Safrole oxide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592168

CAS#: 7470-44-2

Description: Safrole oxide induces endothelial-mesenchymal transition via the ATF4/p75NTR/IL-8 signal pathway.

Chemical Structure

img
Safrole oxide
CAS# 7470-44-2
Instruction

Theoretical Analysis

MedKoo Cat#: 592168
Name: Safrole oxide
CAS#: 7470-44-2
Chemical Formula: C10H10O3
Exact Mass: 178.06
Molecular Weight: 178.190
Elemental Analysis: C, 67.41; H, 5.66; O, 26.94

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Safrole oxide; NSC 402793; NSC-402793; NSC402793

IUPAC/Chemical Name: 5-(oxiran-2-ylmethyl)benzo[d][1,3]dioxole

InChi Key: KZYXVVGEWCXONF-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H10O3/c1-2-9-10(13-6-12-9)4-7(1)3-8-5-11-8/h1-2,4,8H,3,5-6H2

SMILES Code: C1(CC2=CC3=C(C=C2)OCO3)CO1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 178.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Ge D, Jing Q, Zhao W, Yue H, Su L, Zhang S, Zhao J. Finding ATF4/p75NTR/IL-8 signal pathway in endothelial-mesenchymal transition by safrole oxide. PLoS One. 2014 Jun 6;9(6):e99378. doi: 10.1371/journal.pone.0099378. eCollection 2014. PubMed PMID: 24905361; PubMed Central PMCID: PMC4048316.

2: Su L, Zhao J, Zhao BX, Zhang SL, Miao JY. Safrole oxide induces human umbilical vein endothelial cell transdifferentiation to 5-hydroxytryptaminergic neuron-like cells through tropomyosin receptor kinase A/cyclooxygenase 2/nuclear factor-kappa B/interleukin 8 signaling. Int J Biochem Cell Biol. 2011 Oct;43(10):1512-22. doi: 10.1016/j.biocel.2011.07.002. Epub 2011 Jul 13. PubMed PMID: 21777689.

3: Su L, Zhao B, Lv X, Wang N, Zhao J, Zhang S, Miao J. Safrole oxide induces neuronal apoptosis through inhibition of integrin beta4/SOD activity and elevation of ROS/NADPH oxidase activity. Life Sci. 2007 Feb 20;80(11):999-1006. Epub 2006 Dec 1. PubMed PMID: 17188719.

4: Zhao J, Miao J, Zhao B, Zhang S, Yin D. Safrole oxide inhibits angiogenesis by inducing apoptosis. Vascul Pharmacol. 2005 Jun;43(1):69-74. PubMed PMID: 15936989.