S 2484

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598085

CAS#: 86190-22-9

Description: S 2484 is a chromogranic specific substrate for granulocyte elastase.

Chemical Structure

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S 2484
CAS# 86190-22-9
Instruction

Theoretical Analysis

MedKoo Cat#: 598085
Name: S 2484
CAS#: 86190-22-9
Chemical Formula: C21H29N5O7
Exact Mass: 463.21
Molecular Weight: 463.490
Elemental Analysis: C, 54.42; H, 6.31; N, 15.11; O, 24.16

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: S 2484; S-2484; S2484; Pyro-glu-pro-val-pna;

IUPAC/Chemical Name: (S)-4-amino-5-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)(4-nitrophenyl)carbamoyl)pyrrolidin-1-yl)-5-oxopentanoic acid

InChi Key: WPSYDPBAHWFTEJ-BQFCYCMXSA-N

InChi Code: InChI=1S/C21H29N5O7/c1-12(2)18(19(23)29)25(13-5-7-14(8-6-13)26(32)33)21(31)16-4-3-11-24(16)20(30)15(22)9-10-17(27)28/h5-8,12,15-16,18H,3-4,9-11,22H2,1-2H3,(H2,23,29)(H,27,28)/t15-,16-,18-/m0/s1

SMILES Code: CC(C)[C@@H](C(N)=O)N(C([C@H]1N(C([C@H](CCC(O)=O)N)=O)CCC1)=O)C2=CC=C([N+]([O-])=O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 463.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tanaka H, Shimazu T, Sugimoto H, Yoshioka T, Sugimoto T. A sensitive and specific assay for granulocyte elastase in inflammatory tissue fluid using L-pyroglutamyl-L-prolyl-L-valine-p-nitroanilide. Clin Chim Acta. 1990 Feb 28;187(2):173-80. PubMed PMID: 2317934.

2: Hamanaka K, Toki N, Takasugi S, Sumi H. Effect of plant SH-protease on human polymorphonuclear leukocyte granule elastase. J Dermatol. 1984 Dec;11(6):523-8. PubMed PMID: 6399052.

3: Regan J, McGarry D, Bruno J, Green D, Newman J, Hsu CY, Kline J, Barton J, Travis J, Choi YM, Volz F, Pauls H, Harrison R, Zilberstein A, Ben-Sasson SA, Chang M. Anionic- and lipophilic-mediated surface binding inhibitors of human leukocyte elastase. J Med Chem. 1997 Oct 10;40(21):3408-22. PubMed PMID: 9341916.

4: Figueredo CM, Gustafsson A, Asman B, Bergström K. Increased release of elastase from in vitro activated peripheral neutrophils in patients with adult periodontitis. J Clin Periodontol. 1999 Apr;26(4):206-11. PubMed PMID: 10223390.

5: Kramps JA, van Twisk C, van der Linden AC. L-Pyroglutamyl-L-prolyl-L-valine-p-nitroanilide, a highly specific substrate for granulocyte elastase. Scand J Clin Lab Invest. 1983 Sep;43(5):427-32. PubMed PMID: 6557666.

6: Kramps JA, Morrison HM, Burnett D, Dijkman JH, Stockley RA. Determination of elastase inhibitory activity of alpha 1-proteinase inhibitor and bronchial antileukoprotease: different results using insoluble elastin or synthetic low molecular weight substrates. Scand J Clin Lab Invest. 1987 Jun;47(4):405-10. PubMed PMID: 2440098.