WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563286
CAS#: 1287261-04-4
Description: ZYJ-25e is a histone deacetylase inhibitor (HDACi) with potent oral antitumor activities.
MedKoo Cat#: 563286
Name: ZYJ-25e
CAS#: 1287261-04-4
Chemical Formula: C30H40N4O8
Exact Mass: 584.2846
Molecular Weight: 584.67
Elemental Analysis: C, 61.63; H, 6.90; N, 9.58; O, 21.89
This product is not in stock, which may be available by custom synthesis.
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Synonym: ZYJ-25e; ZYJ 25e; ZYJ25e;
IUPAC/Chemical Name: tert-butyl ((2S,3S)-1-((S)-7-(2-(hydroxyamino)-2-oxoethoxy)-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-methyl-1-oxopentan-2-yl)carbamate
InChi Key: UZZNWMWOBYWIST-SQOVJYTMSA-N
InChi Code: InChI=1S/C30H40N4O8/c1-7-18(2)26(32-29(38)42-30(3,4)5)28(37)34-16-20-14-23(41-17-25(35)33-39)11-8-19(20)15-24(34)27(36)31-21-9-12-22(40-6)13-10-21/h8-14,18,24,26,39H,7,15-17H2,1-6H3,(H,31,36)(H,32,38)(H,33,35)/t18-,24-,26-/m0/s1
SMILES Code: ONC(COC1=CC(CN(C([C@H]([C@@H](C)CC)NC(OC(C)(C)C)=O)=O)[C@H](C(NC2=CC=C(OC)C=C2)=O)C3)=C3C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 584.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Flesch-Janys D, Slanger T, Mutschelknauss E, Kropp S, Obi N, Vettorazzi E, Braendle W, Bastert G, Hentschel S, Berger J, Chang-Claude J. Risk of different histological types of postmenopausal breast cancer by type and regimen of menopausal hormone therapy. Int J Cancer. 2008 Aug 15;123(4):933-41. doi: 10.1002/ijc.23655. PubMed PMID: 18506692.
