WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 597844
Description: Ici 186756 is a novel, potent, and selective inhibitor of human neutrophil elastase.
MedKoo Cat#: 597844
Name: Ici 186756
Chemical Formula: C33H49N5O9
Exact Mass: 659.353
Molecular Weight: 659.78
Elemental Analysis: C, 60.07; H, 7.49; N, 10.61; O, 21.82
This product is not in stock, which may be available by custom synthesis.
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Synonym: Ici 186756; Ici--186756; Ici186756;
IUPAC/Chemical Name: 4-(((S)-6-(((benzyloxy)carbonyl)amino)-1-(((S)-3-methyl-1-((S)-2-(((S)-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxobutan-2-yl)amino)-1-oxohexan-2-yl)amino)-4-oxobutanoic acid
InChi Key: MJJMPRRKYVKTAO-BVXNIFABSA-N
InChi Code: InChI=1S/C33H49N5O9/c1-21(2)25(19-39)36-31(44)26-14-10-18-38(26)32(45)29(22(3)4)37-30(43)24(35-27(40)15-16-28(41)42)13-8-9-17-34-33(46)47-20-23-11-6-5-7-12-23/h5-7,11-12,19,21-22,24-26,29H,8-10,13-18,20H2,1-4H3,(H,34,46)(H,35,40)(H,36,44)(H,37,43)(H,41,42)/t24-,25+,26-,29-/m0/s1
SMILES Code: O=C(N[C@H](C=O)C(C)C)[C@H]1N(C([C@H](C(C)C)NC([C@H](CCCCNC(OCC2=CC=CC=C2)=O)NC(CCC(O)=O)=O)=O)=O)CCC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 659.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Williams JC, Stein RL, Strimpler AM, Reaves B, Krell RD. Biochemical and pharmacological characterization of ICI 186,756: a novel, potent, and selective inhibitor of human neutrophil elastase. Exp Lung Res. 1991 Jul-Aug;17(4):725-41. PubMed PMID: 1935833.