WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584474
Description: 3CAI is an inhibitor of Akt1 and Akt2 with anticancer activity.
MedKoo Cat#: 584474
Chemical Formula: C10H8ClNO
Exact Mass: 193.0294
Molecular Weight: 193.63
Elemental Analysis: C, 62.03; H, 4.16; Cl, 18.31; N, 7.23; O, 8.26
IUPAC/Chemical Name: 2-chloro-1-(1H-indol-3-yl)-ethanone
InChi Key: LLZQFAXTCYDVTR-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2
SMILES Code: ClCC(C1=CNC2=C1C=CC=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 193.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Kim, D.J., Reddy, K., Kim, M.O., et al. (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo. Cancer Prev. Res. (Phila). 4(11), 1842-1851 (2011).
2. Kim, J.-E., and Kang, T.-C. TRPC3- and ETB receptor-mediated PI3K/AKT activation induces vasogenic edema formation following status epilepticus. Brain Res. 1672, 58-64 (2017).