WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563364
Description: JCP174 is an inhibitor of a depalmitoylase that enhances Toxoplasma host-cell invasion by targeting TgPPT1.
MedKoo Cat#: 563364
Chemical Formula: C12H12ClNO3
Exact Mass: 253.0506
Molecular Weight: 253.68
Elemental Analysis: C, 56.82; H, 4.77; Cl, 13.97; N, 5.52; O, 18.92
Synonym: JCP174; JCP-174; JCP 174;
IUPAC/Chemical Name: 7-Amino-4-chloro-3-propoxy-isocoumarin
InChi Key: MDOWUFTZOHGGHU-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H12ClNO3/c1-2-5-16-12-10(13)8-4-3-7(14)6-9(8)11(15)17-12/h3-4,6H,2,5,14H2,1H3
SMILES Code: O=C1OC(OCCC)=C(Cl)C2=C1C=C(N)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 253.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Garland M, Schulze CJ, Foe IT, van der Linden WA, Child MA, Bogyo M. Development of an activity-based probe for acyl-protein thioesterases. PLoS One. 2018 Jan 24;13(1):e0190255. doi: 10.1371/journal.pone.0190255. eCollection 2018. PubMed PMID: 29364904; PubMed Central PMCID: PMC5783350.