t-Boc-N-amido-PEG3-CH2CO2H
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 572108

CAS#: 462100-06-7

Description: t-Boc-N-amido-PEG3-CH2CO2H is a PEG derivative containing a terminal carboxylic acid and Boc-protected amino group. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Structure

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t-Boc-N-amido-PEG3-CH2CO2H
CAS# 462100-06-7
Instruction

Theoretical Analysis

MedKoo Cat#: 572108
Name: t-Boc-N-amido-PEG3-CH2CO2H
CAS#: 462100-06-7
Chemical Formula: C13H25NO7
Exact Mass: 307.16
Molecular Weight: 307.340
Elemental Analysis: C, 50.80; H, 8.20; N, 4.56; O, 36.44

Price and Availability

Size Price Availability Quantity
500mg USD 420
1g USD 615
2g USD 950
5g USD 1850
10g USD 2950
20g USD 4950
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Synonym: t-Boc-N-amido-PEG3-CH2CO2H

IUPAC/Chemical Name: 2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azahexadecan-16-oic acid

InChi Key: IFSMYFLQPDFUOI-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H25NO7/c1-13(2,3)21-12(17)14-4-5-18-6-7-19-8-9-20-10-11(15)16/h4-10H2,1-3H3,(H,14,17)(H,15,16)

SMILES Code: CC(C)(C)OC(NCCOCCOCCOCC(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info: The hydrophilic PEG spacer increases solubility in aqueous media.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 307.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang P, Huang Y, Liu H, Marquez RT, Lu J, Zhao W, Zhang X, Gao X, Li J, Venkataramanan R, Xu L, Li S. A PEG-Fmoc conjugate as a nanocarrier for paclitaxel. Biomaterials. 2014 Aug;35(25):7146-56. doi: 10.1016/j.biomaterials.2014.04.108. Epub 2014 May 22. PubMed PMID: 24856103; PubMed Central PMCID: PMC4102141.

2: Salmaso S, Bersani S, Scomparin A, Mastrotto F, Scherpfer R, Tonon G, Caliceti P. Tailored PEG for rh-G-CSF analogue site-specific conjugation. Bioconjug Chem. 2009 Jun;20(6):1179-85. doi: 10.1021/bc9000432. PubMed PMID: 19469471.