WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 592359
CAS#: 7561-71-9
Description: Trinactin is a Homolog of nonactin that has Immunosuppressive effects.
MedKoo Cat#: 592359
Name: Trinactin
CAS#: 7561-71-9
Chemical Formula: C43H70O12
Exact Mass: 778.4867
Molecular Weight: 779.02
Elemental Analysis: C, 66.30; H, 9.06; O, 24.64
Synonym: Trinactin; Akd-1D; Akd 1D; Akd1D
IUPAC/Chemical Name: 5,14,23-Tridemethyl-5,14,23-triethylnonactin
InChi Key: DFQMKYUSAALDDY-WATWMZDWSA-N
InChi Code: InChI=1S/C43H70O12/c1-9-29-21-33-13-17-36(50-33)25(5)40(44)48-24(4)20-32-12-16-37(49-32)26(6)41(45)53-30(10-2)22-34-14-18-39(51-34)28(8)43(47)55-31(11-3)23-35-15-19-38(52-35)27(7)42(46)54-29/h24-39H,9-23H2,1-8H3/t24-,25-,26+,27+,28-,29+,30+,31-,32-,33+,34+,35+,36-,37+,38+,39-/m0/s1
SMILES Code: CC[C@H](OC([C@H]([C@H]1O[C@@H](C[C@@H](CC)OC([C@@H]([C@@H]2O[C@H](C[C@@H](OC([C@H]([C@H]3O[C@@H](C[C@@H](CC)O4)CC3)C)=O)C)CC2)C)=O)CC1)C)=O)C[C@H](O5)CC[C@@H]5[C@@H](C)C4=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 779.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Tanouchi Y, Shichi H. Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Jpn J Ophthalmol. 1987;31(2):218-29. PubMed PMID: 3499534.
2: Hladky SB. Steady-state ion transport by nonactin and trinactin. Biochim Biophys Acta. 1975 Feb 14;375(3):350-62. PubMed PMID: 1173049.
3: Hladky SB. Tests of the carrier model for ion transport by nonactin and trinactin. Biochim Biophys Acta. 1975 Feb 14;375(3):327-49. PubMed PMID: 1173048.
4: Haneda M, Nawata Y, Hayashi T, Ando K. Tetranactin, a new miticidal antibiotic. VI. Determination of dinactin, trinactin and tetranactin in their mixtures by NMR spectroscopy. J Antibiot (Tokyo). 1974 Jul;27(7):555-7. PubMed PMID: 4457535.
5: Kemp G, Wenner C. Cation binding by valinomycin and trinactin at the airwater interface. Cooperativity in cation binding by valinomycin. Biochim Biophys Acta. 1973 Oct 11;323(2):161-6. PubMed PMID: 4752281.
6: Graven SN, Lardy HA, Rutter A. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Biochemistry. 1966 May;5(5):1735-42. PubMed PMID: 5962273.
7: Graven SN, Lardy HA, Johnson D, Rutter A. Antibiotics as tools for metabolic studies. V. Effect of nonactin, monactin, dinactin, and trinactin on oxidative phosphorylation and adenosine triphosphatase induction. Biochemistry. 1966 May;5(5):1729-35. PubMed PMID: 4225380.
8: MEYERS E, PANSY FE, PERLMAN D, SMITH DA, WEISENBORN FL. THE IN VITRO ACTIVITY OF NONACTIN AND ITS HOMOLOGS: MONACTIN, DINACTIN AND TRINACTIN. J Antibiot (Tokyo). 1965 May;18:128-9. PubMed PMID: 14336167.
