Gea 857

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598101

CAS#: 120493-42-7

Description: Gea 857 is a putative blocker of potassium conductance.


Chemical Structure

img
Gea 857
CAS# 120493-42-7

Theoretical Analysis

MedKoo Cat#: 598101
Name: Gea 857
CAS#: 120493-42-7
Chemical Formula: C15H22ClNO2
Exact Mass: 283.1339
Molecular Weight: 283.79
Elemental Analysis: C, 63.48; H, 7.81; Cl, 12.49; N, 4.94; O, 11.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Gea 857; Gea-857; Gea857;

IUPAC/Chemical Name: 1-(4-chlorophenyl)-2-methylpropan-2-yl L-valinate

InChi Key: YKRSWMGPYKJOBF-ZDUSSCGKSA-N

InChi Code: InChI=1S/C15H22ClNO2/c1-10(2)13(17)14(18)19-15(3,4)9-11-5-7-12(16)8-6-11/h5-8,10,13H,9,17H2,1-4H3/t13-/m0/s1

SMILES Code: N[C@@H](C(C)C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 283.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Hu PS, Ross SB. NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. Pharmacol Toxicol. 1997 Feb;80(2):97-102. PubMed PMID: 9060041.

2: Ogren SO, Bartfai T, Hedlund B, Lindberg UH. GEA 857, a putative blocker of potassium conductance, enhances muscarinic agonist-evoked responses: dissociation from an action on 5-HT mechanisms. Pharmacol Toxicol. 1992 Aug;71(2):112-9. PubMed PMID: 1438027.

3: Hedlund B, Ogren SO. GEA 857 blocks potassium channels in the membrane and, thereby, prolongs muscarinic cholinergic responses in N1E-115 neuroblastoma cells. Pharmacol Toxicol. 1992 Aug;71(2):107-11. PubMed PMID: 1301072.