Thyroxine sulfate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598073

CAS#: 77074-49-8

Description: Thyroxine sulfate is a metabolite and sulfoconjugated derivative of Thyroxine.

Chemical Structure

Thyroxine sulfate
CAS# 77074-49-8

Theoretical Analysis

MedKoo Cat#: 598073
Name: Thyroxine sulfate
CAS#: 77074-49-8
Chemical Formula: C15H11I4NO7S
Exact Mass: 856.6435
Molecular Weight: 856.93
Elemental Analysis: C, 21.02; H, 1.29; I, 59.24; N, 1.63; O, 13.07; S, 3.74

Price and Availability

Size Price Availability Quantity
10.0mg USD 300.0 2 Weeks
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Synonym: Thyroxine sulfate; T4 Sulfate;

IUPAC/Chemical Name: (S)-2-amino-3-(4-(3,5-diiodo-4-(sulfooxy)phenoxy)-3,5-diiodophenyl)propanoic acid


InChi Code: InChI=1S/C15H11I4NO7S/c16-8-1-6(3-12(20)15(21)22)2-9(17)13(8)26-7-4-10(18)14(11(19)5-7)27-28(23,24)25/h1-2,4-5,12H,3,20H2,(H,21,22)(H,23,24,25)/t12-/m0/s1

SMILES Code: N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(OS(=O)(O)=O)C(I)=C2)C(I)=C1)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 856.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Manna D, Mondal S, Mugesh G. Halogen bonding controls the regioselectivity of the deiodination of thyroid hormones and their sulfate analogues. Chemistry. 2015 Feb 2;21(6):2409-16. doi: 10.1002/chem.201405442. Epub 2014 Dec 8. PubMed PMID: 25487845.

2: Huang WS, Cherng SC, Wang CH, Shih BF, Kuo SW, Wu SY. Increased urinary thyroxine sulfate excretion in thyroxine therapy. Endocr J. 1997 Aug;44(4):467-72. Erratum in: Endocr J 1997 Oct;44(5):following 764. PubMed PMID: 9447277.

3: Wu SY, Huang WS, Polk D, Florsheim WH, Green WL, Fisher DA. Identification of thyroxine-sulfate (T4S) in human serum and amniotic fluid by a novel T4S radioimmunoassay. Thyroid. 1992 Summer;2(2):101-5. PubMed PMID: 1525576.

4: Peeters RP, Kester MH, Wouters PJ, Kaptein E, van Toor H, Visser TJ, Van den Berghe G. Increased thyroxine sulfate levels in critically ill patients as a result of a decreased hepatic type I deiodinase activity. J Clin Endocrinol Metab. 2005 Dec;90(12):6460-5. Epub 2005 Sep 27. PubMed PMID: 16189257.

5: Chopra IJ, Santini F, Hurd RE, Chua Teco GN. A radioimmunoassay for measurement of thyroxine sulfate. J Clin Endocrinol Metab. 1993 Jan;76(1):145-50. PubMed PMID: 8421080.

6: Mol JA, Visser TJ. Rapid and selective inner ring deiodination of thyroxine sulfate by rat liver deiodinase. Endocrinology. 1985 Jul;117(1):8-12. PubMed PMID: 4006868.

7: Wu SY, Polk DH, Huang WS, Reviczky A, Wang K, Fisher DA. Sulfate conjugates of iodothyronines in developing sheep: effect of fetal hypothyroidism. Am J Physiol. 1993 Jul;265(1 Pt 1):E115-20. PubMed PMID: 8338144.

8: Wu S, Polk D, Wong S, Reviczky A, Vu R, Fisher DA. Thyroxine sulfate is a major thyroid hormone metabolite and a potential intermediate in the monodeiodination pathways in fetal sheep. Endocrinology. 1992 Oct;131(4):1751-6. PubMed PMID: 1396320.

9: Kung MP, Spaulding SW, Roth JA. Desulfation of 3,5,3'-triiodothyronine sulfate by microsomes from human and rat tissues. Endocrinology. 1988 Apr;122(4):1195-200. PubMed PMID: 2964360.

10: Rutgers M, Pigmans IG, Bonthuis F, Docter R, Visser TJ. Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate. Endocrinology. 1989 Oct;125(4):2175-86. PubMed PMID: 2791984.

11: Bernus I, Mitchell AM, Manley SW, Mortimer RH. Lack of membrane transport of l-thyroxine sulphate in the human choriocarcinoma cell line, JAr. Placenta. 2000 Mar-Apr;21(2-3):283-5. PubMed PMID: 10736255.

12: Wu SY, Polk DH, Huang WS, Ho E, Kattan JM, Fisher DA. 3'-monoiodothyronine sulfate and Triac sulfate are thyroid hormone metabolites in developing sheep. Pediatr Res. 2008 Feb;63(2):149-53. PubMed PMID: 18091342.

13: Tang RB, Liu DL, Dong JZ, Liu XP, Long DY, Yu RH, Hu FL, Wu JH, Liu XH, Ma CS. High-normal thyroid function and risk of recurrence of atrial fibrillation after catheter ablation. Circ J. 2010 Jul;74(7):1316-21. Epub 2010 May 27. PubMed PMID: 20508382.

14: van der Deure WM, Friesema EC, de Jong FJ, de Rijke YB, de Jong FH, Uitterlinden AG, Breteler MM, Peeters RP, Visser TJ. Organic anion transporter 1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism. Endocrinology. 2008 Sep;149(9):4695-701. doi: 10.1210/en.2008-0169. Epub 2008 May 22. PubMed PMID: 18499754.

15: Polk DH, Reviczky A, Wu SY, Huang WS, Fisher DA. Metabolism of sulfoconjugated thyroid hormone derivatives in developing sheep. Am J Physiol. 1994 Jun;266(6 Pt 1):E892-6. PubMed PMID: 8023919.

16: Wu SY, Huang WS, Chopra IJ, Jordan M, Alvarez D, Santini F. Sulfation pathway of thyroid hormone metabolism in selenium-deficient male rats. Am J Physiol. 1995 Apr;268(4 Pt 1):E572-9. PubMed PMID: 7733254.