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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563363

CAS#: 192718-06-2

Description: C527 is a inhibitor of USP1 target ID1 degradation in leukemic cells.

Price and Availability

Size Price Shipping out time Quantity
5mg USD 270 2 Weeks
25mg USD 650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-02-27. Prices are subject to change without notice.

C527, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 563363
Name: C527
CAS#: 192718-06-2
Chemical Formula: C17H8FNO3
Exact Mass: 293.0488
Molecular Weight: 293.25
Elemental Analysis: C, 69.63; H, 2.75; F, 6.48; N, 4.78; O, 16.37

Synonym: C527; C-527; C 527;

IUPAC/Chemical Name: 2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione


InChi Code: InChI=1S/C17H8FNO3/c18-10-7-5-9(6-8-10)17-19-13-14(20)11-3-1-2-4-12(11)15(21)16(13)22-17/h1-8H

SMILES Code: O=C(C1=C2OC(C3=CC=C(F)C=C3)=N1)C4=C(C=CC=C4)C2=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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3: Ostrom RS. A new molecular target for blunting organ fibrosis. Focus on "Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention". Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C527-8. doi: 10.1152/ajpcell.00020.2014. Epub 2014 Jan 22. PubMed PMID: 24452379.

4: Cuddapah VA, Habela CW, Watkins S, Moore LS, Barclay TT, Sontheimer H. Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding. Am J Physiol Cell Physiol. 2012 Feb 1;302(3):C527-38. doi: 10.1152/ajpcell.00248.2011. Epub 2011 Nov 2. PubMed PMID: 22049206; PubMed Central PMCID: PMC3287156.

5: Capolicchio JP. Laparoscopic extravesical ureteral reimplantation: technique. Adv Urol. 2008:567980. doi: 10.1155/2008/567980. PubMed PMID: 18725984; PubMed Central PMCID: PMC2517660.

6: Chen YC, Tou JC, Jaczynski J. Amino acid, fatty acid, and mineral profiles of materials recovered from rainbow trout (Oncorhynchus mykiss) processing by-products using isoelectric solubilization/precipitation. J Food Sci. 2007 Nov;72(9):C527-35. PubMed PMID: 18034715.

7: Kockskämper J, Ahmmed GU, Zima AV, Sheehan KA, Glitsch HG, Blatter LA. Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps. Am J Physiol Cell Physiol. 2004 Aug;287(2):C527-38. Epub 2004 Apr 14. PubMed PMID: 15084477.

8: Decaens C, Cassio D. Spatiotemporal expression of catenins, ZO-1, and occludin during early polarization of hepatic WIF-B9 cells. Am J Physiol Cell Physiol. 2001 Mar;280(3):C527-39. PubMed PMID: 11171572.

9: Hedges JC, Yamboliev IA, Ngo M, Horowitz B, Adam LP, Gerthoffer WT. p38 mitogen-activated protein kinase expression and activation in smooth muscle. Am J Physiol. 1998 Aug;275(2 Pt 1):C527-34. PubMed PMID: 9688607.

10: Unguez GA, Roy RR, Pierotti DJ, Bodine-Fowler S, Edgerton VR. Further evidence of incomplete neural control of muscle properties in cat tibialis anterior motor units. Am J Physiol. 1995 Feb;268(2 Pt 1):C527-34. PubMed PMID: 7864092.

11: Shetty M, Ismail-Beigi N, Loeb JN, Ismail-Beigi F. Induction of GLUT1 mRNA in response to inhibition of oxidative phosphorylation. Am J Physiol. 1993 Nov;265(5 Pt 1):C1224-9. PubMed PMID: 7694490.

12: Vogalis F, Lang RJ, Bywater RA, Taylor GS. Voltage-gated ionic currents in smooth muscle cells of guinea pig proximal colon. Am J Physiol. 1993 Mar;264(3 Pt 1):C527-36. PubMed PMID: 8384782.

13: Shetty M, Loeb JN, Ismail-Beigi F. Enhancement of glucose transport in response to inhibition of oxidative metabolism: pre- and posttranslational mechanisms. Am J Physiol. 1992 Feb;262(2 Pt 1):C527-32. PubMed PMID: 1539639.

14: Restrepo D, Cronise BL, Snyder RB, Spinelli LJ, Knauf PA. Kinetics of DIDS inhibition of HL-60 cell anion exchange rules out ping-pong model with slippage. Am J Physiol. 1991 Mar;260(3 Pt 1):C535-44. PubMed PMID: 1848401.

15: Serrano-Castro A, de Abajo FJ, Sánchez-García P. Li+ as a secretagogue agent. Am J Physiol. 1990 Sep;259(3 Pt 1):C527-9. PubMed PMID: 2169199.

16: Ahn J, Chang EB, Field M. Phorbol ester inhibition of Na-H exchange in rabbit proximal colon. Am J Physiol. 1985 Nov;249(5 Pt 1):C527-30. PubMed PMID: 3864381.

17: Pace CS, Goldsmith KT. Action of a phorbol ester on B-cells: potentiation of stimulant-induced electrical activity. Am J Physiol. 1985 May;248(5 Pt 1):C527-34. PubMed PMID: 3158214.