I5B2

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MedKoo CAT#: 598022

CAS#: 93768-49-1

Description: I5B2 is a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp.


Price and Availability

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Pricing updated 2020-10-25. Prices are subject to change without notice.

I5B2 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 598022
Name: I5B2
CAS#: 93768-49-1
Chemical Formula: C23H32N3O7P
Exact Mass: 493.1978
Molecular Weight: 493.49
Elemental Analysis: C, 55.98; H, 6.54; N, 8.51; O, 22.69; P, 6.28


Synonym: I5B2; I5-B2; I5 B2;

IUPAC/Chemical Name: (1-((S)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-3-methyl-2-(methylamino)butanamido)-2-(4-hydroxyphenyl)ethyl)phosphonic acid

InChi Key: CRLOMAVMOUQSOO-YSTUSHMSSA-N

InChi Code: InChI=1S/C23H32N3O7P/c1-14(2)21(25-3)23(30)26(19(22(24)29)12-15-4-8-17(27)9-5-15)20(34(31,32)33)13-16-6-10-18(28)11-7-16/h4-11,14,19-21,25,27-28H,12-13H2,1-3H3,(H2,24,29)(H2,31,32,33)/t19-,20?,21-/m0/s1

SMILES Code: OC1=CC=C(C=C1)C[C@@H](C(N)=O)N(C([C@H](C(C)C)NC)=O)C(P(O)(O)=O)CC2=CC=C(O)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Kido Y, Hamakado T, Anno M, Miyagawa E, Motoki Y, Wakamiya T, Shiba T. Isolation and characterization of I5B2, a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp. J Antibiot (Tokyo). 1984 Sep;37(9):965-9. PubMed PMID: 6094415.