. Pharmazie. 1959 Jan;14(1):10-2. German. PubMed PMID: 13657671.

4: KREPINSKY J. [Spectrophotometric and colorimetric determination of papverinol and papaveraldine in papaverine]. Cesk Farm. 1962 May 5;11:205-10. Czech. PubMed PMID: 14459579.

5: MERCIER F, MERCIER J, SESTIER MR. [Experimental spasmolytic action of papaverinol and papaveraldine, secondary alkaloids prepared during papaverine synthesis]. C R Seances Soc Biol Fil. 1951 Mar;145(5-6):408-10. Undetermined Language. PubMed PMID: 14849079.

6: El Sayed KA. Microbial transformation of papaveraldine. Phytochemistry. 2000 Mar;53(6):675-8. PubMed PMID: 10746880.

7: Postaire E, Oulare B, Pradeau D, Hamon M. [Simultaneous assay of papaverine and papaveraldine. Applications to the control of pharmaceutical preparations and kinetic study of oxidation reactions]. Ann Pharm Fr. 1985;43(6):547-56. French. PubMed PMID: 3838030.

8: Maurich V, Moneghini M. [HPLC separation of papaverine hydrochloride and its degradation products papaveraldine and papaverinol. Quantitative determination in vials and granules]. Boll Chim Farm. 1983 Jul;122(7):322-9. Italian. PubMed PMID: 6651970.

9: Habashy GM, Farid NA. Thin-layer chromatographic method for separation and determination of papaverine and its oxidation products. Talanta. 1973 Jul;20(7):699-702. PubMed PMID: 18961335.

10: Anselmi E, Fayos G, Blasco R, Candenas L, Cortes D, D'Ocon P. Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle. J Pharm Pharmacol. 1992 Apr;44(4):337-43. PubMed PMID: 1355547.

11: Piotrowska K, Hermann TW, Augustyniak W. Kinetics of photooxidation of papaverine hydrochloride and its major photooxidation products. J Pharm Biomed Anal. 2006 Jun 16;41(4):1391-5. Epub 2006 Mar 31. PubMed PMID: 16580169.

12: Pingaew R, Prachayasittikul S, Ruchirawat S. Synthesis, cytotoxic and antimalarial activities of benzoyl thiosemicarbazone analogs of isoquinoline and related compounds. Molecules. 2010 Feb 23;15(2):988-96. doi: 10.3390/molecules15020988. PubMed PMID: 20335957.

13: Girreser U, Hermann TW, Piotrowska K. Oxidation and degradation products of papaverine. Part II[1]: investigations on the photochemical degradation of papaverine solutions. Arch Pharm (Weinheim). 2003 Sep;336(9):401-5. PubMed PMID: 14528487.

14: Pohloudek-Fabini R, Gundermann P. [Contribution to the stability of papaverine. Part 2: Quantitative determination of papaverine in the presence of degradation products (author's transl)]. Pharmazie. 1979;34(2):75-6. German. PubMed PMID: 441109.