WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563350
CAS#: 881639-98-1
Description: G-1 is a selective agonist for GPER. It acts by blocking tubulin polymerization.
MedKoo Cat#: 563350
Name: G-1 GPER inhibitor
CAS#: 881639-98-1
Chemical Formula: C21H18BrNO3
Exact Mass: 411.047
Molecular Weight: 412.28
Elemental Analysis: C, 61.18; H, 4.40; Br, 19.38; N, 3.40; O, 11.64
Synonym: G-1; G 1; G1; G-1 GPER inhibitor,
IUPAC/Chemical Name: Syn-1-[4-(6-bromobenzo[1,3] dioxol-5yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone
InChi Key: VHSVKVWHYFBIFJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3
SMILES Code: CC(C1=CC2=C(NC(C3=C(Br)C=C(OCO4)C4=C3)C5C2C=CC5)C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 412.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Thomas P. Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models. Gen Comp Endocrinol. 2012 Feb 1;175(3):367-83. doi: 10.1016/j.ygcen.2011.11.032. Epub 2011 Nov 29. Review. PubMed PMID: 22154643; PubMed Central PMCID: PMC3264783.
2: Revankar CM, Mitchell HD, Field AS, Burai R, Corona C, Ramesh C, Sklar LA, Arterburn JB, Prossnitz ER. Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. ACS Chem Biol. 2007 Aug 17;2(8):536-44. Epub 2007 Jul 27. PubMed PMID: 17655271.
3: Song RX, Fan P, Yue W, Chen Y, Santen RJ. Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer. Endocr Relat Cancer. 2006 Dec;13 Suppl 1:S3-13. Review. PubMed PMID: 17259556.
4: Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science. 2005 Mar 11;307(5715):1625-30. Epub 2005 Feb 10. PubMed PMID: 15705806.
