Gea 857

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MedKoo CAT#: 598101

CAS#: 120493-42-7

Description: Gea 857 is a putative blocker of potassium conductance.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-07-04. Prices are subject to change without notice.

Gea 857 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 598101
Name: Gea 857
CAS#: 120493-42-7
Chemical Formula: C15H22ClNO2
Exact Mass: 283.1339
Molecular Weight: 283.79
Elemental Analysis: C, 63.48; H, 7.81; Cl, 12.49; N, 4.94; O, 11.28

Synonym: Gea 857; Gea-857; Gea857;

IUPAC/Chemical Name: 1-(4-chlorophenyl)-2-methylpropan-2-yl L-valinate


InChi Code: InChI=1S/C15H22ClNO2/c1-10(2)13(17)14(18)19-15(3,4)9-11-5-7-12(16)8-6-11/h5-8,10,13H,9,17H2,1-4H3/t13-/m0/s1

SMILES Code: N[C@@H](C(C)C)C(OC(C)(C)CC1=CC=C(Cl)C=C1)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Hu PS, Ross SB. NMDA receptor-mediated increase in cyclic GMP in the rat cerebellum in vivo is blocked by alaproclate and GEA-857. Pharmacol Toxicol. 1997 Feb;80(2):97-102. PubMed PMID: 9060041.

2: Ogren SO, Bartfai T, Hedlund B, Lindberg UH. GEA 857, a putative blocker of potassium conductance, enhances muscarinic agonist-evoked responses: dissociation from an action on 5-HT mechanisms. Pharmacol Toxicol. 1992 Aug;71(2):112-9. PubMed PMID: 1438027.

3: Hedlund B, Ogren SO. GEA 857 blocks potassium channels in the membrane and, thereby, prolongs muscarinic cholinergic responses in N1E-115 neuroblastoma cells. Pharmacol Toxicol. 1992 Aug;71(2):107-11. PubMed PMID: 1301072.