WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598022
CAS#: 93768-49-1
Description: I5B2 is a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp.
MedKoo Cat#: 598022
Name: I5B2
CAS#: 93768-49-1
Chemical Formula: C23H32N3O7P
Exact Mass: 493.1978
Molecular Weight: 493.49
Elemental Analysis: C, 55.98; H, 6.54; N, 8.51; O, 22.69; P, 6.28
This product is not in stock, which may be available by custom synthesis.
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Synonym: I5B2; I5-B2; I5 B2;
IUPAC/Chemical Name: (1-((S)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-3-methyl-2-(methylamino)butanamido)-2-(4-hydroxyphenyl)ethyl)phosphonic acid
InChi Key: CRLOMAVMOUQSOO-YSTUSHMSSA-N
InChi Code: InChI=1S/C23H32N3O7P/c1-14(2)21(25-3)23(30)26(19(22(24)29)12-15-4-8-17(27)9-5-15)20(34(31,32)33)13-16-6-10-18(28)11-7-16/h4-11,14,19-21,25,27-28H,12-13H2,1-3H3,(H2,24,29)(H2,31,32,33)/t19-,20?,21-/m0/s1
SMILES Code: OC1=CC=C(C=C1)C[C@@H](C(N)=O)N(C([C@H](C(C)C)NC)=O)C(P(O)(O)=O)CC2=CC=C(O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 493.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Kido Y, Hamakado T, Anno M, Miyagawa E, Motoki Y, Wakamiya T, Shiba T. Isolation and characterization of I5B2, a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp. J Antibiot (Tokyo). 1984 Sep;37(9):965-9. PubMed PMID: 6094415.
