Gea 857

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598101

CAS#: 120493-42-7

Description: Gea 857 is a putative blocker of potassium conductance.

Chemical Structure

Gea 857
CAS# 120493-42-7

Theoretical Analysis

MedKoo Cat#: 598101
Name: Gea 857
CAS#: 120493-42-7
Chemical Formula: C15H22ClNO2
Exact Mass: 283.13
Molecular Weight: 283.790
Elemental Analysis: C, 63.48; H, 7.81; Cl, 12.49; N, 4.94; O, 11.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Gea 857; Gea-857; Gea857;

IUPAC/Chemical Name: 1-(4-chlorophenyl)-2-methylpropan-2-yl L-valinate


InChi Code: InChI=1S/C15H22ClNO2/c1-10(2)13(17)14(18)19-15(3,4)9-11-5-7-12(16)8-6-11/h5-8,10,13H,9,17H2,1-4H3/t13-/m0/s1

SMILES Code: N[C@@H](C(C)C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 283.790000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hu PS, Ross SB. NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. Pharmacol Toxicol. 1997 Feb;80(2):97-102. PubMed PMID: 9060041. 2: Ogren SO, Bartfai T, Hedlund B, Lindberg UH. GEA 857, a putative blocker of potassium conductance, enhances muscarinic agonist-evoked responses: dissociation from an action on 5-HT mechanisms. Pharmacol Toxicol. 1992 Aug;71(2):112-9. PubMed PMID: 1438027. 3: Hedlund B, Ogren SO. GEA 857 blocks potassium channels in the membrane and, thereby, prolongs muscarinic cholinergic responses in N1E-115 neuroblastoma cells. Pharmacol Toxicol. 1992 Aug;71(2):107-11. PubMed PMID: 1301072.