BW 443C

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 597819

CAS#: 88331-14-0

Description: BW 443C is a selective mu-opioid receptor agonist.


Price and Availability

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BW 443C is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 597819
Name: BW 443C
CAS#: 88331-14-0
Chemical Formula: C35H50N10O12
Exact Mass: 802.361
Molecular Weight: 802.84
Elemental Analysis: C, 52.36; H, 6.28; N, 17.45; O, 23.91


Synonym: BW 443C; BW-443C; BW443C; Tyr-arg-gly-(4-nitro-phe)-pro-NH2;

IUPAC/Chemical Name: (S)-1-((S)-2-(2-((R)-2-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-5-guanidinopentanamido)acetamido)-3-(4-nitrophenyl)propanoyl)pyrrolidine-2-carboxamide diacetate

InChi Key: IDHPVZFSVGWIIP-WMEHTASQSA-N

InChi Code: InChI=1S/C31H42N10O8.2C2H4O2/c32-22(15-18-7-11-21(42)12-8-18)28(45)39-23(3-1-13-36-31(34)35)29(46)37-17-26(43)38-24(16-19-5-9-20(10-6-19)41(48)49)30(47)40-14-2-4-25(40)27(33)44;2*1-2(3)4/h5-12,22-25,42H,1-4,13-17,32H2,(H2,33,44)(H,37,46)(H,38,43)(H,39,45)(H4,34,35,36);2*1H3,(H,3,4)/t22-,23+,24-,25-;;/m0../s1

SMILES Code: O=C(N)[C@H]1N(C([C@H](CC2=CC=C([N+]([O-])=O)C=C2)NC(CNC([C@@H](CCCNC(N)=N)NC([C@H](CC3=CC=C(O)C=C3)N)=O)=O)=O)=O)CCC1.CC(O)=O.CC(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Belvisi MG, Stretton CD, Verleden GM, Ledingham SJ, Yacoub MH, Barnes PJ. Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol (1985). 1992 Mar;72(3):1096-100. PubMed PMID: 1314798.

2: Adcock JJ. Peripheral opioid receptors and the cough reflex. Respir Med. 1991 Jan;85 Suppl A:43-6. Review. PubMed PMID: 1852031.

3: Yeadon M, Wilkinson D, Darley-Usmar V, O'Leary VJ, Payne AN. Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharmacol. 1992;5(1):39-50. PubMed PMID: 1375522.

4: Calatayud S, Quintana E, Esplugues J, Barrachina MD. Role of central oxytocin in the inhibition by endotoxin of distension-stimulated gastric acid secretion. Naunyn Schmiedebergs Arch Pharmacol. 1999 Dec;360(6):676-82. PubMed PMID: 10619185.

5: Bolser DC, DeGennaro FC, O'Reilly S, Chapman RW, Kreutner W, Egan RW, Hey JA. Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea pig. Br J Pharmacol. 1994 Dec;113(4):1344-8. PubMed PMID: 7889290; PubMed Central PMCID: PMC1510532.

6: Adcock JJ, Schneider C, Smith TW. Effects of codeine, morphine and a novel opioid pentapeptide BW443C, on cough, nociception and ventilation in the unanaesthetized guinea-pig. Br J Pharmacol. 1988 Jan;93(1):93-100. PubMed PMID: 3349236; PubMed Central PMCID: PMC1853787.

7: Posner J, Dean K, Jeal S, Moody SG, Peck AW, Rutter G, Telekes A. A preliminary study of the pharmacodynamics and pharmacokinetics of a novel enkephalin analogue [Tyr-D.Arg-Gly-Phe (4NO2).Pro.NH2 (BW443C)] in healthy volunteers. Eur J Clin Pharmacol. 1988;34(1):67-71. PubMed PMID: 3360050.

8: Esplugues JV, Barrachina MD, Esplugues J. Modulation by peripheral opioids of basal and distension-stimulated gastric acid secretion in the rat. Br J Pharmacol. 1992 May;106(1):33-8. PubMed PMID: 1504729; PubMed Central PMCID: PMC1907452.

9: Follenfant RL, Hardy GW, Lowe LA, Schneider C, Smith TW. Antinociceptive effects of the novel opioid peptide BW443C compared with classical opiates; peripheral versus central actions. Br J Pharmacol. 1988 Jan;93(1):85-92. PubMed PMID: 3349235; PubMed Central PMCID: PMC1853761.

10: Shankley CE, Anderson CW, Adcock JJ. Effect of BW443C81, a novel opioid, on non-cholinergic bronchoconstrictor responses and neurogenic plasma extravasation in the guinea pig. Agents Actions. 1992 May;36(1-2):22-8. PubMed PMID: 1414685.

11: Buchan P, Adcock JJ. Capsaicin-induced bronchoconstriction in the guinea-pig: contribution of vagal cholinergic reflexes, local axon reflexes and their modulation by BW443C81. Br J Pharmacol. 1992 Feb;105(2):448-52. PubMed PMID: 1559133; PubMed Central PMCID: PMC1908653.