WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598073
CAS#: 77074-49-8
Description: Thyroxine sulfate is a metabolite and sulfoconjugated derivative of Thyroxine.
MedKoo Cat#: 598073
Name: Thyroxine sulfate
CAS#: 77074-49-8
Chemical Formula: C15H11I4NO7S
Exact Mass: 856.6435
Molecular Weight: 856.93
Elemental Analysis: C, 21.02; H, 1.29; I, 59.24; N, 1.63; O, 13.07; S, 3.74
Synonym: Thyroxine sulfate; T4 Sulfate;
IUPAC/Chemical Name: (S)-2-amino-3-(4-(3,5-diiodo-4-(sulfooxy)phenoxy)-3,5-diiodophenyl)propanoic acid
InChi Key: QYXIJUZWSSQICT-LBPRGKRZSA-N
InChi Code: InChI=1S/C15H11I4NO7S/c16-8-1-6(3-12(20)15(21)22)2-9(17)13(8)26-7-4-10(18)14(11(19)5-7)27-28(23,24)25/h1-2,4-5,12H,3,20H2,(H,21,22)(H,23,24,25)/t12-/m0/s1
SMILES Code: N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(OS(=O)(O)=O)C(I)=C2)C(I)=C1)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 856.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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6: Mol JA, Visser TJ. Rapid and selective inner ring deiodination of thyroxine sulfate by rat liver deiodinase. Endocrinology. 1985 Jul;117(1):8-12. PubMed PMID: 4006868.
7: Wu SY, Polk DH, Huang WS, Reviczky A, Wang K, Fisher DA. Sulfate conjugates of iodothyronines in developing sheep: effect of fetal hypothyroidism. Am J Physiol. 1993 Jul;265(1 Pt 1):E115-20. PubMed PMID: 8338144.
8: Wu S, Polk D, Wong S, Reviczky A, Vu R, Fisher DA. Thyroxine sulfate is a major thyroid hormone metabolite and a potential intermediate in the monodeiodination pathways in fetal sheep. Endocrinology. 1992 Oct;131(4):1751-6. PubMed PMID: 1396320.
9: Kung MP, Spaulding SW, Roth JA. Desulfation of 3,5,3'-triiodothyronine sulfate by microsomes from human and rat tissues. Endocrinology. 1988 Apr;122(4):1195-200. PubMed PMID: 2964360.
10: Rutgers M, Pigmans IG, Bonthuis F, Docter R, Visser TJ. Effects of propylthiouracil on the biliary clearance of thyroxine (T4) in rats: decreased excretion of 3,5,3'-triiodothyronine glucuronide and increased excretion of 3,3',5'-triiodothyronine glucuronide and T4 sulfate. Endocrinology. 1989 Oct;125(4):2175-86. PubMed PMID: 2791984.
11: Bernus I, Mitchell AM, Manley SW, Mortimer RH. Lack of membrane transport of l-thyroxine sulphate in the human choriocarcinoma cell line, JAr. Placenta. 2000 Mar-Apr;21(2-3):283-5. PubMed PMID: 10736255.
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13: Tang RB, Liu DL, Dong JZ, Liu XP, Long DY, Yu RH, Hu FL, Wu JH, Liu XH, Ma CS. High-normal thyroid function and risk of recurrence of atrial fibrillation after catheter ablation. Circ J. 2010 Jul;74(7):1316-21. Epub 2010 May 27. PubMed PMID: 20508382.
14: van der Deure WM, Friesema EC, de Jong FJ, de Rijke YB, de Jong FH, Uitterlinden AG, Breteler MM, Peeters RP, Visser TJ. Organic anion transporter 1B1: an important factor in hepatic thyroid hormone and estrogen transport and metabolism. Endocrinology. 2008 Sep;149(9):4695-701. doi: 10.1210/en.2008-0169. Epub 2008 May 22. PubMed PMID: 18499754.
15: Polk DH, Reviczky A, Wu SY, Huang WS, Fisher DA. Metabolism of sulfoconjugated thyroid hormone derivatives in developing sheep. Am J Physiol. 1994 Jun;266(6 Pt 1):E892-6. PubMed PMID: 8023919.
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