GW779439X
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558446

CAS#: 551919-98-3

Description: GW779439X is a cyclin dependent kinase inhibitor.


Chemical Structure

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GW779439X
CAS# 551919-98-3

Theoretical Analysis

MedKoo Cat#: 558446
Name: GW779439X
CAS#: 551919-98-3
Chemical Formula: C22H21F3N8
Exact Mass: 454.18
Molecular Weight: 454.461
Elemental Analysis: C, 58.14; H, 4.66; F, 12.54; N, 24.66

Price and Availability

Size Price Availability Quantity
5mg USD 350 2 Weeks
10mg USD 550 2 Weeks
25mg USD 1150 2 Weeks
50mg USD 1750 2 Weeks
100mg USD 2650 2 Weeks
Bulk inquiry

Synonym: GW779439X;

IUPAC/Chemical Name: N-[4-(4-Methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine

InChi Key: ZOTNSCLLJKXGSD-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H21F3N8/c1-31-9-11-32(12-10-31)20-5-4-15(13-17(20)22(23,24)25)29-21-26-8-6-18(30-21)16-14-28-33-19(16)3-2-7-27-33/h2-8,13-14H,9-12H2,1H3,(H,26,29,30)

SMILES Code: FC(C1=CC(NC2=NC=CC(C3=C4C=CC=NN4N=C3)=N2)=CC=C1N5CCN(C)CC5)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:
Biological target: GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway.
In vitro activity: As can be seen in Table 1, GW779439X was able to potentiate the activity of all β-lactams tested, particularly the penicillinase-resistant penicillins oxacillin and nafcillin to an MIC considered susceptible to these agents. Reference: ACS Infect Dis. 2018 Oct 12;4(10):1508-1518. https://pubmed.ncbi.nlm.nih.gov/30059625/
In vivo activity: TBD

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.3 68.76

Preparing Stock Solutions

The following data is based on the product molecular weight 454.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Schaenzer AJ, Wlodarchak N, Drewry DH, Zuercher WJ, Rose WE, Ferrer CA, Sauer JD, Striker R. GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against β-Lactam-Resistant Staphylococcus aureus. ACS Infect Dis. 2018 Oct 12;4(10):1508-1518. doi: 10.1021/acsinfecdis.8b00136. Epub 2018 Aug 15. PMID: 30059625; PMCID: PMC6779124.
In vitro protocol: 1. Schaenzer AJ, Wlodarchak N, Drewry DH, Zuercher WJ, Rose WE, Ferrer CA, Sauer JD, Striker R. GW779439X and Its Pyrazolopyridazine Derivatives Inhibit the Serine/Threonine Kinase Stk1 and Act As Antibiotic Adjuvants against β-Lactam-Resistant Staphylococcus aureus. ACS Infect Dis. 2018 Oct 12;4(10):1508-1518. doi: 10.1021/acsinfecdis.8b00136. Epub 2018 Aug 15. PMID: 30059625; PMCID: PMC6779124.
In vivo protocol: TBD

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