WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598024
CAS#: 114376-16-8
Description: U 70714E is a synthetic peptide inhibitors of human renin.
MedKoo Cat#: 598024
Name: U 70714E
CAS#: 114376-16-8
Chemical Formula: C66H76N12O10
Exact Mass: 1196.5807
Molecular Weight: 1197.4
Elemental Analysis: C, 66.20; H, 6.40; N, 14.04; O, 13.36
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Synonym: U 70714E; U-70714E; U70714E;
IUPAC/Chemical Name: (S)-1-(Na-acetyl-1-formyl-L-tryptophyl)-N-((S)-1-(((S)-1-(((S)-1-(((S)-1-(((S)-1-(((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-phenylpropan-2-yl)amino)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide
InChi Key: FFSCESWJZKPQHE-XVLSDOAMSA-N
InChi Code: InChI=1S/C66H76N12O10/c1-41(2)59(65(87)73-52(60(67)82)31-46-25-27-50(81)28-26-46)76-61(83)53(32-44-18-9-5-10-19-44)69-37-49(30-43-16-7-4-8-17-43)72-62(84)55(35-48-36-68-39-70-48)74-63(85)54(33-45-20-11-6-12-21-45)75-64(86)58-24-15-29-78(58)66(88)56(71-42(3)80)34-47-38-77(40-79)57-23-14-13-22-51(47)57/h4-14,16-23,25-28,36,38-41,49,52-56,58-59,69,81H,15,24,29-35,37H2,1-3H3,(H2,67,82)(H,68,70)(H,71,80)(H,72,84)(H,73,87)(H,74,85)(H,75,86)(H,76,83)/t49-,52-,53-,54-,55-,56-,58-,59-/m0/s1
SMILES Code: OC1=CC=C(C=C1)C[C@@H](C(N)=O)NC([C@H](C(C)C)NC([C@H](CC2=CC=CC=C2)NC[C@@H](NC([C@H](CC3=CNC=N3)NC([C@H](CC4=CC=CC=C4)NC([C@H]5N(C([C@H](CC6=CN(C=O)C7=C6C=CC=C7)NC(C)=O)=O)CCC5)=O)=O)=O)CC8=CC=CC=C8)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 1197.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Epps DE, Mao B, Staples DJ, Sawyer TK. Structure-conformation relationships of synthetic peptide inhibitors of human renin studied by resonance energy transfer and molecular modeling. Int J Pept Protein Res. 1988 Jan;31(1):22-34. PubMed PMID: 3284834.