BW-A 575C

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597866

CAS#: 103221-88-1

Description: BW-A 575C is an ACE inhibitor.


Price and Availability

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BW-A 575C is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597866
Name: BW-A 575C
CAS#: 103221-88-1
Chemical Formula: C29H43N5O8
Exact Mass: 589.3112
Molecular Weight: 589.69
Elemental Analysis: C, 59.07; H, 7.35; N, 11.88; O, 21.70


Synonym: BW-A 575C; BW-B385C; BWB385C; BW B385C;

IUPAC/Chemical Name: (1-carboxy-5-(4-(2-hydroxy-3-(isopropylamino)propoxy)-1H-indole-2-carboxamido)pentyl)alanyl-L-proline

InChi Key: XCLLRLKRCYZTES-PBKHYBTFSA-N

InChi Code: InChI=1S/C29H43N5O8/c1-17(2)31-15-19(35)16-42-25-11-6-9-21-20(25)14-23(33-21)26(36)30-12-5-4-8-22(28(38)39)32-18(3)27(37)34-13-7-10-24(34)29(40)41/h6,9,11,14,17-19,22,24,31-33,35H,4-5,7-8,10,12-13,15-16H2,1-3H3,(H,30,36)(H,38,39)(H,40,41)/t18?,19?,22?,24-/m0/s1

SMILES Code: O=C(O)[C@H]1N(C(C(C)NC(C(O)=O)CCCCNC(C(N2)=CC3=C2C=CC=C3OCC(O)CNC(C)C)=O)=O)CCC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Cambridge D, Allan G, Hardy GW, Follenfant MJ, Ford A, Oliver PL. BW A575C: pharmacological profile in vivo of a novel angiotensin converting enzyme inhibitor and beta-blocker. J Cardiovasc Pharmacol. 1987;10 Suppl 11:S64-8. PubMed PMID: 2454371.

2: Cambridge D, Whiting MV, Allan G. Cardiac and renovascular effects in the anaesthetized dog of BW A575C: a novel angiotensin converting enzyme inhibitor with beta-adrenoceptor blocking properties. Br J Pharmacol. 1988 Jan;93(1):165-75. PubMed PMID: 2894874; PubMed Central PMCID: PMC1853785.

3: Cambridge D, Whiting MV, Butterfield LJ, Allan G. The effects of combined angiotensin converting enzyme inhibition and beta-adrenoceptor blockade on plasma renin activity in anaesthetized dogs. Br J Pharmacol. 1992 Jun;106(2):342-7. PubMed PMID: 1356560; PubMed Central PMCID: PMC1907514.